Article

Association of Subcutaneous and Visceral Adiposity With Albuminuria: The Framingham Heart Study

National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, USA.
Obesity (Impact Factor: 3.73). 12/2010; 19(6):1284-9. DOI: 10.1038/oby.2010.308
Source: PubMed

ABSTRACT

Microalbuminuria is a common condition associated with increased incidence of cardiovascular events and mortality. Abdominal obesity is associated with microalbuminuria, but studies linking visceral adipose tissue (VAT) and microalbuminuria are limited. Our objective was to determine the associations of albuminuria with VAT and subcutaneous adipose tissue (SAT). We performed a cross-sectional study in the Framingham Multi-Detector Computed Tomography (MDCT) cohort (n = 3099, 48.2% women, mean age 53 years). VAT and SAT volumes were measured using computed tomography. Urinary albumin-to-creatinine ratio (UACR) was calculated from spot urine samples. Microalbuminuria was defined as a UACR >25 mg/g in women or >17 mg/g in men. Overall, 7.9% (n = 244) of the sample had microalbuminuria. Among men, VAT (odds ratio (OR) 1.48 per s.d., P < 0.0001) and SAT (OR 1.37 per s.d., P = 0.0002) were associated with microalbuminuria in minimally adjusted models, which remained significant after multivariable adjustment (VAT OR 1.34 per s.d., P = 0.001; SAT OR 1.28 per s.d., P = 0.005). Additionally, when considered jointly, VAT (P = 0.002) but not SAT (P = 0.2) was associated with microalbuminuria. In women, VAT was associated with microalbuminuria after minimal adjustment (OR 1.28, P = 0.01), but not after multivariable adjustment (OR 1.03, P = 0.8). In multivariable models in women, SAT was associated with a decreased odds of having microalbuminuria (OR 0.75 per s.d., P = 0.03). In conclusion, VAT is associated with microalbuminuria in men but not women. Albuminuria may be a manifestation of visceral adiposity.

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    • "Visceral adiposity has been reported to be associated with incident hypertension[37,38]and albuminuria[39,40]. More recently, we found that high visceral fat with low subcutaneous fat accumulation is an important determinant of carotid atherosclerosis and high subcutaneous fat could be protective against atherosclerosis in patients with type 2 diabetes[41], and others reported that subcutaneous fat thickness assessed by ultrasound is inversely associated with carotid atherosclerosis in diabetic patients, particularly in men[42]. "

    Preview · Article · Dec 2016 · Cardiovascular Diabetology
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    • "Data from the MONICA Augsburg survey 1994/95 [23] showed that microalbuminuric subjects had a higher WC, WHR and prevalence of elevated central adiposity and obesity than subjects without microalbuminuria. Another study [28] using measurements of visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) revealed that VAT was associated with microalbuminuria in men but not in women and showed that microalbuminuria may represent a manifestation of visceral adiposity. However, our observation of an association between a low WC and risk of microalbuminuria argues against that assumption. "
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