Successful sulfonylurea treatment of a neonate with neonatal diabetes mellitus due to a new KCNJ11 mutation

Department of Neonatology, University Children's Hospital, Tiršova 10, Belgrade, Serbia.
Diabetes research and clinical practice (Impact Factor: 2.54). 11/2010; 91(1):e1-3. DOI: 10.1016/j.diabres.2010.09.027
Source: PubMed


Mutations in the KCNJ11 gene, which encodes the Kir6.2 subunit of the ATP-sensitive potassium channel, often result in neonatal diabetes. We describe a female neonate who is a heterozygous for a new missense mutation, V252L, in the KCNJ11 gene and who has been successfully transitioned from insulin to sulfonylurea therapy.

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