Article

Allergy-related outcomes in relation to serum IgE: Results from the National Health and Nutrition Examination Survey 2005-2006

National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.
The Journal of allergy and clinical immunology (Impact Factor: 11.48). 02/2011; 127(5):1226-35.e7. DOI: 10.1016/j.jaci.2010.12.1106
Source: PubMed

ABSTRACT

The National Health and Nutrition Examination Survey (NHANES) 2005-2006 was the first population-based study to investigate levels of serum total and allergen-specific IgE in the general US population.
We estimated the prevalence of allergy-related outcomes and examined relationships between serum IgE levels and these outcomes in a representative sample of the US population.
Data for this cross-sectional analysis were obtained from NHANES 2005-2006. Study subjects aged 6 years and older (n = 8086) had blood taken for measurement of total IgE and 19 specific IgE levels against common aeroallergens, including Alternaria alternata, Aspergillus fumigatus, Bermuda grass, birch, oak, ragweed, Russian thistle, rye grass, cat dander, cockroach, dog dander, dust mite (Dermatophagoides farinae and Dermatophagoides pteronyssinus), mouse and rat urine proteins, and selected foods (egg white, cow's milk, peanut, and shrimp). Serum samples were analyzed for total and allergen-specific IgE by using the Pharmacia CAP System. Information on allergy-related outcomes and demographics was collected by questionnaire.
In NHANES 2005-2006, 6.6% reported current hay fever, and 23.5% had current allergies. Allergy-related outcomes increased with increasing total IgE levels (adjusted odds ratios for a 10-fold increase in total IgE level of 1.86 [95% CI, 1.44-2.41] for hay fever and 1.64 [95% CI, 1.41-1.91] for allergies). Increased levels of plant-, pet-, and mold-specific IgE contributed independently to allergy-related symptoms. The greatest increase in odds was observed for hay fever and plant-specific IgE (adjusted odds ratio, 4.75; 95% CI, 3.83-5.88).
In the US population self-reported allergy symptoms are most consistently associated with increased levels of plant-, pet-, and mold-specific IgE.

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Available from: Peter J Gergen, Mar 27, 2014
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    • "Sensitization was defined as detectable specific IgE (!0.35 kU/L). We investigated five allergic sensitization outcome variables [36]. These included: 1) any of the IgE antibodies; 2) outdoor allergen-specific IgEs (A. alternata, A. fumigatus, Bermuda grass, birch, oak, ragweed, Russian thistle, rye grass); 3) indoor allergen-specific IgEs [cat dander, cockroach, dog dander, dust mite (D. farinae and D. pteronyssinus), mouse proteins, rat urine proteins]; 4) inhalant (indoor or outdoor allergen-specific IgEs); and 5) food allergen-specific IgEs (egg white, cow's milk, peanut, shrimp). "
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    • "Exposure to high levels of Alternaria spores in the US Midwest during the spring and summer months is a risk factor for asthma attacks and has been associated with respiratory arrest among children and young adults (1) . Sensitization and exposure to Alternaria species was also associated with asthma in the Inner City Asthma Studies and the most recent National Health and Nutrition Examination Survey (2) (3) (4) (5) (6) . "
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