X-Ray Repair Cross-Complementing Group 1 (XRCC1) Genetic Polymorphisms and Gastric Cancer Risk: A HuGE Review and Meta-Analysis

Department of Gastroenterology, Renji Hospital, Shanghai Institute of Gastrointestinal Diseases, School of Medicine, Shanghai Jiaotong University, People’s Republic of China.
American journal of epidemiology (Impact Factor: 5.23). 02/2011; 173(4):363-75. DOI: 10.1093/aje/kwq378
Source: PubMed


The authors performed a systematic review and meta-analysis of associations of the x-ray repair cross-complementing 1 gene (XRCC1) single nucleotide polymorphisms (SNPs) Arg194Trp, Arg280His, and Arg399Gln with gastric cancer risk, based on eligible studies retrieved from electronic databases for the period January 2000-December 2009. Ultimately, 12, 6, and 3 studies were found to be eligible for meta-analyses of Arg399Gln, Arg194Trp, and Arg280His, respectively. Regrouping was adopted in accordance with the most probably appropriate genetic models. Potential sources of heterogeneity were sought out. For overall gastric cancer, the pooled odds ratios for Arg399Gln, Arg194Trp, and Arg280His were 1.04 (95% confidence interval (CI): 0.90, 1.20; P = 0.572), 0.83 (95% CI: 0.68, 1.01; P = 0.059), and 1.18 (95% CI: 0.92, 1.50; P = 0.194), respectively. After stratification of the Arg399Gln SNP data by anatomic type (cardia vs. noncardia), the pooled odds ratio was 1.07 (95% CI: 0.84, 1.37; P = 0.568). The authors conclude that the 3 SNPs evaluated are not associated with risk of gastric cancer. The Arg399Gln SNP is not associated with the cardia type of gastric cancer. Evidently, the heterogeneity regarding the Arg399Gln SNP across studies is not explained by ethnicity, genotyping technique, sample size, or date of publication.

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    • "Other genes found in our study have also been reported relating with gastric cancer. Specific SNPs (Single Nucleotide Polymorphism) in XRCC1 (X-ray repair cross-complementing 1) (see row 7 of Table 2) are highly associated with gastric cancer [95]. DNMT1 (DNA methyltransferase 1) (see row 8 of Table 2), which is overexpressed in gastric cancer, is associated with increased risks of gastric atrophy with its abnormal polymorphisms [96]. "
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    • "X-ray repair cross-complementing group 1 (XRCC1) is involved in base excision repair protein that located on chromosome 19q13.2–13.3 with a length of 33 kb [1–4]. The polymorphisms of XRCC1 gene have been identified as three categories of codons 194(Arg to Trp), 280(Arg to His), and 399 (Arg toGln) [5, 6]. "
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