Cell Migration: GSK3 beta Steers the Cytoskeleton's Tip

Program in Epithelial Biology, Stanford University, School of Medicine, CA 94305, USA.
Cell (Impact Factor: 32.24). 02/2011; 144(3):319-21. DOI: 10.1016/j.cell.2011.01.023
Source: PubMed


Directed cell migration polarizes the cytoskeleton, allowing the cell to move toward migratory cues. In this issue, Wu et al. (2011) demonstrate that the glycogen synthase kinase 3β (GSK3β) controls microtubule architecture and polarized movement of skin stem cells during wound healing in mammals by regulating the microtubule crosslinking protein ACF7.

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