Posaconazole as part of the antifungal armamentarium in the intensive care unit - case reports from a surgical ICU
Pharmacy Department, University Hospital of Heidelberg, Heidelberg, Germany. Mycoses
(Impact Factor: 2.24).
01/2011; 54 Suppl 1(s1):45-8. DOI: 10.1111/j.1439-0507.2010.01986.x
The authors describe two cases of successful and safe posaconazole use in patients of a surgical intensive care unit of a university hospital.
Available from: Torsten Hoppe-Tichy
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ABSTRACT: Abdominal surgery may affect intestinal absorption and the resulting levels of posaconazole in the blood. We measured plasma
posaconazole levels in surgical intensive care unit (SICU) patients and tried to develop a predictive population pharmacokinetics
model. A total of 270 samples from 15 patients receiving posaconazole via nasogastric tube were measured by high-performance
liquid chromatography (HPLC). SICU patients showed lower plasma drug concentrations, a higher apparent clearance, and a higher
volume of distribution than those in hematology patients, possibly due to poor absorption.
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