• Good review article of current theories on cancer and immunity.
• Underscores the importance of the functional competence of the cells involved,
all of which are impacted by either immune aging and/or severe depletion.
Annu Rev Immunol. 2011 Apr 23;29:235-71.
Natural innate and adaptive immunity to cancer.
Vesely MD, Kershaw MH, Schreiber RD, Smyth MJ.
Department of Pathology and Immunology, Washington University School of Medicine, Missouri, USA.
Abstract - The immune system can identify and destroy nascent tumor cells in a process
termed cancer immunosurveillance, which functions as an important defense against cancer.
Recently, data obtained from numerous investigations in mouse models of cancer and in
humans with cancer offer compelling evidence that particular innate and adaptive immune
cell types, effector molecules, and pathways can sometimes collectively function as extrinsic
tumor-suppressor mechanisms. However, the immune system can also promote tumor
progression. Together, the dual host-protective and tumor-promoting actions of immunity
are referred to as cancer immunoediting. In this review, we discuss the current experimental
and human clinical data supporting a cancer immunoediting process that provide the
fundamental basis for further study of immunity to cancer and for the rational design of
immunotherapies against cancer.