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    • "However, it is difficult to draw conclusions as to whether these differences represent varying prevalence of distinct subtypes and tumour grade between distinct age-cohorts or whether they reflect other age related differences [20]. More recent work by Anders has suggested that the gene expression patterns uniting the younger cohort may relate to an enrichment of basal-like tumours in this patient group [21]. Our data, using two independently derived expression measures of CIN, suggest that a molecular feature of tumours from younger patients with ER negative breast cancers may reflect structural or numerical CIN. "
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    ABSTRACT: Breast cancer in younger patients often presents with adverse histopathological features, including increased frequency of estrogen receptor negative and lymph node positive disease status. Chromosomal instability (CIN) is increasingly recognised as an important prognostic variable in solid tumours. In a breast cancer meta-analysis of 2423 patients we examine the relationship between clinicopathological parameters and two distinct chromosomal instability gene expression signatures in order to address whether younger age at diagnosis is associated with increased tumour genome instability. We find that CIN, assessed by the two independently derived CIN expression signatures, is significantly associated with increased tumour size, ER negative or HER2 positive disease, higher tumour grade and younger age at diagnosis in ER negative breast cancer. These data support the hypothesis that chromosomal instability may be a defining feature of breast cancer biology and clinical outcome.
    Full-text · Article · Jun 2011 · Oncotarget
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    ABSTRACT: Wir berichten über einen 71-jährigen Patienten mit einem zystischen Tumor im linken Oberbauch und lang andauernder Beschwerdesymptomatik in der Anamnese. Nach der klinischen und apparativen Diagnostik wird eine Laparotomie durchgeführt. Es erfolgt die komplette Exstirpation des Tumors mit Resektion der ersten Jejunumschlinge und Rekonstruktion der Darmpassage durch Handnahtanastomose. Der histologische Befund ergibt einen gastrointestinalen Stromatumor mit hohem Progressionsrisiko.
    No preview · Article · Apr 2012 · Der Chirurg
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    ABSTRACT: Breast cancer (BC) is the most common cancer in women in Western countries, showing a bimodal age distribution with peaks at 50 and 70 years. Multiple factors are encountered in the etiology of BC, including hereditary and hormonal causes. A few viruses, including MMTV, EBV and HPV have been reported to be associated with BC. This group previously described the presence of the measles virus (MV) in biopsies of patients with Hodgkin's lymphoma. The present study explored MV antigens in BC patients. A total of 131 patients with invasive BC diagnosed during the years 1998-2005 were studied using immunohistochemistry (IHC) for the presence of MV antigens, hemagglutinin and nucleoprotein. Clinicopathological parameters included age, stage, histological grade and the expression of estrogen and progesterone receptors, HER2/neu, p53, and Ki67. Hormone receptors and HER2/neu were positive in 54% and 18% of the tumors, respectively. Both MV antigens were detected in 64% of the tumors. All biopsies containing a DCIS component showed MV in DCIS in addition to invasive BC. In univariate analysis, MV correlated with estrogen receptor (p=0.018), low Ki67 index (<40%, p=0.029), low or intermediate grade (p=0.037), age under 50 years (p=0.039), progesterone receptor (p=0.043) and overexpression of p53 (p=0.049). In multivariate analysis, only grade (p=0.011), p53 (p=0.03) and age (p=0.041) remained associated with MV. This study provides evidence for the presence of MV antigens in a relatively large proportion of BC patients. MV was associated with younger age, lower histological grade and overexpression of p53, suggesting that it may play a role in the development of BC.
    No preview · Article · Mar 2011 · Anticancer research
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