Article

Sequencing for the cream of the crop

Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.
Nature Biotechnology (Impact Factor: 41.51). 02/2011; 29(2):138-9. DOI: 10.1038/nbt.1756
Source: PubMed

ABSTRACT

Sequencing technologies are poised to transform conventional strategies for crop improvement.

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    • "This might be particularly true for polyploid crops in which assignment of genic SNPs to specific homologous loci can often be more reliable using haplotype-oriented sequencing data than on array platforms. Furthermore, because they can theoretically access novel allelic variants in genetically diverse association panels, NGS-based genotyping methods (see Davey et al. 2011 for a comprehensive review) have a potential advantage over array-based SNP screening methods that only survey known alleles in a given panel of SNPs (Chia and Ware 2011). Use of SNPs discovered by genomic resequencing for GWAS was shown by Huang et al. (2010) to be highly effective for uncovering genes involved in important agronomic traits in rice. "
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