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Chamomile: A herbal medicine of the past with a bright future (Review)



Chamomile is one of the most ancient medicinal herbs known to mankind. It is a member of Asteraceae/Compositae family and represented by two common varieties viz. German Chamomile (Chamomilla recutita) and Roman Chamomile (Chamaemelum nobile). The dried flowers of chamomile contain many terpenoids and flavonoids contributing to its medicinal properties. Chamomile preparations are commonly used for many human ailments such as hay fever, inflammation, muscle spasms, menstrual disorders, insomnia, ulcers, wounds, gastrointestinal disorders, rheumatic pain, and hemorrhoids. Essential oils of chamomile are used extensively in cosmetics and aromatherapy. Many different preparations of chamomile have been developed, the most popular of which is in the form of herbal tea consumed more than one million cups per day. In this review we describe the use of chamomile in traditional medicine with regard to evaluating its curative and preventive properties, highlight recent findings for its development as a therapeutic agent promoting human health.
Chamomile: A herbal medicine of the past with bright future
Janmejai K Srivastava1,2,*, Eswar Shankar1,2, and Sanjay Gupta1,2,3
1Department of Urology & Nutrition, Case Western Reserve University, Cleveland, Ohio 44106
2Department of Urology & Nutrition, University Hospitals Case Medical Center, Cleveland, Ohio
3Department of Urology & Nutrition, Case Comprehensive Cancer Center, Cleveland, Ohio 44106
Chamomile is one of the most ancient medicinal herbs known to mankind. It is a member of
Asteraceae/Compositae family and represented by two common varieties viz. German Chamomile
(Chamomilla recutita) and Roman Chamomile (Chamaemelum nobile). The dried flowers of
chamomile contain many terpenoids and flavonoids contributing to its medicinal properties.
Chamomile preparations are commonly used for many human ailments such as hay fever,
inflammation, muscle spasms, menstrual disorders, insomnia, ulcers, wounds, gastrointestinal
disorders, rheumatic pain, and hemorrhoids. Essential oils of chamomile are used extensively in
cosmetics and aromatherapy. Many different preparations of chamomile have been developed, the
most popular of which is in the form of herbal tea consumed more than one million cups per day.
In this review we describe the use of chamomile in traditional medicine with regard to evaluating
its curative and preventive properties, highlight recent findings for its development as a
therapeutic agent promoting human health.
chamomile; dietary agents; flavonoids; polyphenols; human health
The interplay of plants and human health has been documented for thousands of years (1–3).
Herbs have been integral to both traditional and non-traditional forms of medicine dating
back at least 5000 years (2,4–6). The enduring popularity of herbal medicines may be
explained by the tendency of herbs to work slowly, usually with minimal toxic side effects.
One of the most common herbs used for medicinal purposes is chamomile whose
standardized tea and herbal extracts are prepared from dried flowers of Matricaria species.
Chamomile is one of the oldest, most widely used and well documented medicinal plants in
the world and has been recommended for a variety of healing applications (7). Chamomile is
a native of the old World and is a member of the daisy family (Asteraceae or Compositae).
The hollow, bright gold cones of the flowers are packed with disc or tubular florets and are
ringed with about fifteen white ray or ligulate florets, widely represented by two known
varieties viz. German chamomile (Matricaria chamomilla) and Roman chamomile
(Chamaemelum nobile) (8) . In this review we will discuss the use and possible merits of
Correspondence to: Sanjay Gupta, Ph.D., Department of Urology, Case Western Reserve University, 10900 Euclid Avenue,
Cleveland, Ohio 44106, Phone: (216) 368 6162; Fax: (216) 368 0213;
*Current address: Amity Institute of Biotechnology (Mango Orchard Campus), Amity University, Lucknow Campus, Viraj Khand
5, Gomti Nagar, Lucknow, India
NIH Public Access
Author Manuscript
Mol Med Report. Author manuscript; available in PMC 2011 February 1.
Published in final edited form as:
Mol Med Report
. 2010 November 1; 3(6): 895–901. doi:10.3892/mmr.2010.377.
NIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author Manuscript
chamomile, examining its historical use and recent scientific and clinical evaluations of its
potential use in the management of various human ailments.
Different classes of bioactive constituents are present in chamomile, which have been
isolated and used as medicinal preparations and cosmetics (9). The plant contains 0.24%–
1.9% volatile oil, composed of a variety of separate oils. When exposed to steam distillation,
the oil ranges in color from brilliant blue to deep green when fresh but turns to dark yellow
after storage. Despite fading, the oil does not lose its potency. Approximately 120 secondary
metabolites have been identified in chamomile, including 28 terpenoids and 36 flavonoids
(10,11). The principal components of the essential oil extracted from the German chamomile
flowers are the terpenoids α-bisabolol and its oxide azulenes including chamazulene and
acetylene derivatives. Chamazulene and bisabolol are very unstable and are best preserved
in an alcoholic tincture. The essential oil of Roman chamomile contains less chamazulene
and is mainly constituted from esters of angelic acid and tiglic acid. It also contains
farnesene and α-pinene. Roman chamomile contains up to 0.6% of sesquiterpene lactones of
the germacranolide type, mainly nobilin and 3-epinobilin. Both α-bisabolol, bisabolol oxides
A and B and chamazulene or azulenesse, farnesene and spiro-ether quiterpene lactones,
glycosides, hydroxycoumarins, flavanoids (apigenin, luteolin, patuletin, and quercetin),
coumarins (herniarin and umbelliferone), terpenoids, and mucilage are considered to be the
major bio-active ingredients (12,13). Other major constituents of the flowers include several
phenolic compounds, primarily the flavonoids apigenin, quercetin, patuletin as glucosides
and various acetylated derivatives. Among flavonoids, apigenin is the most promising
compound. It is present in very small quantities as free apigenin, but predominantly exists in
the form of various glycosides (14–18).
Chamomile is known to be used in various forms of its preparations. Dry powder of
chamomile flower is recommended and used by many people for traditionally established
health problems. Medicinal ingredients are normally extracted from the dry flowers of
chamomile by using water, ethanol or methanol as solvents and corresponding extracts are
known as aqueous, ethanolic (alcoholic) and/or methanolic extracts. Optimum chamomile
extracts contain about 50 percent alcohol. Normally standardized extracts contain 1.2% of
apigenin which is one of the most effective bioactive agents. Aqueous extracts, such as in
the form of tea, contain quite low concentrations of free apigenin but include high levels of
apigenin-7-O-glucoside. Oral infusion of chamomile is recommended by the German
Commission E (19,20).Chamomile tea is one of the world’s most popular herbal teas and
about a million cups are consumed every day. Tea bags of chamomile are also available in
the market, containing chamomile flower powder, either pure or blended with other popular
medicinal herbs. Chamomile tincture may also be prepared as one part chamomile flower in
four parts of water having 12% grain alcohol, which is used to correct summer diarrhea in
children and also used with purgatives to prevent cramping. Chamomile flowers are
extensively used alone, or combined with crushed poppy-heads, as a poultice or hot foment
for inflammatory pain or congestive neuralgia, and in cases of external swelling, such as
facial swelling associated with underlying infection or abscess. Chamomile whole plant is
used for making herb beers, and also for a lotion, for external application in toothache,
earache, neuralgia and in cases of external swelling (20). It is also known to be used as bath
additive, recommended for soothing ano-genital inflammation (21). The tea infusion is used
as a wash or gargle for inflammation of the mucous membranes of the mouth and throat
(22,23). Inhalation of the vaporized essential oils derived from chamomile flowers is
recommended to relieve anxiety, general depression. Chamomile oil is a popular ingredient
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of aromatherapy and hair care (24,25). Roman chamomile is widely used in cosmetic
preparations and in soothing and softening effect on the skin (26,27).
Traditionally, chamomile has been used for centuries as an anti-inflammatory, antioxidant,
mild astringent and healing medicine (28). As a traditional medicine, it is used to treat
wounds, ulcers, eczema, gout, skin irritations, bruises, burns, canker sores, neuralgia,
sciatica, rheumatic pain, hemorrhoids, mastitis and other ailments (29,30). Externally,
chamomile has been used to treat diaper rash, cracked nipples, chicken pox, ear and eye
infections, disorders of the eyes including blocked tear ducts, conjunctivitis, nasal
inflammation and poison ivy (31,32). Chamomile is widely used to treat inflammations of
the skin and mucous membranes, and for various bacterial infections of the skin, oral cavity
and gums, and respiratory tract. Chamomile in the form of an aqueous extract has been
frequently used as a mild sedative to calm nerves and reduce anxiety, to treat hysteria,
nightmares, insomnia and other sleep problems (33). Chamomile has been valued as a
digestive relaxant and has been used to treat various gastrointestinal disturbances including
flatulence, indigestion, diarrhea, anorexia, motion sickness, nausea, and vomiting (34,35).
Chamomile has also been used to treat colic, croup, and fevers in children (36). It has been
used as an emmenagogue and a uterine tonic in women. It is also effective in arthritis, back
pain, bedsores and stomach cramps.
5.1 Anti-inflammatory and antiphlogistic properties
The flowers of chamomile contain 1–2% volatile oils including alpha-bisabolol, alpha-
bisabolol oxides A & B, and matricin (usually converted to chamazulene and other
flavonoids which possess anti-inflammatory and antiphlogistic properties (12,19,35,36). A
study in human volunteers demonstrated that chamomile flavonoids and essential oils
penetrate below the skin surface into the deeper skin layers (37). This is important for their
use as topical antiphlogistic (anti-inflammatory) agents. One of chamomile’s anti-
inflammatory activities involve the inhibition of LPS-induced prostaglandin E(2) release and
attenuation of cyclooxygenase (COX-2) enzyme activity without affecting the constitutive
form, COX-1 (38).
5.2 Anticancer activity
Most evaluations of tumor growth inhibition by chamomile involve studies with apigenin
which is one of the bioactive constituents of chamomile. Studies on preclinical models of
skin, prostate, breast and ovarian cancer have shown promising growth inhibitory effects
(39–43). In a recently conducted study, chamomile extracts were shown to cause minimal
growth inhibitory effects on normal cells, but showed significant reductions in cell viability
in various human cancer cell lines. Chamomile exposure induced apoptosis in cancer cells
but not in normal cells at similar doses (18). The efficacy of the novel agent TBS-101, a
mixture of seven standardized botanical extracts including chamomile has been recently
tested. The results confirm it to have a good safety profile with significant anticancer
activities against androgen-refractory human prostrate cancer PC-3 cells, both in vitro and in
vivo situation (44).
5.3 Common cold
Common cold (acute viral nasopharyngitis) is the most common human disease. It is a mild
viral infectious disease of the upper respiratory system. Typically common cold is not life-
threatening, although its complications (such as pneumonia) can lead to death, if not
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properly treated. Studies indicate that inhaling steam with chamomile extract has been
helpful in common cold symptoms (45); however, further research is needed to confirm
these findings.
5.4 Cardiovascular conditions
It has been suggested that regular use of flavonoids consumed in food may reduce the risk of
death from coronary heart disease in elderly men (46). A study assessed the flavonoid intake
of 805 men aged 65–84 years who were followed up for 5 years. Flavonoid intake (analyzed
in tertiles) was significantly inversely associated with mortality from coronary heart disease
and showed an inverse relation with incidence of myocardial infarction. In another study
(47), on twelve patients with cardiac disease who underwent cardiac catheterization,
hemodynamic measurements obtained prior to and 30 minutes after the oral ingestion of
chamomile tea exhibited a small but significant increase in the mean brachial artery
pressure. No other significant hemodynamic changes were observed after chamomile
consumption. Ten of the twelve patients fell into a deep sleep shortly after drinking the
beverage. A large, well-designed randomized controlled trial is needed to assess the
potential value of chamomile in improving cardiac health.
5.5 Colic/Diarrhea conditions
An apple pectin-chamomile extract may help shorten the course of diarrhea in children as
well as relieve symptoms associated with the condition (47). Two clinical trials have
evaluated the efficacy of chamomile for the treatment of colic in children. Chamomile tea
was combined with other herbs (German chamomile, vervain, licorice, fennel, balm mint)
for administration. In a prospective, randomized, double-blind, placebo-controlled study, 68
healthy term infants who had colic (2 to 8 weeks old) received either herbal tea or placebo
(glucose, flavoring). Each infant was offered treatment with every bout of colic, up to 150
mL/dose, no more than three times a day. After 7 days of treatment, parents reported that the
tea eliminated the colic in 57% of the infants, whereas placebo was helpful in only 26%
(P<0.01). No adverse effects with regard to the number of nighttime awakenings were noted
in either group (48). Another study examined the effects of a chamomile extract and apple
pectin preparation in 79 children (age 0.5–5.5 y) with acute, non-complicated diarrhea who
received either the chamomile/pectin preparation (n = 39) or a placebo (n = 40) for 3 days.
Diarrhea ended sooner in children treated with chamomile and pectin (85%), than in the
placebo group (58%) (49). These results provide evidence that chamomile can be used
safely to treat infant colic disorders.
5.6 Eczema
Topical applications of chamomile have been shown to be moderately effective in the
treatment of atopic eczema (50). It was found to be about 60% as effective as 0.25%
hydrocortisone cream (51). Roman chamomile of the Manzana type (Kamillosan (R)) may
ease discomfort associated with eczema when applied as a cream containing chamomile
extract. The Manzana type of chamomile is rich in active ingredients and does not exhibit
chamomile-related allergenic potential. In a partially double-blind, randomized study carried
out as a half-side comparison, Kamillosan(R) cream was compared with 0.5%
hydrocortisone cream and a placebo consisting only of vehicle cream in patients suffering
from medium-degree atopic eczema (52). After 2 weeks of treatment, Kamillosan(R) cream
showed a slight superiority over 0.5% hydrocortisone and a marginal difference as compared
to placebo. Further research is needed to evaluate the usefulness of topical chamomile in
managing eczema.
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5.7 Gastrointestinal conditions
Chamomile is used traditionally for numerous gastrointestinal conditions, including
digestive disorders, "spasm" or colic, upset stomach, flatulence (gas), ulcers, and
gastrointestinal irritation (53). Chamomile is especially helpful in dispelling gas, soothing
the stomach, and relaxing the muscles that move food through the intestines. The protective
effect of a commercial preparation (STW5, Iberogast), containing the extracts of bitter
candy tuft, lemon balm leaf, chamomile flower, caraway fruit, peppermint leaf, liquorice
root, Angelica root, milk thistle fruit and greater celandine herb, against the development of
gastric ulcers has been previously reported (54). STW5 extracts produced a dose dependent
anti-ulcerogenic effect associated with a reduced acid output, an increased mucin secretion,
an increase in prostaglandin E (2) release and a decrease in leukotrienes. The results
obtained demonstrated that STW5 not only lowered gastric acidity as effectively as a
commercial antacid, but was more effective in inhibiting secondary hyperacidity (54).
5.8 Hemorrhoids
Studies suggest that chamomile ointment may improve hemorrhoids. Tinctures of
chamomile can also be used in a sitz bath format. Tincture of Roman chamomile may reduce
inflammation associated with hemorrhoids (55,56).
5.9 Health Promotion
It has been claimed that consumption of chamomile tea boosts the immune system and helps
fight infections associated with colds. The health promoting benefits of chamomile was
assessed in a study which involved fourteen volunteers who each drank five cups of the
herbal tea daily for two consecutive weeks. Daily urine samples were taken and tested
throughout the study, both before and after drinking chamomile tea. Drinking chamomile
was associated with a significant increase in urinary levels of hippurate and glycine, which
have been associated with increased antibacterial activity (57). In another study, chamomile
relieved hypertensive symptoms and decreased the systolic blood pressure significantly,
increasing urinary output (58). Additional studies are needed before a more definitive link
between chamomile and its alleged health benefits can be established.
5.10 Inflammatory conditions
Inflammation is associated with many gastrointestinal disorders complaints, such as
esophageal reflux, diverticular disease, and inflammatory disease (59–61). Studies in
preclinical models suggest that chamomile inhibits Helicobacter pylori, the bacteria that can
contribute to stomach ulcers (60). Chamomile is believed to be helpful in reducing smooth
muscle spasms associated with various gastrointestinal inflammatory disorders. Chamomile
is often used to treat mild skin irritations, including sunburn, rashes, sores and even eye
inflammations (62–65) but its value in treating these conditions has not been shown with
evidence-based research.
5.11 Mucositis
Mouth ulcers are a common condition with a variety of etiologies (66). Stomatitis is a major
dose-limiting toxicity from bolus 5-fluorouracil-based (5-FU) chemotherapy regimens. A
double-blind, placebo-controlled clinical trial including 164 patients was conducted (22).
Patients were entered into the study at the time of their first cycle of 5-FU-based
chemotherapy and were randomized to receive a chamomile or placebo mouthwash thrice
daily for 14 days. There was no suggestion of any stomatitis difference between patients
randomized to either protocol arm. There was also no suggestion of toxicity. Similar results
were obtained with another prospective trial on chamomile in this situation. Data obtained
from these clinical trials did not support the pre study hypothesis that chamomile could
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decrease 5-FU-induced stomatitis. The results remain unclear if chamomile is helpful in this
5.12 Osteoporosis
Osteoporosis is a metabolic bone disease resulting from low bone mass (osteopenia) due to
excessive bone resorption. Sufferers are prone to bone fractures from relatively minor
trauma. Agents which include selective estrogen receptor modulators or SERMs,
biphosphonates, calcitonin are frequently used to prevent bone loss. To prevent bone loss
that occurs with increasing age, chamomile extract was evaluated for its ability to stimulate
the differentiation and mineralization of osteoblastic cells. Chamomile extract was shown to
stimulate osteoblastic cell differentiation and to exhibit an anti-estrogenic effect, suggesting
an estrogen receptor-related mechanism (67). However, further studies are needed before it
can be considered for clinical use.
5.13 Sleep aid/sedation
Traditionally, chamomile preparations such as tea and essential oil aromatherapy have been
used to treat insomnia and to induce sedation (calming effects). Chamomile is widely
regarded as a mild tranquillizer and sleep-inducer. Sedative effects may be due to the
flavonoid, apigenin that binds to benzodiazepine receptors in the brain (68). Studies in
preclinical models have shown anticonvulsant and CNS depressant effects respectively.
Clinical trials are notable for their absence, although ten cardiac patients are reported to have
immediately fallen into a deep sleep lasting for 90 minutes after drinking chamomile tea
(47). Chamomile extracts exhibit benzodiazepine-like hypnotic activity (69). In another
study, inhalation of the vapor of chamomile oil reduced a stress-induced increase in plasma
adrenocorticotropic hormone (ACTH) levels. Diazepam, co-administered with the
chamomile oil vapor, further reduced ACTH levels, while flumazenile, a BDZ antagonist
blocked the effect of chamomile oil vapor on ACTH. According to Paladini et al. (70), the
separation index (ratio between the maximal anxiolytic dose and the minimal sedative dose)
for diazepam is 3 while for apigenin it is 10. Compounds, other than apigenin, present in
extracts of chamomile can also bind BDZ and GABA receptors in the brain and might be
responsible for some sedative effect; however, many of these compounds are as yet
5.14 Anxiety and seizure
Chamomile has been reported in the treatment of generalized anxiety disorder (GAD). But
the reports seem contradictory as an earlier report suggests that German chamomile showed
significant inhibition of GAD activity (71). The recent results from the controlled clinical
trial on chamomile extract for GAD suggests that it may have modest anxiolytic activity in
patients with mild to moderate GAD (72). Extracts of chamomile (M. recutita) possess
suitable effects on seizure induced by picrotoxin (73). Furthermore, apigenin has been
shown to reduce the latency in the onset of picrotoxin-induced convulsions and reduction in
locomotor activity but did not demonstrate any anxiolytic, myorelaxant, or anticonvulsant
activities (16).
5.15 Diabetes
Studies suggest that chamomile ameliorates hyperglycemia and diabetic complications by
suppressing blood sugar levels, increasing liver glycogen storage and inhibition of sorbitol
in the human erythrocytes (74). The pharmacological activity of chamomile extract has
shown to be independent of insulin secretion (75), and studies further reveal its protective
effect on pancreatic beta cells in diminishing hyperglycemia-related oxidative stress (76).
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Additional studies are required to evaluate the usefulness of chamomile in managing
5.16 Sore throat/hoarseness
The efficacy of lubrication of the endo-tracheal tube cuff with chamomile before intubation
on postoperative sore throat and hoarseness was determined in a randomized double-blind
study. 161 patients whose American Society of Anesthesiologists (ASA) physical status was
I or II, and undergoing elective surgical, orthopedic, gynecological or urological surgeries
were divided in two groups. The study group received 10 puffs of chamomile extract
(Kamillosan M spray, total 370 mg of Chamomile extract) at the site of the cuff of the
endotracheal tube for lubrication, while the control group did not receive any lubrication
before intubations. Standard general anesthesia with tracheal intubations was given in both
groups. 41 out of 81 patients (50.6%) in the chamomile group reported no postoperative sore
throat in the post-anesthesia care unit compared with 45 out of 80 patients (56.3%) in the
control group. Postoperative sore throat and hoarseness both in the post-anesthesia care unit
and at 24 h post-operation were not statistically different. Lubrication of endo-tracheal tube
cuff with chamomile extract spray before intubations can not prevent post operative sore
throat and hoarseness (77). Similar results were obtained in another double blind study (78).
5.17 Vaginitis
Vaginal inflammation is common in women of all ages. Vaginitis is associated with itching,
vaginal discharge, or pain with urination. Atrophic vaginitis most commonly occurs in
menopausal and postmenopausal women, and its occurrence is often associated with reduced
levels of estrogen. Chamomile douche may improve symptoms of vaginitis with few side
effects (79). There is insufficient research data to allow conclusions concerning possible
potential benefits of chamomile for this condition.
5.18 Wound healing
The efficacy of topical use of chamomile to enhance wound healing was evaluated in a
double-blind trial on 14 patients who underwent dermabrasion of tattoos. The effects on
drying and epithelialization were observed, and chamomile was judged to be statistically
efficacious in producing wound drying and in speeding epithelialization (80). Antimicrobial
activity of the extract against various microorganisms was also assessed. The test group, on
day 15, exhibited a greater reduction in the wound area when compared with the controls
(61 % versus 48%), faster epithelialization and a significantly higher wound-breaking
strength. In addition, wet and dry granulation tissue weight and hydroxyproline content were
significantly higher. The increased rate of wound contraction, together with the increased
wound-breaking strength, hydroxyproline content and histological observations, support the
use of M. recutita in wound management (81). Recent studies suggest that chamomile
caused complete wound healing faster than corticosteroids (82). However, further studies are
needed before it can be considered for clinical use.
5.19 Quality-of-life in cancer patients
Essential oils obtained from Roman chamomile are the basic ingredients of aromatherapy.
Clinical trials of aromatherapy in cancer patients have shown no statistically significant
differences between treated and untreated patients (83). Another pilot study investigated the
effects of aromatherapy massage on the anxiety and self-esteem experience in Korean
elderly women. A quasi-experimental, control group, pretest-posttest design used 36 elderly
females: 16 in the experimental group and 20 in the control group. Aromatherapy massage
using lavender, chamomile, rosemary, and lemon was given to the experimental group only.
Each massage session lasted 20 min, and was performed 3 times per week for two 3-week
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periods with an intervening 1-week break. The intervention produced significant differences
in the anxiety and self-esteem. These results suggest that aromatherapy massage exerts
positive effects on anxiety and self-esteem (84–86). However, more objective, clinical
measures should be applied in a future study with a randomized placebo-controlled design.
A relatively low percentage of people are sensitive to chamomile and develop allergic
reactions (87). People sensitive to ragweed and chrysanthemums or other members of the
Compositae family are more prone to develop contact allergies to chamomile, especially if
they take other drugs that help to trigger the sensitization. A large-scale clinical trial was
conducted in Hamburg, Germany, between 1985 and 1991 to study the development of
contact dermatitis secondary to exposure to a mixture of components derived from the
Compositae family. Twelve species of the Compositae family, including German
chamomile, were selected and tested individually when the mixture induced allergic
reactions. During the study, 3,851 individuals were tested using a patch with the plant
extract (88). Of these patients, 118 (3.1%) experienced an allergic reaction. Further tests
revealed that feverfew elicited the most allergic reactions (70.1% of patients) followed by
chrysanthemums (63.6%) and tansy (60.8%). Chamomile fell in the middle range (56.5%).
A study involving 686 subjects exposed either to a sesquiterpene lactone mixture or a
mixture of Compositae extracts led to allergic reactions in 4.5% of subjects (89). In another
study it was shown that eye washing with chamomile tea in hay fever patients who have
conjunctivitis exacerbates the eye inflammation, whereas no worsening of eye inflammation
was noted when chamomile tea was ingested orally (90). Chamomile is listed on the FDA's
GRAS (generally recognized as safe) list. It is possible that some reports of allergic
reactions to chamomile may be due to contamination of chamomile by "dog chamomile," a
highly allergenic and bad-tasting plant of similar appearance. Evidence of cross-reactivity of
chamomile with other drugs is not well documented, and further study of this issue is needed
prior to reaching conclusions. Safety in young children, pregnant or nursing women, or
those with liver or kidney disease has not been established, although there have not been any
credible reports of toxicity caused by this common beverage tea.
Chamomile has been used as an herbal medication since ancient times, is still popular today
and probably will continue to be used in the future because it contains various bioactive
phytochemicals that could provide therapeutic effects. Chamomile can help in improving
cardiovascular conditions, stimulate immune system and provide some protection against
cancer. Establishing whether or not therapeutic effects of chamomile are beneficial to
patients will require research and generation of scientific evidence. There is a need for
continued efforts that focuses on pre-clinical studies with chamomile involving animal
models of various diseases. This may then be consequently validated in clinical trials that
will help in developing chamomile as a promising therapeutic agent. Without such evidence,
it will remain unclear whether these untested and unproven medical treatments are truly
beneficial. It is advisable that the discriminate and proper use of chamomile preparations
could be safe and provide therapeutic benefits however the indiscriminate or improper use
can be unsafe and harmful.
ACTH Adrenocorticotropic hormone
ASA American Society of Anesthesiologists
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BDZ benzodiazepine
CAM Complementary and alternative medicine
COX cyclooxygenase
5-FU 5-fluorouracil
GABA gamma-aminobutyric acid
GAD generalized anxiety disorder
LPS Lipopolysaccharide
SERM Selective estrogen receptor modulators
The original work from author’s laboratory outlined in this review was supported by United States Public Health
Service Grants RO1 AT002709 and RO1 CA108512
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... Body hydration is not the only health contribution that beverages make, many beverages, such as fruit juices and smoothies, can provide essential vitamins, minerals, and antioxidants [7,8] that support the body's immune system and overall vitality. Drinks like milk provide calcium and vitamin D [9], which are crucial for maintaining strong and healthy bones, and certain beverages, like herbal teas, can aid in digestion and soothe gastrointestinal discomfort [10,11]. Certain beverages, like green tea and red wine (in 1. ...
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Beverages and drinks play a significant role in maintaining the integral health of individuals. The aim of this study is to discover the pattern of beverage consumption in different groups of the Spanish population and to investigate its relationship with other nutritional variables and habits. To achieve the objectives, an observational, descriptive and cross-sectional study was conducted. For data collection, a questionnaire was designed and validated that explored different beverage and food consumption variables as well as socio-demographic and lifestyle variables. The instrument was disseminated, among the Spanish young adult population, through snowball sampling using social networks, collecting a sample of 17,541 valid surveys. Bivariate comparative analyses and correlation analyses were performed, and finally, the principal component analysis (PCA) method was used in order to study the relationships between variables related to drinking and health. The main results show significant differences in the pattern of beverage consumption between the socio-demographic variables of sex, age and educational level, as well as between different areas of Spain, while the PCA model shows the relationship between the consumption of sugar-sweetened beverages with the Healthy Nutrition Index of the population and sport practice. Based on the results of the study, the following conclusions were reached: the beverage consumption pattern of the Spanish population is affected by socio-demographic variables. Healthier drinking habits affect the nutrition and health of the population.
... Di antara sekian banyak senyawa fenolik, apigenin merupakan salah satu senyawa yang paling terkenal karena memiliki karakteristik nutrisional dan organoleptik yang tak terhitung jumlahnya. Namun, yang lebih menarik lagi adalah apigenin juga dapat berkontribusi terhadap peningkatan kesehatan manusia, sehingga berpotensi untuk dilakukan pengembangan dalam formulasi nutrasetikal sebagai alternatif terapi farmakologi untuk mengurangi risiko terjadinya efek samping dari penggunaan soporific drugs dalam jangka waktu yang panjang [3], [15]. Apigenin dapat menginduksi relaksasi otot dan sedasi tergantung pada dosisnya serta berperan aktif sebagai antioksidan, anti-inflamasi, anti-amiloidogenik, pelindung saraf, kemoprevensi, dan zat peningkat kognisi dengan potensi yang menarik dalam pengobatan maupun pencegahan penyakit Alzheimer [16], [17]. ...
Tidur merupakan keadaan dimana tubuh dan otak mengalami proses pemulihan yang sangat penting terhadap pencapaian kesehatan optimal, serta merupakan salah satu kebutuhan dasar manusia. Belakangan ini, ditemukan 21,8% penduduk dari 4.005 orang memiliki masalah tidur akut yang disebabkan karena terjadinya penurunan kualitas tidur. Kualitas tidur yang buruk dapat menyebabkan gangguan fisiologis dan psikologis. Salah satu bahan yang digunakan untuk meningkatkan kualitas tidur yakni bunga chamomile karena kandungan senyawa apigenin didalamnya. Tujuan dari penelitian ini adalah untuk mengetahui efektivitas sediaan farmasi bunga chamomile terhadap peningkatan kualitas tidur. Metode yang digunakan adalah literature review menggunakan jurnal internasional dan jurnal nasional terindeks. Artikel yang memenuhi kriteria kemudian dianalisis dan dikaji secara utuh, serta disajikan dalam bentuk review studi literatur ilmiah. Diperoleh hasil bahwa bunga chamomile berpotensi digunakan sebagai sediaan farmasi nutrasetikal karena adanya senyawa apigenin yang memiliki aktivitas sedative. Simpulan menunjukkan bahwa apigenin akan mengikat reseptor GABA A untuk merelaksasikan otot sehingga dapat merangsang timbulnya rasa kantuk serta meningkatkan kualitas tidur.
... Chitosan, alginate, and proteins like albumin are some of the most extensively studied natural polymers in polymeric nanoparticles for drug delivery [50]. Several synthetic polymers have been extensively studied to produce polymeric nanoparticles, with polylactide-polyglycolide, polylactide, polycaprolactones, and polyacrylates being some of the most widely explored [31]. Polymer-based nanoparticles have attracted much attention in various applications, particularly drug delivery systems. ...
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This article presents a comprehensive overview of the utilisation of nanotechnology in the cosmetics industry, with a specific focus on developing nanoparticles for the efficient delivery of active ingredients through skin penetration. The review delves into incorporating natural ingredients in cosmetics, exploring their therapeutic properties and the advantages and limitations associated with their use. Furthermore, the article examines the benefits of integrating natural ingredients into skincare products to enhance skin conditions, highlighting the application of nonfibrous technology in areas such as UV protection, anti-ageing effects, moisturisation improvement, and wound healing. Ultimately, the article emphasises the immense potential of nanotechnology to create innovative opportunities and positive societal impacts across various industries.
... axiety activity used for treating the symptoms of dysmenorrhea [32]. Numerous bioactive substances found in chamomile, such as chamazulene and flavonoids, are thought to be responsible for the herb's anti-inflammatory and muscle-relaxing effects [33]. These characteristics make chamomile a viable option for reducing pain and discomfort brought on by dysmenorrhea. ...
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The agonising disorder known as dysmenorrhea, which is characterized by painful menstruation, affects women all over the world. Due to their apparent efficacy and lack of side effects, traditional and herbal treatments for the management of dysmenorrhea have attracted increasing interest in recent years. The goal of this review is to offer a thorough examination of the most recent scientific research on the use of herbal remedies for the treatment of dysmenorrhea. We thoroughly investigate a wide range of medicinal plants, their active ingredients, their modes of action, and the clinical data demonstrating their effectiveness. This review emphasises the potential of medicinal plants as alternative or complementary options for the management of dysmenorrhea through an in-depth examination of botanical interventions. The dearth of comprehensive clinical trials and disparities in study design, however, highlight the need for more investigation into the safety and effectiveness of these therapies. This study provides a helpful resource for healthcare professionals, researchers, and individuals looking for alternative methods to lessen the burden of dysmenorrhea by highlighting the knowledge gaps now in existence and providing insights into prospective future research areas.
... axiety activity used for treating the symptoms of dysmenorrhea [32]. Numerous bioactive substances found in chamomile, such as chamazulene and flavonoids, are thought to be responsible for the herb's anti-inflammatory and muscle-relaxing effects [33]. These characteristics make chamomile a viable option for reducing pain and discomfort brought on by dysmenorrhea. ...
... CHM is an aromatic plant rich in volatile constituents, e.g., chamazulene and α-terpineol. However, the main volatile constituent of Chamomile is the essential oil terpenoid α-bisabolol 11 . In addition, flavonoids and phenolic acids such as caffeic acid, luteolin, luteolin-7-O-glucoside apigenin, and apigenin-7-O-glucoside were detected in the polar extracts of Chamomile 12 . ...
Objective. Increase the effectiveness of complex therapy for patients with telogen alopecia with simultaneous use of the drug «Volvit tablets» (biotin 5 mg) inside and «Volvit intensive care shampoo» with biotin externally. Materials and methods. Patients with telogen alopecia, aged 22 to 40 years, who had complaints and a history of the disease (time of onset of increased hair loss, connection of baldness with stress, medication, viral infection, etc.) were under observation. The main diagnostic measures included: pull test, dermatoscopy, trichoscopy, trichogram, laboratory tests (general blood test, general urine test, biochemical blood test; basic trace elements and vitamins, thyroid gland research), scalp biopsy indicated. Consultations with an endocrinologist, psychotherapist, hematologist and other specialists were scheduled. Results and discussion. On the basis of the analysis of literary sources and own clinical and laboratory studies, a complex therapy of diffuse telogen alopecia was developed with the simultaneous appointment of the drug «Volvit tablets» (biotin 5 mg) and «Volvit intensive care shampoo» with biotin, which has a dual effect (treatment from the inside and cosmetic care behind the hair and scalp from the outside). The diagnosis of diffuse telogen alopecia was established on the basis of the clinical picture of the disease and laboratory diagnostic data. Clinical symptoms in patients with telogen alopecia are manifested by uniform, intense hair loss over the entire head, which is noticed after washing the head and combing, when a lot of hair that has fallen out remains. After examining the patient, an individual treatment plan was drawn up, taking into account the identified factors of the disease and accompanying pathology. One of the most common causes of hair loss is an insufficient amount of biotin in the body, and the causes of a decrease in the amount of biotin in the body are stressful situations, an unbalanced diet with an insufficient amount of biotin in products, intestinal dysbacteriosis, diseases of internal organs, disorders of the endocrine system, transferred viral diseases, taking antibiotics and other. Taking into account the above, in the complex therapy of patients with diffuse telogen alopecia, the drug «Volvit tablets» (biotin 5 mg) inside 5 mg once a day and «Volvit intensive care shampoo with biotin» were prescribed at the same time, as a result, good therapeutic results were achieved. Conclusions. Complex therapy of diffuse telogen alopecia with the simultaneous appointment of the drug «Volvit tablets» (biotin 5 mg) internally and «Volvit intensive care shampoo» with biotin externally helps to stop hair loss, restores the hair follicles to their normal function, is expedient in view of effectiveness and safety and can to be recommended for wide implementation in the practical work of doctors
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Natural health products (NHP) have emerged as a potential symptomatic therapeutic approach for persons with Parkinson's disease (PwP). The objective of this study was to quantify the prevalence of ever use of NHP, interest in plant-based NHP, awareness of potential herb-drug interactions, and how often NHP use was discussed by PwP with their healthcare professionals. We addressed these objectives by embedding a cross-sectional 4-item survey within a large population-based cohort of PwP (PRIME-NL study). Sixty-five percent (n=367) of the 566 participants who were contacted completed the survey. Of those participants, 132 (36%) reported having used NHP to alleviate Parkinson's disease (PD)-related symptoms, with coffee, cannabis and turmeric being the most popular. Overall, 12% (n=44) of PwP had used at least one NHP other than coffee or cannabis. Furthermore, 71% (n=259) participants expressed an interest in exploring the use of NHP, but only 39% (n=51) of NHP users were aware that these products could interact with PD medication. Finally, only 39% (n=51) of NHP users had discussed the use of NHP with their neurologist or PD nurse specialist. In a sensitivity analysis, we conservatively assumed that all non-responders to the survey had never used NHP and had no interest in exploring NHP. This rendered an estimated prevalence of NHP use of 23% and an estimated interest in exploring NHP of 46%. In conclusion, over one in three PwP has used NHP to alleviate symptoms of PD and the majority of PwP is interested in exploring the use of plant-based NHP. Most users had not discussed the intake of NHP with their PD healthcare professional and were unaware that these products could interact with PD medication. This study supports the need for evidence-based research on the properties of plant-derived therapeutics.
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Aromatherapy, a part of herbology, is one of today's rapid-developing treatments. Fundamental oils are best utilized asback rubs, shower oils, or inward breaths. It is often accounted for that fragrance-based treatment leaves one inclination elevated,animated, empowered, or restored, contingent upon the oil utilized. At the point when breathed in, the different smells infiltratethe circulatory system through the lungs, causing physiologic changes. Aromatherapy is a form of alternative medicine.Aromatherapy is becoming increasingly popular, and there are clear indications that it should be used. It is one of thecomplementary therapies for anxiety reduction. Derived aroma molecules from essential oils contain curative and preventive usesin the medicine department. Although the perception and reaction to essential oils appear to differ significantly between men andwomen, aromatherapy benefits people of all ages. This article mainly focuses on a narrative review of aromatherapy, Derivatives,and uses of essential oils with a widened horizon in Aromatology.
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Flowers have played a significant role in society, focusing on their aesthetic value rather than their food potential. This study's goal was to look into flowering plants for everything from health benefits to other possible applications. This review presents detailed information on 119 species of flowers with agri-food and health relevance. Data were collected on their family, species, common name, commonly used plant part, bioremediation applications, main chemical compounds, medicinal and gastronomic uses, and concentration of bioactive compounds such as carotenoids and phenolic compounds. In this respect, 87% of the floral species studied contain some toxic compounds, sometimes making them inedible, but specific molecules from these species have been used in medicine. Seventy-six percent can be consumed in low doses by infusion. In addition, 97% of the species studied are reported to have medicinal uses (32% immune system), and 63% could be used in the bioremediation of contaminated environments. Significantly, more than 50% of the species were only analysed for total concentrations of carotenoids and phenolic compounds, indicating a significant gap in identifying specific molecules of these bioactive compounds. These potential sources of bioactive compounds could transform the health and nutraceutical industries, offering innovative approaches to combat oxidative stress and promote optimal well-being.
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The presence of benzodiazepine-like substances in dried flower heads of Matricaria chamomilla was investigated. After extraction and HPLC purification we tested several fractions for their ability to displace in vitro [3H]Flunitrazepam bound to its receptors in rat cerebellar membranes, [3H]Muscimol linked to GABA receptors in rat cortical membrane preparations and [3H]RO 5-4864 specifically bound to the so-called 'peripheral' benzodiazepine binding sites present in membrane preparations from rat adrenal glands. Few of these fractions displaced both central and peripheral benzodiazepine binding sites and GABA receptors, too. As regards this last activity, by further HPLC analysis we identified GABA as the main agent responsible for the displacing effect. Some of the extracted fractions, not containing GABA, were intracerebronventricularly injected in rats and produced a statistically significant reduction of the locomotor activity. Ongoing experiment by mass spectrometric technique will help in the identification of the benzodiazepine-like compounds present in the extract of Matricaria chamomilla responsible for its sedative effect.
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The major flavonoids in the white florets of chamomile (Chamomilla recutita [L.] Rauschert) were rapidly purified using a combination of polyamide solid-phase extraction and preparative HPLC. From the combined LC/MS, LC/MS/MS, and NMR data the apigenin glucosides were identified as apigenin 7-O-glucoside (Ap-7-Glc), Ap-7-(6″-malonyl-Glc), Ap-7-(6″-acetyl-Glc), Ap-7-(6″-caffeoyl-Glc), Ap-7-(4″-acetyl-Glc), Ap-7-(4″-acetyl,6″-malonyl-Glc), and a partially characterised apigenin-7-(mono-acetyl/mono-malonylglucoside) isomer. Malonyl and caffeoyl derivatives of Ap-7-Glc have not previously been identified in chamomile. The two mono-acetyl/mono-malonyl flavonoids have not previously been reported in any plant species. These acylated glucosides are unstable and degrade to form acetylated compounds or Ap-7-Glc. The degradation products formed are dependent on the extraction and storage conditions, i.e. temperature, pH and solvent.
Does Echinacea fight the common cold? Does St. John's Wort (SJW) really counteract depression? What about chondroitin for joint health? Today's healthcare professionals are increasingly confronted with questions from patients who want to use herbal supplements to treat various conditions. A critical and scientific assessment of medicinal plant research by an internationally recognized researcher and writer in the field, Tyler's Herbs of Choice: The Therapeutic Use of Phytomedicinals, Third Edition combines the scientific aspects of herbal medicine, phytomedicine, and pharmacognosy with the modern clinical trials that support the rationale for using plant products in healthcare. A Decade's Worth of Updates The original edition of this volume was authored by the late Professor Varro E. Tyler, a true giant in the field of pharmacognosy and pharmacy education. Following in Tyler's footsteps, Dennis V.C. Awang, co-editor of the journal Phytomedicine, recognized the need for a revised third edition, in light of how quickly the clinical literature surrounding the dietary supplement market is growing. Millions of consumers are demanding natural treatment options from their doctors and pharmacies in a variety of forms, from herbal teas to tinctures and capsules. Tyler's Herbs of Choice: The Therapeutic Use of Phytomedicinals, Third Edition effectively fosters understanding in patients and practitioners of the role that herbs and phytomedicinal products can play in both self-care and healthcare.
Colic has been described using the "rule of 3": crying for at least 3 hours per day on at least 3 days per week for at least 3 weeks. The distinction can be subtle; a normal infant can cry more than 2 hours per day. This syndrome has its onset typically in the first few weeks of life. It spontaneously resolves by age 4 to 6 months. Prevalence depends on the definition used for colic; approximately 5% to 25% of infants meet some reasonable definition of colic. The cause of infantile colic is poorly understood. Although clinicians tend to focus on a likely gastrointestinal cause, neuropsychological issues, food allergy, and parenting misadventures are also potential contributing factors. There are myriad strategies-ranging from craniosacral osteopathic manipulation to car ride simulation-offered for dealing with infantile colic. Although none of these treatments has been validated in rigorous studies, the available evidence offers tentative support for 3 strategies: (1) a trial of a hypoallergenic (protein hydrolysate) formula (for formula fed infants), (2) a low-allergen maternal diet (for breastfeeding mothers), and (3) reduced stimulation of the infant. A systematic review analyzed controlled clinical trials lasting at least 3 days involving infants less than 6 months of age who cried excessively. Twenty-seven studies were included; the outcome measure was colic symptoms, typically reported as duration of crying. Two reports studying hypoallergenic (protein hydrolysate) formula in nearly 130 infants found an effect size of 0.22 (95% confidence interval [CI], 0.10-0.34) for the hypoallergenic formula. Additionally, 3 behavioral trials (involving nearly 200 infants) revealed the benefits of reduced stimulation of the colicky infant (effect size of 0.48; 95% CI, 0.23-0.74). A more recent systematic review followed a similar high-quality search strategy and identified 22 articles, and reported a number needed to treat (NNT) of 6 for the 2 hypoallergenic formula studies identified in the previous review. Because of concern regarding the quality of the behavioral studies involving infants with colic, the authors of this second review only included 1 small (42 patients) trial of decreased stimulation, which resulted in a relative risk (RR) of 1.87 (95% CI, 1.04-3.34) and a NNT of 2. There was some inconclusive evidence to suggest benefit to dietary adjustment for breastfeeding mothers (specifically, the avoidance of cow's milk and other potential allergens like nuts, eggs, and wheat). A recent randomized controlled trial confirmed the value of this approach by showing significant improvement in distress scores of infants whose mothers followed a low-allergen diet (excluding dairy, soy, wheat, eggs, peanuts, tree nuts, and fish) for 7 days. This well-designed study included 107 patients (a relatively large sample in the published research about colic), and showed an absolute risk reduction of 37% (NNT=3) for those mothers following the challenge. A small RCT (43 patients) suggested efficacy in the substitution of a whey hydrolysate formula in place of cow's milk-based formula for infants with colic (casein hydrolysate formula has been more widely studied), but there continues to be controversy regarding the preferred protein hydrolysate formula (whey vs casein) in the treatment of colic. Several medications have been tested in RCTs; only dicyclomine has shown an effect in a few small RCTs. However, there have been reports of apnea and other serious, although infrequent, adverse effects. For that reason, the manufacturer has contraindicated the use of this medication in infants aged <6 months. A small (n=68) study of an herbal tea showed reduced symptoms (RR=0.57 favoring the active tea), although the mean volume of tea consumption (32 mL/kg/d) is a nutritional concern in this age group. No adverse events were noted, but the small sample size limits the ability to detect any but the most common events.
Introduction: The common chamomile (Isocarpha Cubana Blake) is a plant commonly used by Cuban people. It has the same properties scientifically tested on the sweet chamomile (Matricaria Recutita, L.). A few studies have been related to it and none has demonstrated that the plant has the properties attributed to it. A preliminary pharmacognostic study dealt favorably with the possible similarities of both plants. It was the basis that determined the study of its pre-clinical pharmacological effects. Materials and methods: The anti-inflammatory action was evaluated by means of the model of induced inflammation by carragenin which values the acute effect. It was completed with the two other models of inflammation: that of granuloma to evaluate the chronic effect of the extract and that of auricular edema to evaluate the topic anti-inflammatory action of the cream. Taking into account the wide use of this plant by our population as an anti-diarrheic and digestive medication, its effect on the intestinal duct was also studied. Results: The fluid extract diminished the percentage of acute inflammation produced by carragenin in three dose levels, being this dose effect dependent and similar to that of indomethacin. In the same way, it inhibited significantly the production of granulomatous tissue in the model of chronic inflammation. However, the chamomile cream at 5 % was not able to diminish, in a topic way, the inflammatory effect produced by the croton oil. While studying its activity on the intestinal tract the extract acted out as an anti-diarrheic medication, being able to decrease the laxative effect of glycerin. Conclusions: The fluid extract of the common chamomile demonstrated to have acute and chronic anti-inflammatory action as well as anti-diarrheic effect while the chamomile cream at 5 % did not have anti-inflammatory effect in a topic way.