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Serum unconjugated bisphenol A concentrations in women may adversely influence oocyte quality during in vivo fertilization.

Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, California 94115-0916, USA.
Fertility and sterility (Impact Factor: 4.59). 12/2010; 95(5):1816-9. DOI: 10.1016/j.fertnstert.2010.11.008
Source: PubMed

ABSTRACT

Bisphenol A (BPA) is an endocrine disruptor with estrogenic properties that can adversely affect meiotic spindle assemblies. Our data indicate that BPA exposure in female patients may interfere with oocyte quality during IVF, as suggested by the inverse association between serum unconjugated BPA concentration and normal fertilization.

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Available from: Michael S Bloom
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    • "BPA toxicity has received much attention because it is suspected to be associated with adverse health outcomes, including reproductive dysfunction (reviewed in Caserta et al., 2014; Peretz et al., 2014; Rochester, 2013). Epidemiological studies of women have associated BPA exposure with polycystic ovary syndrome (Kandaraki et al., 2011), recurrent miscarriage (Sugiura-Ogasawara et al., 2005), premature delivery (Cantonwine et al., 2010), reduced ovarian response (Bloom et al., 2011; Ehrlich et al., 2012b; Mok-Lin et al., 2010), abnormal oocyte meiotic maturation (Machtinger et al., 2013), abnormal oocyte fertilization (Ehrlich et al., 2012b; Fujimoto et al., 2011), and implantation failure (Ehrlich et al., 2012a). In animal studies, neonatal or perinatal exposure to BPA has been reported to cause early puberty onset (Honma et al., 2002), irregular estrous cyclicity in adult life (Rubin et al., 2001; Wang et al., 2014), implantation failure (Varayoud et al., 2011; Xiao et al., 2011), and impaired meiotic maturation of the oocyte (Eichenlaub-Ritter et al., 2008; Hunt et al., 2003; Lawson et al., 2011; Susiarjo et al., 2007). "
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    ABSTRACT: Follicle growth culminates in ovulation, which allows for the expulsion of fertilizable oocytes and the formation of corpora lutea. Bisphenol A (BPA) is present in many consumer products, and it has been suggested that BPA impairs ovulation; however, the underlying mechanisms are unknown. Therefore, this study first evaluated whether BPA alters ovulation by affecting folliculogenesis, the number of corpora lutea or eggs shed to the oviduct, ovarian gonadotropin responsiveness, hormone levels, and estrous cyclicity. Because it has been suggested (but not directly confirmed) that BPA exerts toxic effects on the fertilization ability of oocytes, a second aim was to evaluate whether BPA impacts the oocyte fertilization rate using an in vitro fertilization assay and mating. The possible effects on early zygote development were also examined. Young adult female C57BL/6J mice (39days old) were orally dosed with corn oil (vehicle) or 50μg/kgbw/day BPA for a period encompassing the first three reproductive cycles (12-15days). BPA exposure did not alter any parameters related to ovulation. Moreover, BPA exposure reduced the percentage of fertilized oocytes after either in vitro fertilization or mating, but it did not alter the zygotic stages. The data indicate that exposure to the reference dose of BPA does not impact ovulation but that it does influence the oocyte quality in terms of its fertilization ability.
    Full-text · Article · Oct 2015 · Toxicology and Applied Pharmacology
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    • "Several studies have investigated the impact of BPA on female reproductive and pregnancy outcomes (Galloway et al., 2010; Mok-Lin et al., 2010; Bloom et al., 2011a,b; Fujimoto et al., 2011; Ehrlich et al., 2012a,b). We previously reported that in women undergoing in vitro fertilization (IVF), urinary BPA concentrations were inversely associated with peak serum estradiol levels, number of oocytes at retrieval (overall and mature), and number of normally fertilized oocytes (Mok-Lin et al., 2010; Ehrlich et al., 2012b). "
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    ABSTRACT: Are urinary BPA concentrations associated with in vitro fertilization (IVF) outcomes among women attending an academic fertility center? Urinary BPA concentrations were not associated with adverse reproductive and pregnancy outcomes among women from a fertility clinic. Bisphenol A (BPA), an endocrine disruptor, is detected in the urine of most Americans. Although animal studies have demonstrated that BPA reduces female fertility through effects on the ovarian follicle and uterus, data from human populations are scarce and equivocal. This prospective cohort study between 2004 and 2012 at the Massachusetts General Hospital Fertility Center included 256 women (n = 375 IVF cycles) who provided up to two urine samples prior to oocyte retrieval (total N = 673). Study participants were women enrolled in the Environment and Reproductive Health (EARTH) Study. Intermediate and clinical end-points of IVF treatments were abstracted from electronic medical records. We used generalized linear mixed models with random intercepts to evaluate the association between urinary BPA concentrations and IVF outcomes adjusted by age, race, body mass index, smoking status and infertility diagnosis. The specific gravity-adjusted geometric mean of BPA was 1.87 µg/l, which is comparable to that for female participants in the National Health and Nutrition Examination Survey, 2011-2012. Urinary BPA concentrations were not associated with endometrial wall thickness, peak estradiol levels, proportion of high quality embryos or fertilization rates. Furthermore, there were no associations between urinary BPA concentrations and implantation, clinical pregnancy or live birth rates per initiated cycle or per embryo transfer. Although we did not find any associations between urinary BPA concentrations and IVF outcomes, the relation between BPA and endometrial wall thickness was modified by age. Younger women (<37 years old) had thicker endometrial thickness across increasing quartiles of urinary BPA concentrations, while older women (≥37 years old) had thinner endometrial thickness across increasing quartiles of urinary BPA concentrations. Limitations to this study include a possible misclassification of BPA exposure and difficulties in extrapolating the findings to the general population. Data on the relation between urinary BPA concentrations and reproductive outcomes remain scarce and additional research is needed to clarify its role in human reproduction. This work was supported by NIH grants R01ES022955, R01ES009718 and R01ES000002 from the National Institute of Environmental Health Sciences (NIEHS) and grant T32DK00770316 from the National Institute of Child Health and Human Development (NICHD). None of the authors has any conflicts of interest to declare. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. © The Author 2015. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
    Preview · Article · Jul 2015 · Human Reproduction
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    • "A few human studies have analyzed the association between urinary BPA levels and oocyte yield, maturation, and fertilization (see Supplemental Material, Table S2). In a small prospective study of 58 infertile women and 37 male partners under going intracytoplasmic sperm injection or conventional IVF, Fujimoto et al. (2011) found an association between serum BPA concentrations and oocyte maturation only among Asian women, but an overall correlation between increasing serum concentrations and the develop mental potential of human oocytes. In two publications from the same prospective cohort of 84 women (Mok-Lin et al. 2010) and 174 women (Ehrlich et al. 2012a) undergoing IVF, increasing urinary BPA concentration was associated with decreased numbers of retrieved oocytes, mature oocytes (MII), and normally fertilized oocytes (2PN). "
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    ABSTRACT: Background: In 2007, an expert panel reviewed associations between bisphenol A (BPA) exposure and reproductive health outcomes. Since then, new studies have been conducted on the impact of BPA on reproduction. Objective: In this review, we summarize data obtained since 2007, focusing on a) findings from human and animal studies, b) the effects of BPA on a variety of reproductive end points, and c) mechanisms of BPA action. Methods: We reviewed the literature published from 2007 to 2013 using a PubMed search based on keywords related to BPA and male and female reproduction. Discussion: Because BPA has been reported to affect the onset of meiosis in both animal and in vitro models, interfere with germ cell nest breakdown in animal models, accelerate follicle transition in several animal species, alter steroidogenesis in multiple animal models and women, and reduce oocyte quality in animal models and women undergoing in vitro fertilization (IVF), we consider it an ovarian toxicant. In addition, strong evidence suggests that BPA is a uterine toxicant because it impaired uterine endometrial proliferation, decreased uterine receptivity, and increased implantation failure in animal models. BPA exposure may be associated with adverse birth outcomes, hyperandrogenism, sexual dysfunction, and impaired implantation in humans, but additional studies are required to confirm these associations. Studies also suggest that BPA may be a testicular toxicant in animal models, but the data in humans are equivocal. Finally, insufficient evidence exists regarding effects of BPA on the oviduct, the placenta, and pubertal development. Conclusion: Based on reports that BPA impacts female reproduction and has the potential to affect male reproductive systems in humans and animals, we conclude that BPA is a reproductive toxicant.
    Full-text · Article · Jun 2014 · Environmental Health Perspectives
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