Vaccine-related varicella-zoster rash in a hospitalized immunocompetent patient

Department of Infection Prevention and Control, New York Presbyterian Hospital, NY 10032, USA.
American journal of infection control (Impact Factor: 2.21). 04/2011; 39(3):247-9. DOI: 10.1016/j.ajic.2010.06.027
Source: PubMed


An immunocompetent health care worker with no known history of varicella-zoster virus (VZV) disease was exposed to a patient with herpes zoster and was immunized 2 days later. Twenty-seven days after receiving the varicella vaccine, while hospitalized, she developed a disseminated rash. This exposure and subsequent development of symptoms posed infection control challenges. A polymerase chain reaction analysis of her vesicular fluid was positive for vaccine-type VZV, and a blood specimen collected before vaccination demonstrated a positive VZV titer by the fluorescent antibody to membrane antigen test. To the best of our knowledge, there have been no previous reports of an immunocompetent seropositive person developing vaccine-type VZV after receiving the vaccine.

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    • "An immunocompetent HCW with no known history of varicella-zoster virus disease was exposed to a patient with herpes zoster and was immunized 2 days later. Twenty-seven days after receiving the varicella vaccine, while hospitalized, she developed a disseminated rash [28]. Occupationally acquired infection with methicillin-resistant Staphylococcus aureus (MRSA) is an issue of increasing concern. "
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