Article

The MCCB impairment profile for schizophrenia outpatients: Results from the MATRICS psychometric and standardization study

UCLA Semel Institute for Neuroscience & Human Behavior, David Geffen School of Medicine, Los Angeles, CA 90073, United States.
Schizophrenia Research (Impact Factor: 3.92). 03/2011; 126(1-3):124-31. DOI: 10.1016/j.schres.2010.11.008
Source: PubMed

ABSTRACT

The MATRICS Psychometric and Standardization Study was conducted as a final stage in the development of the MATRICS Consensus Cognitive Battery (MCCB). The study included 176 persons with schizophrenia or schizoaffective disorder and 300 community residents. Data were analyzed to examine the cognitive profile of clinically stable schizophrenia patients on the MCCB. Secondarily, the data were analyzed to identify which combination of cognitive domains and corresponding cut-off scores best discriminated patients from community residents, and patients competitively employed vs. those not. Raw scores on the ten MCCB tests were entered into the MCCB scoring program which provided age- and gender-corrected T-scores on seven cognitive domains. To test for between-group differences, we conducted a 2 (group)×7 (cognitive domain) MANOVA with follow-up independent t-tests on the individual domains. Classification and regression trees (CART) were used for the discrimination analyses. Examination of patient T-scores across the seven cognitive domains revealed a relatively compact profile with T-scores ranging from 33.4 for speed of processing to 39.3 for reasoning and problem-solving. Speed of processing and social cognition best distinguished individuals with schizophrenia from community residents; speed of processing along with visual learning and attention/vigilance optimally distinguished patients competitively employed from those who were not. The cognitive profile findings provide a standard to which future studies can compare results from other schizophrenia samples and related disorders; the classification results point to specific areas and levels of cognitive impairment that may advance work rehabilitation efforts.

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    • "Since the launch of the MCCB as the standard neurocognitive assessment battery for schizophrenia trials, it has been linked to occupational outcome in a few studies (August et al., 2012; Durand et al., 2015; Gould et al., 2015; Kern et al., 2011; Shamsi et al., 2011; Vargas et al., 2014). Specifically, the battery has proven sensitive in differentiating between employed and unemployed persons (August et al., 2012; Kern et al., 2011) as well as predictive of work and education (Shamsi et al., 2011). Although several studies have tied MCCB performance to occupational status, the issue concerning associations between the MCCB and occupational performance still needs elaboration. "
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