Perioperative antibiotic prophylaxis in orthognathic surgery: A systematic review and meta-analysis of clinical trials
The aim of this study was to investigate whether the use of antibiotic prophylaxis in orthognathic surgery can effectively reduce the postoperative infection rate.
Electronic databases were searched and reference lists checked. Full articles meeting the inclusion criteria were retrieved. Study details and outcome data of these reports were statistically analyzed. There was no language limitation.
Five randomized clinical trials were included in the final review process: 4 articles compared the period of prophylactic antibiotic usage, and 1 compared the infection prevention effect of different types of antibiotics with placebo. Although a significantly higher infection rate was found in the placebo group, no significant difference could be found related to infection prevention between short- and long-term antibiotic regimen.
Prophylactic antibiotic regimen is considered to be useful for infection prevention in orthognathic surgery. A single-dose regimen is recommended; application for extended postoperative period is not advocated.
Available from: PubMed Central
- "Five randomized clinical trials were included in the final review process: four of them compared the period of the prophylactic antibiotic usage, and the other one compared the infection prevention performance of different types of antibiotics with that of the placebo. Although a significantly higher infection rate was found in the placebo group, no significant differences could be found related to the infection prevention between the short-term and long-term antibiotic regimen.17 "
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ABSTRACT: Objective:To clarify the use of antibiotics in our hospital and to guide the prophylactic use in future hepatobiliary surgical procedures.
Methodology: A retrospective review of patients who underwent hepatobiliary surgery from January 2011 to June 2011 was included. Data were collected, and surgical site infection (SSI) was defined by the criteria of Center for Disease Control and Prevention. Patients were prescribed antibiotics for the clinical diagnosis of hepatobiliary system diseases.
Results: 1564 patients were identified, in which 784 patients (50.13%) did not receive preoperative antibiotic prophylaxis. Of these 355 patients with 784 surgical sites received either preoperative or both preoperative and postoperative antibiotic prophylaxis. The SSI rate of the patients who received prophylaxis alone (2.56%, 20 of 780 sites) was not statistically higher than that of the patients who have not received prophylaxis (2.68%, 21 of 784 sites), and the two groups were not statistically correlated (P=0.77).
Conclusion: The number of the patients who developed SSI was relatively low, and no reduction in the SSI rate was observed among the patients who have received antibiotic prophylaxis.
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