ChemInform Abstract: Transition Metal Mediated Construction of Pyrrole Ring on 2,3-Dihydroquinolin-4(1H)-one: Synthesis and Pharmacological Evaluation of Novel Tricyclic Heteroarenes.

Custom Pharmaceutical Services, Dr Reddy's Laboratories Limited, Bollaram Road Miyapur, Hyderabad, 500 049, India.
Organic & Biomolecular Chemistry (Impact Factor: 3.56). 02/2011; 9(4):1004-7. DOI: 10.1039/c0ob00771d
Source: PubMed


A facile two-step method for the construction of fused pyrrole ring leading to 5-substituted 2,3-dihydro-1H-pyrrolo[3,2,1-ij]quinolin-1-ones via C-C followed by intramolecular C-N bond forming reaction is described. In vitro pharmacological evaluation and molecular modelling studies of some of the compounds synthesized are presented.

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