Association between Physical Activity and Kidney Function: National Health and Nutrition Examination Survey

University of Pittsburgh, Department of Epidemiology, Pittsburgh, PA, USA.
Medicine and science in sports and exercise (Impact Factor: 3.98). 12/2010; 43(8):1457-64. DOI: 10.1249/MSS.0b013e31820c0130
Source: PubMed


Chronic kidney disease is a condition characterized by the deterioration of the kidney's ability to remove waste products from the body. Although treatments to slow the progression of the disease are available, chronic kidney disease may eventually lead to a complete loss of kidney function. Previous studies have shown that physical activities of moderate intensity may have renal benefits. Few studies have examined the effects of total movement on kidney function. The purpose of this study was to determine the association between time spent at all levels of physical activity intensity and sedentary behavior and kidney function.
Data were obtained from the 2003-2004 and 2005-2006 National Health and Nutrition Examination Survey, a cross-sectional study of a complex, multistage probability sample of the US population. Physical activity was assessed using an accelerometer and questionnaire. Glomerular filtration rate (eGFR) was estimated using the Modification of Diet in Renal Disease study formula. To assess linear associations between levels of physical activity and sedentary behavior with log-transformed estimated GFR (eGFR), linear regression was used.
In general, physical activity (light and total) was related to log eGFR in females and males. For females, the association between light and total physical activity with log eGFR was consistent regardless of diabetes status. For males, the association between light and total physical activity and log eGFR was only significant in males without diabetes.
When examining the association between physical activity, measured objectively with an accelerometer, and kidney function, total and light physical activities were found to be positively associated with kidney function.

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    • "Keywords: quality of life; social psychology; health behaviors; judgment A large consensus exists about health and psychological benefits of physical activity among the general population and in several medical conditions (Haskell et al., 2007; Hawkins et al., 2011). Until the mid-1990s, no studies existed to show whether health benefits of sport activity are achieved in organ transplant recipients. "
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    • "A recent Cochrane review has highlighted the potential positive effects of regular leisure exercise on advanced CKD mainly through the improvement of cardiovascular risk (diabetes, high blood pressure) [11] [12] [13] [14] and aerobic capacity [11]. However, the effect of physical activity on early stages of CKD is not well-established [12], and few studies have focused specifically on it [15] [16] [17]. The eGFR is one of the essential determinants that characterize CKD. "
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    • "This relationship lost statistical significance after adjustment for BMI, cholesterol, CRP and mean arterial blood pressure. Increased physical activity may reduce the progression of chronic kidney disease by decreasing oxidative stress and inflammation and reducing blood pressure besides the positive effect of weight loss [28]. Conceivably decreased physical activity, in our study bed rest, has the opposite effect with an increase in oxidative stress and inflammation. "
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