Dyslipidemia and lipid management in HIV-infected patients

Department of Medicine, Harvard Medical School, Program in Nutritional Metabolism, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
Current opinion in endocrinology, diabetes, and obesity (Impact Factor: 3.37). 02/2011; 18(2):144-7. DOI: 10.1097/MED.0b013e328344556e
Source: PubMed


Dyslipidemia is highly prevalent among patients living with chronic HIV infection and may confer increased risk of cardiovascular disease in this patient population. This review summarizes recent data investigating lipid abnormalities and its management in HIV-infected patients.
Studies in the last year have evaluated the effects of various lipid-lowering therapies not previously investigated in the HIV patient population. Rosuvastatin is a potent statin that appears to be well tolerated and effective in HIV-infected patients with hypercholesterolemia.
Dyslipidemia is common in HIV-infected individuals. Medical therapy of lipid disorders needs to take potential drug-drug interactions of lipid-lowering medications and antiretroviral agents into consideration.

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    • "Unfortunately, despite a relatively high number of HIV-infected patients receiving statins for the control of hyperlipidemia due to cART [81,82], there is a lack of reported data on the incidence of HAND and neurological impairment in the statin-treated HIV-infected population, as well as the effect of statins on HAND. The potential utility of these compounds requires further investigation in the context of HIV. "
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