The bioactivity and ion release of titanium-containing glass polyalkenoate cements for medical applications

ArticleinJournal of Materials Science Materials in Medicine 22(1):19-28 · November 2010with13 Reads
Impact Factor: 2.59 · DOI: 10.1007/s10856-010-4184-4 · Source: PubMed


    The ion release profiles and bioactivity of a series of Ti containing glass polyalkenoate cements. Characterization revealed each material to be amorphous with a T
    g in the region of 650–660°C. The network connectivity decreased (1.83–1.35) with the addition of TiO2 which was also evident with analysis by X-ray photoelectron spectroscopy. Ion release from cements were determined using atomic absorption spectroscopy for zinc (Zn2+), calcium (Ca2+), strontium (Sr2+), Silica (Si4+) and titanium (Ti4+). Ions such as Zn2+ (0.1–2.0 mg/l), Ca2+ (2.0–8.3 mg/l,) Sr2+ (0.1–3.9 mg/l), and Si4+ (14–90 mg/l) were tested over 1–30 days. No Ti4+ release was detected. Simulated body fluid revealed a CaP surface layer on each cement while cell culture testing of cement liquid extracts with TW-Z (5 mol% TiO2) produced the highest cell viability (161%) after 30 days. Direct contact testing of discs resulted in a decrease in cell viability of the each cement tested.