Gastric cancer in young people.

Canadian family physician Médecin de famille canadien (Impact Factor: 1.34). 06/1985; 31:1335-8.
Source: PubMed


Gastric carcinoma occurs in young people as well as old; incidence in various studies of patients from different age groups suggests that incidence varies more according to location than to age-incidence in young people can be up to 3% in some areas. Diaries of two women who were under age 35 at the time of diagnosis of gastric cancer are presented. Because the disease is relatively rare in the young and the symptoms are very similar to benign ulcers, the diagnosis is often made late. Radiological investigation, signs, symptoms and family history must be carefully scrutinized; if medical ulcer therapy has no effect, every attempt must be made to reach a further diagnosis as soon as possible.

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    • "Additionally, the role of environmental carcinogenic factors in carcinogenesis is presumably less prominent in young people than is the genetic one; thus, hereditary gastric cancer and early-onset gastric cancer can aid in the study of carcinogenesis at this age. In our series, 33% had familial oncological histories without formation of hereditary or familial cancer, suggesting a genetic transmission component because the most frequently found types of cancer were cervical uterine cancer and leukemia.11,12 Gastrointestinal adenocarcinomas of the esophagus, stomach, and colon exhibit distinct patterns of genomic instability and oncogenesis. "
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    ABSTRACT: Background: Gastric cancer is an aggressive disease with nonspecific early symptoms. Its incidence and prognosis in young patients has shown considerable variability. Purpose of the study: Our objective was to retrospectively study patients from our institution aged ,30 years with gastric carcinoma. The study was undertaken to describe the experience of gastric cancer in this population, and to demonstrate its specific clinical and pathological characteristics. Materials and methods: We reviewed the cases of histologically confirmed gastric cancer between 1985 and 2006 at the Instituto Nacional de Cancerología of Mexico (INCan); emphasis in our review was placed on clinical presentation, diagnostic and therapeutic intervention, pathology, and the results. Results: Thirty cases of gastric carcinoma were reviewed. The patients’ median age was 27 years (range, 18–30 years) and the male:female ratio was 1:1. Conclusion: Gastric cancer exhibits different behavior in patients aged ,30 years, but delay in diagnosis and the tumor’s behavior appear to be the most important factors in prognosis of the disease.
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    ABSTRACT: To determine the factors affecting survival, following resection of large bowel for colorectal carcinoma. From the cancer database of a single referral institution, a total of 1090 patients who had undergone colorectal resection between 1999 and 2002 were identified. Cases with recurrent colorectal cancer or previous history of neoadjuvant chemotherapy were excluded. Survival curves were plotted using the Kaplan-Meier method. Univariate analysis of factors thought to influence survival was then made using Logrank test. Criteria studied consisted of age, sex, TNM stage, T-status, nodal status, distant metastasis, histological grade, lymphatic and vascular invasion, tumour location, preoperative carcinoembryonic antigen (CEA) level and liver function tests. Multivariate analysis was conducted using Cox regression analysis. The mean survival time for all patients was 42.8 (SEM = 2.8) months. The overall 1-, 3- and 5-year survival rates were 72%, 54% and 47%, respectively. In univariate analysis, patients' age (P < 0.0001), TNM stage (P < 0.0001), T-status (P = 0.015), nodal status (P = 0.016), distant metastasis (P < 0.0001), grade (P = 0.005), lymphatic and vascular invasion (P < 0.0001) and presurgery CEA level > 5 ng/ml (P = 0.021) were found to be predictors that could affect survival. In Cox regression analysis, age (P < 0.0001), TNM stage (P = 0.001) and grade (P = 0.008) were determined as independent prognostic factors of survival. Age, TNM stage, T-status, nodal status, distant metastasis, grade, lymphatic and vascular invasion and presurgery CEA level can predict the postsurgical survival rate in patients with colorectal cancer.
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