Adherence to nutritional recommendations and subsequent cognitive performance: findings from the prospective Supplementation with Antioxidant Vitamins and Minerals 2 (SU.VI.MAX 2) study

Unité de Recherche en Epidémiologie Nutritionnelle, U557 INSERM/U1125 Inra/Cnam/Université Paris 13, CRNH IdF, Bobigny, France.
American Journal of Clinical Nutrition (Impact Factor: 6.77). 01/2011; 93(1):200-10. DOI: 10.3945/ajcn.2010.29761
Source: PubMed


Few studies have investigated the long-term effect of overall nutritional recommendations on cognition.
In a French cohort of middle-aged adults, we evaluated the association between the French National Nutrition and Health Program (Program National Nutrition Santé) Guideline Score (PNNS-GS) assessed at baseline and cognitive performance evaluated 13 y later.
The PNNS-GS was estimated at baseline (1994-1996) (maximum score: 15 points) in 2135 subjects in the SU.VI.MAX (Supplementation with Antioxidant Vitamins and Minerals) study. We assessed cognitive performance of subjects in 2007-2009 via a battery of 4 neuropsychologic tests that included phonemic and semantic fluency, the RI-48 (rappel indicé-48 item) cued-recall test, the trail-making test, and forward and backward digit spans. A principal components analysis was performed to account for correlations in test scores. Multivariate linear regression models or analyses of covariance were also performed.
In a multivariate model, we observed a positive association between the PNNS-GS and the cued-recall test and semantic and phonemic fluency tasks, whereas no association was observed with digit spans. The principal components analysis revealed 2 factors interpreted as reflecting verbal memory and executive functioning. Better adherence to nutritional recommendations was significantly associated with the verbal memory factor (β = 0.41; 95% CI: 0.17, 0.64), whereas no association was shown with the executive functioning factor. Removing specific components from the PNNS-GS did not modify the findings.
This study suggests that strong compliance with nutritional recommendations in midlife is associated in elderly individuals with better verbal memory, which is a cognitive domain that is particularly vulnerable to pathologic aging and Alzheimer disease. This trial was registered at as NCT00272428.

Download full-text


Available from: Emmanuelle Kesse-Guyot, Aug 18, 2015
  • Source
    • "Our finding that maintained healthy dietary choice was associated with a slower rate of memory decline is consistent with the results of a recent systematic review, which highlighted that a diet high in saturated fat represents an increased risk of cognitive decline and subsequent dementia [6]. The emphasis on identifying specific nutrients associated with cognitive ability in later life, such as antioxidants (vitamin C, E, carotenoids, and polyphenols), minerals, and dietary lipids (total, trans, and saturated mono-and polyunsaturated fats) [56], is now giving way to studies of global diet quality indices, for guidance in modeling dietary risk in relation to cognitive performance [57, 58]. In this context general recommendations are made for high fruit and vegetable consumption and moderation of high-glycemic index foods as cardioprotective, with secondary benefits to cognitive ageing [59]. "
    [Show abstract] [Hide abstract]
    ABSTRACT: This study examined the association between smoking, physical activity and dietary choice at 36 and 43 years, and change in these lifestyle behaviors between these ages, and decline in verbal memory and visual search speed between 43 and 60-64 years in 1018 participants from MRC National Survey of Health and Development (NSHD, the British 1946 birth cohort). ANCOVA models were adjusted for sex, social class of origin, childhood cognition, educational attainment, adult social class, and depression; then the lifestyle behaviors were additionally mutually adjusted. Results showed that healthy dietary choice and physical activity were associated, respectively, with slower memory and visual search speed decline over 20 years, with evidence that increasing physical activity was important. Adopting positive health behaviors from early midlife may be beneficial in reducing the rate of cognitive decline and ultimately reducing the risk of dementia.
    Full-text · Article · Sep 2012 · Journal of aging research

  • No preview · Article · Jun 2011 · Current opinion in lipidology
  • [Show abstract] [Hide abstract]
    ABSTRACT: Current hypotheses suggest that intake of fruit and vegetables (FVs) protects against age-related cognitive impairment. We examined the 13-y association between FV intake and cognitive performance in a sample of French adults. A total of 2533 subjects aged 45-60 y at baseline, who were part of the Supplementation with Antioxidant Vitamins and Minerals 2 (SU.VI.MAX 2) cohort, were selected. FV intake was estimated at baseline in participants who had completed at least six 24-h dietary records. Cognitive performance was assessed 13 y after baseline and included an evaluation of verbal memory (RI-48 cued recall, semantic, and phonemic fluency tests) and executive function (trail-making and forward and backward digit span tests). Principal components analysis was performed to account for correlations in test scores. The relation between cognitive performance and quartiles of FV intake was assessed by multivariate linear regression analyses. Intakes of FVs (P-trend = 0.02), fruit alone (P-trend = 0.04), vitamin C-rich FVs (P-trend = 0.03), vitamin C (P-trend = 0.005), and vitamin E (P-trend = 0.04) were positively associated with verbal memory scores. In contrast, intakes of FVs (P-trend = 0.006), vegetables alone (P-trend = 0.03), and β-carotene-rich FVs (P-trend = 0.02) were negatively associated with executive functioning scores. FVs might have a differential effect on cognition according to groups of FVs and type of cognitive function. Further research using sensitive and reliable measures of various types of cognitive function is needed to clarify the effect of individual FV groups and nutrients. This trial is registered at as NCT00272428.
    No preview · Article · Sep 2011 · American Journal of Clinical Nutrition
Show more