50 Years Later: Remembering the Paper

Stanford Institute of Stem Cell Biology and Regenerative Medicine, Stanford, CA, USA.
Radiation Research (Impact Factor: 2.91). 02/2011; 175(2):143-4. DOI: 10.2307/41061202
Source: PubMed
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    • "Till and McCulloch published a seminal paper, which was published in its original form again this year, providing a quantitative method for analyzing hematopoietic cells capable of continued proliferation in vivo and providing a singularly important observation that single cells could give rise to all hematopoietic lineages in vivo (Till and McCulloch, 1961, 2011; Weissman, 2011). Supralethally irradiated mice were injected with nucleated bone marrow cells and the spleen colony-forming units quantified. "
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    ABSTRACT: This is a chronicle of concepts in the field of epidermal stem cell biology and a historic look at their development over time. The past 25 years have seen the evolution of epidermal stem cell science, from first fundamental studies to a sophisticated science. The study of epithelial stem cell biology was aided by the ability to visualize the distribution of stem cells and their progeny through lineage analysis studies. The excellent progress we have made in understanding epidermal stem cell biology is discussed in this article. The challenges we still face in understanding epidermal stem cells include defining molecular markers for stem and progenitor sub-populations, determining the locations and contributions of the different stem cell niches, and mapping regulatory pathways of epidermal stem cell proliferation and differentiation. However, our rapidly evolving understanding of epidermal stem cells has many potential uses that promise to translate into improved patient therapy.
    Full-text · Article · Dec 2011 · Journal of Investigative Dermatology

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