Association between Depression and C-Reactive Protein

Division of Preventive and Behavioral Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, 01655, USA.
Cardiology Research and Practice 12/2010; 2011(4, supplement s):286509. DOI: 10.4061/2011/286509
Source: PubMed


. Depression has been associated with increased cardiovascular disease risk, and a depression-related elevation of high sensitivity C-reactive protein (hs-CRP) has been proposed as a possible mechanism. The objective of this paper is to examine association between depression and high sensitivity C-reactive protein (hs-CRP).
. Subjects consisted of 508 healthy adults (mean age 48.5 years; 49% women, 88% white) residing in central Massachusetts. Data were collected at baseline and at quarterly intervals over a one-year period per individual. Multivariable linear mixed models were used to assess the association for the entire sample and by gender.
. The mean Beck Depression Inventory score was 5.8 (standard deviation (SD) 5.4; median 4.3), and average serum hs-CRP was 1.8 mg/L (SD 1.7; median 1.2). Results from the multivariable linear mixed models show that individuals with higher depression scores have higher levels of hs-CRP. Analyses by gender show persistence of an independent association among women, but not among men. Body mass index (BMI = weight(kg)/height(m)
) appears to be a partial mediator of this relationship.
. Depression score was correlated to hs-CRP levels in women. Further studies are required to elucidate the biological mechanisms underlying these associations and their implications.

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    • "Our result showed that elevated CRP level was associated with lowered HDL and overweight/obesity. Other studies have shown that CRP is associated with components of MTB, like abdominal obesity (17,18). Adipose tissue secretes a number of proinflammatory cytokines including interleukin 6 (IL-6), which regulates hepatic production of CRP (19). "
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