Abuse in Childhood and Adolescence As a Predictor of Type 2 Diabetes in Adult Women

Connors Center for Women's Health and Gender Biology, Brigham and Women's Hospital/Harvard Medical School, Boston, Massachusetts, USA.
American journal of preventive medicine (Impact Factor: 4.53). 12/2010; 39(6):529-36. DOI: 10.1016/j.amepre.2010.09.007
Source: PubMed


Although child abuse is associated with obesity, it is not known whether early abuse increases risk of type 2 diabetes.
To investigate associations of child and adolescent abuse with adult diabetes.
Proportional hazards models were used to examine associations of lifetime abuse reported in 2001 with risk of diabetes from 1989 to 2005 among 67,853 women in the Nurses' Health Study II. Data were analyzed in 2009.
Child or teen physical abuse was reported by 54% and sexual abuse by 34% of participants. Models were adjusted for age, race, body type at age 5 years, and parental education and history of diabetes. Compared to women who reported no physical abuse, the hazards ratio (HR) was 1.03 (95% CI=0.91, 1.17) for mild physical abuse; 1.26 (1.14, 1.40) for moderate physical abuse; and 1.54 (1.34, 1.77) for severe physical abuse. Compared with women reporting no sexual abuse in childhood or adolescence, the HR was 1.16 (95% CI=1.05, 1.29) for unwanted sexual touching; 1.34 (1.13, 1.59) for one episode of forced sexual activity; and 1.69 (1.45, 1.97) for repeated forced sex. Adult BMI accounted for 60% (95% CI=32%, 87%) of the association of child and adolescent physical abuse and 64% (95% CI=38%, 91%) of the association of sexual abuse with diabetes.
Moderate to severe physical and sexual abuse in childhood and adolescence have dose-response associations with risk of type 2 diabetes among adult women. This excess risk is partially explained by the higher BMI of women with a history of early abuse.

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    • "For instance, childhood adversity, which may predispose individuals to and/or be the underlying cause of PTSD, predicts central obesity even when controlling for other risk factors such as gender, race, family history, smoking, diet, and exercise [13]. Similarly, early life stress has been linked with obesity, metabolic syndrome, cardiovascular disease and type 2 diabetes [14] [15] [16]. Inflammation appears to be higher in adults exposed to early life adversity, including increased levels of interleukin-6 (IL-6), C-reactive protein (CRP), and tumor necrosis factor (TNF), which may further contribute to risk of cardiovascular disease [17] [18]. "

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