Article

The imgt/HLA database

Anthony Nolan Research Institute, Royal Free Hospital, Pond Street, Hampstead, London NW3 2QG, UK.
Nucleic Acids Research (Impact Factor: 9.11). 11/2010; 39(Database issue):D1171-6. DOI: 10.1093/nar/gkq998
Source: PubMed

ABSTRACT

It is 12 years since the IMGT/HLA database was first released, providing the HLA community with a searchable repository of
highly curated HLA sequences. The HLA complex is located within the 6p21.3 region of human chromosome 6 and contains more
than 220 genes of diverse function. Many of the genes encode proteins of the immune system and are highly polymorphic. The
naming of these HLA genes and alleles and their quality control is the responsibility of the WHO Nomenclature Committee for
Factors of the HLA System. Through the work of the HLA Informatics Group and in collaboration with the European Bioinformatics
Institute, we are able to provide public access to this data through the web site http://www.ebi.ac.uk/imgt/hla/. Regular updates to the web site ensure that new and confirmatory sequences are dispersed to the HLA community, and the wider
research and clinical communities.

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