Cell biology: Import and nuclear size

Nature (Impact Factor: 41.46). 11/2010; 468(7323):513-6. DOI: 10.1038/468513a
Source: PubMed


The size of a cell's nucleus is usually proportional to the size of the cell itself. How are the two linked? The answer lies, at least in part, in the import of one or more cytoplasmic cargoes into the nucleus.

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    • "Hepatocyte regeneration proceeds along a sequence of distinctive phases and requires priming of hepatocytes to achieve competence for proliferation, such as increasing synthesis of RNA and proteins. Thus, hepatocytes increase in size at the early stage of the cell cycle, and the change of nuclear size is proportional to the change of cellular size [39]. Generally, the nucleus increases in size from the time of its formation [40]. "
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