Association between Physical Activity and Kidney Function: National Health and Nutrition Examination Survey

ArticleinMedicine and science in sports and exercise 43(8):1457-64 · December 2010with17 Reads
DOI: 10.1249/MSS.0b013e31820c0130 · Source: PubMed
Abstract
Chronic kidney disease is a condition characterized by the deterioration of the kidney's ability to remove waste products from the body. Although treatments to slow the progression of the disease are available, chronic kidney disease may eventually lead to a complete loss of kidney function. Previous studies have shown that physical activities of moderate intensity may have renal benefits. Few studies have examined the effects of total movement on kidney function. The purpose of this study was to determine the association between time spent at all levels of physical activity intensity and sedentary behavior and kidney function. Data were obtained from the 2003-2004 and 2005-2006 National Health and Nutrition Examination Survey, a cross-sectional study of a complex, multistage probability sample of the US population. Physical activity was assessed using an accelerometer and questionnaire. Glomerular filtration rate (eGFR) was estimated using the Modification of Diet in Renal Disease study formula. To assess linear associations between levels of physical activity and sedentary behavior with log-transformed estimated GFR (eGFR), linear regression was used. In general, physical activity (light and total) was related to log eGFR in females and males. For females, the association between light and total physical activity with log eGFR was consistent regardless of diabetes status. For males, the association between light and total physical activity and log eGFR was only significant in males without diabetes. When examining the association between physical activity, measured objectively with an accelerometer, and kidney function, total and light physical activities were found to be positively associated with kidney function.
    • "Keywords: quality of life; social psychology; health behaviors; judgment A large consensus exists about health and psychological benefits of physical activity among the general population and in several medical conditions (Haskell et al., 2007; Hawkins et al., 2011). Until the mid-1990s, no studies existed to show whether health benefits of sport activity are achieved in organ transplant recipients. "
    [Show abstract] [Hide abstract] ABSTRACT: The aim of the study was to investigate the effects of sport activity on health-related quality of life (HRQoL) of solid organ transplant recipients participating in sports competitions. A group of 168 sportive transplanted patients (STP), a group of 97 nonsportive transplanted patients (NSTP), and a group of 152 sportive healthy controls (SHC) were compared on the eight scales of the SF-36 questionnaire. STP and NSTP reported significantly lower scores than SHC on the physical functioning scale. STP did not differ from SHC in the Role-Physical, General Health, and Vitality scales, while NSTP reported significantly lower scores. STP obtained higher scores than NSTP and SHC on Mental Health. Among STP, the effect of quantity of sport activity was significant on General Health and Role Emotional, with more sport activity associated with higher HRQoL. Organ failure and post-transplant therapies may have negative consequences on HRQoL. Sports activities and participation in sports competitions can reduce this impact, improving general and psychological functioning of solid organ transplant recipients.
    Article · Dec 2014
    • "Thus, longitudinal studies and randomized trials assessing the role of physical activity in modifying the early development of CKD are required to confirm these results. Few studies have focused on the impact of physical activity on early stages of eGFR and among the three recent cross-sectional studies, two evaluated eGFR according to the MDRD formula [17,30] and one used the Cockroft–Gault equation [15]. Recently, it has emerged that the more accurate and accessible equation for estimating GFR is that based on serum creatinine by CKD-EPI equation [21,22], as used here. "
    [Show abstract] [Hide abstract] ABSTRACT: Chronic kidney disease is now regarded as a risk factor for cardiovascular disease. The impact of occupational or non-occupational physical activity (PA) on moderate decreases of renal function is uncertain. We aimed to identify the potential association of PA (occupational and leisure-time) on early decline of estimated glomerular filtration rate (eGFR) and to determine the potential mediating effect of PA on the relationship between eGFR and heart disease. From the PRIME study analyses were conducted in 1058 employed men. Energy expended during leisure, work and commuting was calculated. Linear regression analyses were used to determine the link between types of PA and moderate decrements of eGFR determined with the KDIGO guideline at the baseline assessment. Cox proportional hazards analyses were used to explore the potential effect of PA on the relationship between eGFR and heart disease, ascertained during follow-up over 10years. For these employed men, and after adjustment for known confounders of GFR change, more time spent sitting at work was associated with increased risk of moderate decline in kidney function, while carrying objects or being active at work was associated with decreased risk. In contrast, no significant link with leisure PA was apparent. No potential mediating effect of occupational PA was found for the relationship between eGFR and coronary heart disease. Occupational PA (potential modifiable factors) could provide a dual role on early impairment of renal function, without influence on the relationship between early decrease of e-GFR and CHD risk. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.
    Full-text · Article · Sep 2014
    • "In the present study daily physical activity was positively correlated with creatinine clearance. Indeed, previous studies have shown that habitual physical activity was positively associated with renal function313233. Why decrease in creatinine clearance was associated with decreased physical activity? Currently the exact mechanisms are unknown but speculations can be made. "
    [Show abstract] [Hide abstract] ABSTRACT: The present study was carried out to investigate independent relationship between daily physical activity, microalbuminuria, and kidney function. The demographic characteristics and laboratory parameters were recorded for all patients. The determination of daily activities was carried out by Nottingham Extended Activities of Daily Living Scale (NEADLS) which was performed for each patient in an interview. Totally 139 patients were enrolled. In the whole group NEADLS score was correlated with age (rho: -0.759, P < 0.0001), clinical systolic blood pressure (rho: -0.212, P: 0.018), blood urea nitrogen (rho: -0.516, P < 0.0001), creatinine (rho: -0.501, P < 0.0001), uric acid (rho: -0.308, P < 0.0001), albumin (rho: 0.382, P < 0.0001), total cholesterol (rho: -0.194, P: 0.022), LDL-cholesterol (rho: -0.230, P: 0.008), hemoglobin (rho: 0.256, P: 0.002), creatinine clearance (rho: 0.565, P < 0.0001), 24-hour urinary protein excretion (rho: -0.324, P < 0.0001), and 24-hour urinary albumin excretion (UAE) (rho: -0.483, P < 0.0001). The multivariate linear regression of independent factors corelated with logarithmically converted NEADLS score (as a dependent variable) has shown that age (P < 0.0001), presence of coronary artery disease (P: 0.011), hemoglobin (P: 0.020), 24-hour creatinine clearance (P: 0.004), and 24-hour urinary albumin excretion (P < 0.0001) were independently corelated with NEADLS score. In conclusion, both UAE and kidney function were independently associated with daily physical activity.
    Full-text · Article · Dec 2013
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