ArticlePDF AvailableLiterature Review

Abstract and Figures

The therapeutic benefits of argan oil consumption have been claimed by natives of Morocco and explorers for more than eight centuries. However, argan oil has remained unresearched for a long time. Traditionally, argan oil has been well known for its cardioprotective properties and it is also used in the treatment of skin infections. Argan oil is principally composed of mono-unsaturated (up to 80%) and saturated (up to 20%) fatty acids. As minor components, it contains polyphenols, tocopherols, sterols, squalene, and triterpene alcohols. Together with the mono-unsaturated fatty acids, these minor components are likely to be responsible for its beneficial effects. This review aims to present an overview of the known pharmacological properties of argan oil. Antiproliferative, antidiabetic, and cardiovascular-protective effects of argan oil have been particularly actively evaluated over the last 5 years in order to build on phytochemical studies that indicate the presence of large amounts of possibly pharmacologically active compounds. This review shows that a lack of clinical data constitutes a serious weakness in our knowledge about argan oil, therefore it is difficult to correlate the reported pharmacological activities to any potential clinical relevance.
Content may be subject to copyright.
Therapeutic potential of argan oil: a reviewjphp_11901669..1675
Hanae El Monfaloutia,b, Dom Guillaumea, Clément Denhezaand
Zoubida Charroufb
aUniversité de Reims Champagne Ardenne, Laboratoire de Chimie Thérapeutique, 51 Rue Cognacq Jay,
51100 Reims, France and bUniversité Mohammed V-Agdal, Laboratoire de Chimie des Plantes, Faculté des
Sciences, BP 1014, Rabat, Morocco
Abstract
Objectives The therapeutic benefits of argan oil consumption have been claimed by
natives of Morocco and explorers for more than eight centuries. However, argan oil has
remained unresearched for a long time. Traditionally, argan oil has been well known for its
cardioprotective properties and it is also used in the treatment of skin infections. Argan oil
is principally composed of mono-unsaturated (up to 80%) and saturated (up to 20%) fatty
acids. As minor components, it contains polyphenols, tocopherols, sterols, squalene, and
triterpene alcohols. Together with the mono-unsaturated fatty acids, these minor components
are likely to be responsible for its beneficial effects. This review aims to present an overview
of the known pharmacological properties of argan oil.
Key findings Antiproliferative, antidiabetic, and cardiovascular-protective effects of argan
oil have been particularly actively evaluated over the last 5 years in order to build on
phytochemical studies that indicate the presence of large amounts of possibly pharmaco-
logically active compounds.
Summary This review shows that a lack of clinical data constitutes a serious weakness in
our knowledge about argan oil, therefore it is difficult to correlate the reported pharmaco-
logical activities to any potential clinical relevance.
Keywords Argania spinosa; edible oil; fatty acid; food supplement; tocopherol
Introduction
‘Cold-pressed oils’ and ‘virgin oils’ are two terms that can be confusing. Clarification was
recently brought to this problem by Matthäus.[1] The term ‘cold-pressed oil’ can be used
when a careful, gentle mechanical extraction of the raw material without application of heat
is used. However, heat-treatment is allowed during preparation of the raw material and/or of
the oil after the pressing process.
Following this definition, edible argan oil is a cold-pressed oil. It is prepared by pressing
the slightly roasted kernels of the argan tree [Argania spinosa (L.) Skeels] fruit. A. spinosa
is only endemic in south-western Morocco, where it covers an area of 3200 square miles that
constitutes a unique biotope, named ‘the argan forest’. In Morocco, the argan forest has an
essential agro-economic function.[2] Because the argan tree is drought-resistant, it is also a
powerful weapon for slowing down desertification.[3]
Sustainable development of the argan forest was initiated 15 years ago but its success was
only recently ascertained.[4,5] The first step in this ambitious programme was the search for
argan tree products possessing an economic value.
Cell-wall polymers of plants constitute the functional matrix that controls plant growth,
development and interactions with biotic and abiotic environments. Some of these polymers
have a cosmetic or nutraceutical value. Cell-wall polymers of A. spinosa leaves and fruit
pulp include potentially valuable xyloglucans, galacturonans and pectins.[6–8] However, none
of these compounds have yet been commercially exploited. Early phytochemical studies led
to the identification of several saponins from A. spinosa.[9] The high saponin content of the
trees was more recently confirmed.[10–12] Some of these saponins appear to have promising
antiviral[13] or antioxidant[14] properties. Their introduction in cosmetic creams has also been
commercially investigated.[15] Other metabolites from A. spinosa also have potential value in
the cosmetic domain, and their industrial use is being actively investigated. In particular, its
press-cake – the residue that remains after pressing the kernels – is a rich source of valuable
proteins,[16] and its leaves contain high level of flavonoids (mainly quercetin and myricetin
Review
JPP 2010, 62: 1669–1675
© 2010 The Authors
JPP © 2010 Royal
Pharmaceutical Society of
Great Britain
Received February 26, 2010
Accepted August 10, 2010
DOI
10.1111/j.2042-7158.2010.01190.x
ISSN 0022-3573
Correspondence: Dom
Guillaume, Université de Reims
Champagne Ardenne,
Laboratoire de Chimie
Thérapeutique, 51 rue Cognacq
Jay, 51100 Reims, France.
E-mail:
dominique.guillaume@univ-reims.fr
1669
derivatives), which have potential uses in cosmetics.[17] The
use of A. spinosa triterpenes is also being commercially evalu-
ated.[18] Essential oils are also highly valuable derivatives, due
to their pharmacological properties.[19–21] Essential oils con-
tained in A. spinosa fruit pulp may also be of interest for use
as an insect repellent.[22]
However, argan oil is by far the most valuable product
derived from the argan tree. Its dietary and medicinal qualities
are responsible for argan oil’s important position in the oil
market. Today, not only is argan oil quoted as ‘the world’s
most expensive oil’but in 2009, it was ranked the number one
cosmetic ingredient by Pierce Mattei, an important public
relations firm working in the fashion and beauty area. For
years, argan forest dwellers have claimed that argan oil is
hepatoprotective and choleretic, that it prevents diabetes and
that it has anti-inflammatory properties. Edible argan oil is
therefore the basis of the ‘amazigh diet’.[23] As a cosmetic,
argan oil revitalises the skin, cures acne, hydrates dry skin,
makes hair shine and so on. This review presents an overview
of argan oil’s medicinal properties as presently understood.
Chemical Constituents and
Bioactive Compounds
Glycerides are the main chemical constituents of argan oil (up
to 99%). Triglycerides compose not less than 95% of this
fraction. The main fatty acids in these triglycerides are oleic
and linoleic acids (47 1% and 33 3%, respectively), and
two n-6 (omega-6) fatty acids.[24] There are also small amounts
of saturated fatty acids in the triglycerides of argan oil: stearic
acid (5.5 1.5%) and palmitic acid (13.5 1.5%).[24] For
comparison purposes, the fatty acid content of some common
and ‘less common’ oils[25,26] is reported in Table 1.
Minor components of argan oil include other organic
derivatives such as (poly)phenols. Phenolic concentrations are
very low,[27] but among those compounds unambiguously
identified are vanillic acid, syringic acid, ferulic acid, tyrosol,
catechol, resorcinol, (-)-epicatechin and (+)-catechin.[28–30]
The presence of caffeic acid and oleuropein has been
reported[31] but this finding has never been confirmed.
Squalene, carotenes, triterpene alcohols (butyrospermol, tiru-
callol, b-amyrine, lupeol, 24-methylene cycloartanol, citros-
tadienol and cycloeucalenol), sterols (spinasterol, schottenol,
stigma-8,22-dien-3b-ol (22E,24Z), stigmasta-7,24-28-
dien-3b-ol (24Z)), and a-, b-, g- and d-tocopherols (13%,
16%, 69% and 2%, respectively)[28,32] are other minor organic
components of argan oil. There are also traces of inorganic
elements (iron, copper, manganese and lead).[33]
The chemical composition of most of the edible vegetable
oils is responsible for their favourable pharmacological pro-
files.[34] The particularly beneficial and healthful properties of
argan oil have mainly been attributed to its specific polyphe-
nol, squalene and tocopherol content.[28]
Unsaturated fatty acids are involved in several metabolic
pathways, including chronic inflammation, a causative factor
in a variety of cancers.[35] Although fatty acids belonging to
the n-3 series are sometimes presented as the most efficient
cardioprotectors, n-6 fatty acids are also essential in the com-
position of an equilibrated lipid diet.[36] Indeed, oleic acid is
directly responsible for the reduction of blood pressure,
through regulation of membrane lipid structure[37] and inhibi-
tion of the activity of gelatinase A (MMP-2),[38] an enzyme
involved in cancer proliferation and Alzheimer’s disease.
Moreover, linoleic acid, the second major fatty acid of argan
oil, is the metabolic precursor of arachidonic acid and its
multiple bioactive eicosanoid derivatives.
Because of their free-radical scavenging and antioxidant
properties, phenolic compounds and tocopherols also dra-
matically contribute to the beneficial pharmacological prop-
erties of argan oil. g-Tocopherol is also known for its role in
the primary prevention of heart disease[39] and possibly pros-
tate cancer.[40]
Types of Oil
Traditional argan oil
The traditional process for argan oil extraction has already
been reported in detail several times[2,3,32] and therefore will
not be presented here. This is the type of oil that has been
prepared for centuries by Moroccan women on a family scale.
However, traditionally prepared argan oil chemical composi-
tion is poorly reproducible.[3] Such oil is generally of low
quality and has a short shelf-life (Table 2).[41] For a single
person, 2–2.5 l of oil are obtained from 100 kg of dry fruit
after 58 h of work.
Cold-pressed argan oil
To produce large quantities of high-quality argan oil,
women’s cooperatives have been started in south-western
Morocco.[2,42] In these cooperatives, argan oil is prepared by
mechanically cold-pressing argan kernels. Using this technol-
ogy, 4–6 l of oil can be obtained from 100 kg of dry fruit after
13 h of work by a single person.
Edible argan oil is prepared from roasted kernels, whereas
unroasted kernels are used in the production of cosmetic argan
oil (Table 2). The origin of the fruit and the processing method
Table 1 Percentage of oleic, linoleic, stearic and palmitic acid in common (corn, olive, soybean, sunflower and peanut) and less common (grape seed,
argan) oils
Fatty acid Corn oil Olive oil Soybean oil Sunflower oil Peanut oilaGrape seed oil Argan oil
Oleic 20–42.2 55–83 17.7–28 14–39.4 35–69 12–28 43–49.1
Linoleic 34–65.6 3.5–21 49.8–59 48.3–74 12–43 58–78 29.3–36
Stearic <3.3 <5 2–5.4 2.7–6.5 1–4.5 <3.3 4.3–7.2
Palmitic 8.6–16.5 7.5–20 8–13.5 5–7.6 8–14 8.6–16.5 11.5–15
aContains also behenic, arachidic and eicosenoic acids (1.5–4.5%, 1–2% and 0.7–1.7%, respectively).
1670 Journal of Pharmacy and Pharmacology 2010; 62: 1669–1675
used dramatically influence the quality of the argan oil pro-
duced.[43] Because of this, stringent preparation rules have
been implemented in the cooperatives. These include the use
of mechanical pressing in place of hand-pressing and
mechanical fruit peeling. Also, the use of goat-digested argan
nuts has been strictly outlawed, even though such a picking
method was never general practice, as has sometimes been
stated.[44] The polyphenol and tocopherol content of tradition-
ally extracted and cold-pressed argan oils is similar. Their
different shelf life is mainly due to the selection of the argan
nuts and the frequent use of water of poor bacteriological
quality during the traditional process.
Edible argan oil is also the major constituent of ‘Amlou’, a
highly nutritive preparation whose composition also includes
large quantities of crushed almonds and honey.
Cosmetic argan oil is directly used for skin application or
as a hair lotion. It does not have the hazelnut taste of edible
argan oil. Its content of volatile components is lower than
that of edible argan oil[45] and its shelf life is also shorter, the
latter extending up to 2 years, probably due to the formation
during roasting of Maillard compounds, which favour
preservation.[46]
Solvent-extracted argan oil
Industrially, cosmetic argan oil is prepared by solvent extrac-
tion of crushed argan kernels. No quality control is required
for argan nuts (Table 2). Solvent-extracted argan oil, which is
also sometimes flash distilled and deodorised, is used exclu-
sively in the composition of creams, shampoos and body
lotions. Preservatives are frequently added to compensate for
the naturally protective agents lost during extraction and/or
distillation (tocopherols, polyphenols etc.).
Human Health and Argan
Oil Consumption
Argan oil has been used as a food and as a food ingredient,
and has been applied to the skin for centuries, therefore its
acute and chronic toxicity is assumed to be nil, particularly
when orally administered at ordinary doses. Initially, argan
oil’s pharmacological properties have simply been deduced
by consideration of the properties of its constituents, which
have been isolated and pharmacologically evaluated, often in
simple models. The chemical composition of argan oil
has already been reviewed in detail,[32] and this aspect will
therefore not be discussed here. Recently, scientific evaluation
of the traditionally claimed benefits of argan oil consumption
has begun, using animal models or cohort or clinical studies.
These studies (Table 3) were aimed at determining if argan oil
has only nutritional properties or if it can be said to also
possess pharmacological properties.[65] Nevertheless, the
general benefits indicated by some primary results have
already triggered the preparation of argan oil-based emulsions
for parenteral nutrition.[47]
Table 2 Differences between the four argan oil types
Traditional oil Cold-pressed edible oil Cold-pressed cosmetic oil Industrial cosmetic oil
Material Uncontrolled fruit,
roasted kernels
Hand-picked fruit,
roasted kernels
Hand-picked fruit,
unroasted kernels
Uncontrolled fruit,
unroasted kernels
Process Hand malaxing Press Press Solvent
Preservation One to two weeks Several months Up to one month Several months
Colour Yellow to brown Copper-like Gold-like No colour
Taste Not reproducible Hazelnut like Bitter Not suitable as food
Quality Low Very high Very high Very high
Moisture Variable Low Some amount None
Antioxidants Variable High High None
Table 3 Key papers on the pharmacology of argan oil and their scien-
tific findings
Reference Keys papers and their scientific findings
Khallouki et al.[28] Chemical composition of argan oil indicates its
potential interest in preventing cancer
Bensouada[47] Emulsion containing argan oil can be used for
parenteral nutrition
Berrougui et al.[48] Argan oil phenolic extract inhibits low-density
lipoprotein oxidation and has hypolipemiant
properties
Berrougui et al.[49] Argan oil has hypolipidemic and
hypocholesterolemic effects in rats
Drissi et al.[50] Argan oil has hypolipemiant and antioxidant
properties
Derouiche et al.[51] Argan oil has an hypolipemiant effect in man
Berrougui et al.[52] Argan oil lowers blood pressure in rats
Adlouni et al.[53] Argan oil prevents obesity risk
Cherki et al.[54] Argan oil presents an antiatherogenic effect in
humans
Mekhfi et al.[55] Argan oil inhibits platelet aggregation but has no
influence on bleeding time
Bennani et al.[56] Argan oil polyphenols and sterols have an
antiproliferative effect on human prostate cancer
cell lines
Bennani et al.[57] Argan oil polyphenols have an antiproliferative
effect on human prostate cancer cell lines
Drissi et al.[58] Argan oil tocopherols have an antiproliferative
effect on human prostate cancer cell lines
Samane et al.[59] Argan oil has a potential interest as an antidiabetic
Bnouham et al.[60] Antidiabetic activity of argan oil is confirmed
Samane et al.[61] Argan oil is less efficient than fish oil to treat
diabetes
Derouiche et al.[62] Argan oil has no impact on thyroid hormone
profile
Benzaria et al.[63] Argan oil does not influence immune system
Astier et al.[64] Argan oil triggers allergic reaction
Therapeutic potential of argan oil Hanae El Monfalouti et al.1671
Cancer chemoprotective effects
Because argan and olive oils share a similar composition, the
cancer chemoprotective effect attributed to olive oil has also
been attributed to argan oil.[28] Argan oil’s high levels of
g-tocopherol – by far the most potent antioxidant of the toco-
pherols – and its high squalene content have even led to a
suggestion that its chemoprotective effect may even be
greater.[66]
Antioxidants present in argan oil[67] are believed to
prevent or delay the onset of reactive oxygen species after
lipid peroxidation observed in rats or human plasma.[48,49]
Specific investigations on prostatic cells have shown that, in
vitro, argan oil polyphenols and sterols have cytotoxic prop-
erties and exert an inhibitory effect on the proliferation of
hormone-independent (DU145 and PC3) as well as of
hormone-dependent (LNCaP) prostate cancer cell lines. The
relative cytotoxic activity of argan oil polyphenols measured
by means of the MTT assay indicates IC50 values of 75, 100
and 50 mg/ml for the DU145, LNCaP and PC3 cell lines,
respectively.[56] For argan oil sterols, the IC50 values are 25,
75 and 70 mg/ml for the DU145, LNCaP and PC3 cell lines,
respectively.[56]
In respect of cell proliferation, the calculated polyphenol
concentrations inhibiting cell growth by 50% (GI50) at 24 h,
in comparison with 2-methoxyestradiol, were 75, 100 and
50 mg/ml for the DU145, LNCaP and PC3 cell lines, respec-
tively.[56] The sterol GI50s, in the same conditions, were 25,
75 and 70 mg/ml for the DU145, LNCaP and PC3 cell lines,
respectively.[56] On the canine prostate cancer epithelial cell
line (DPC-1), argan oil polyphenols showed a dose-
dependent antiproliferative effect at an IC50 of 10 mg/ml.[57]
However, only a weak antiproliferative effect was observed
when argan oil polyphenols were evaluated on the SV40-
immortalised human prostate epithelial cell line PNT1A.[57]
A cell cycle arrest mediated by up-regulation of the P27
cell cycle regulatory protein may explain the observed physi-
ological activity of the tocopherols.[58] Large-scale epidemio-
logic studies using a g-tocopherol-enriched diet have
confirmed the beneficial effects of g-tocopherol on prostate
cancer prevention in humans.[40] Consequently, these results
have encouraged the study of the antiproliferative effects of
the polyphenol and sterol fractions of argan oil.
Inhibition of several enzymes, including ornithin decar-
boxylase, an enzyme highly expressed in prostate cancer, and
NO synthase, or of the autophosphorylation of the epithelial
growth factor receptor could explain the observed anti-
proliferative activity.[68] In an independent study, the antipro-
liferative effect of the squalene and polyphenol-rich
unsaponifiable extract of argan oil on two cell lines (human
HT-1080 fibrosarcoma and the transformed and invasive
MSV-MDCK-inv cells) was clearly evidenced.[59] Using
hepatoma tissue culture cells, it was shown that the squalene-
and polyphenol-rich extract of argan oil reduces the ability of
extracellular signal-regulated kinases 1 and 2 (ERK1/2) to
respond to increasing doses of insulin.[59] Conversely, the
response of the serine/threonine kinase (Akt), whose major
function is to promote growth-factor-mediated cell survival
and to block apoptosis response, remained undisturbed.
Further in-vitro studies showed that argan oil polyphenols
specifically interrupt the insulin-signalling cascades at the
MEK1/2-ERK1/2 interface.[59]
Prevention of obesity and adverse
cardiovascular outcomes
Hypercholesterolemia and platelet hyperactivity are associ-
ated with an increased risk of adverse cardiovascular out-
comes (coronary artery disease, hypertension etc.). Phenolic
compounds, phytosterols and tocopherols are well known as
efficient hypocholesterolemic agents. Not surprisingly, argan
oil’s phenolic fraction prevents low-density lipoprotein (LDL)
oxidation in isolated human plasma.[48] Phenolic compounds
also enhance reverse cholesterol transport by increasing high-
density lipoprotein (HDL) lipid-bilayer fluidity.[48] The pres-
ence of these derivatives is therefore commonly used to
explain the anti-atherogenic potential of argan oil.[48]
Initially evidenced on rats,[49,52] the hypolipidemic and
hypocholesterolemic potency of argan oil in humans has been
demonstrated by mean of a cohort study on 60 men.[54] The
effect was shown to be due to a paraoxonase-related improve-
ment of the plasma oxidative status. The anti-atherogenic
properties of argan oil have been evidenced by significant
increases in paraoxonase activity and a decrease in lipoper-
oxide and conjugated diene formation.[54] Other complex path-
ways, initially resulting from an intracellular accumulation of
squalene and ultimately triggering the liver X receptors,[69]
may also explain argan oil’s anti-atherogenic effects. A series
of nutritional interventions has also shown that argan oil
induces a lowering of LDL cholesterol and has antioxidant
properties, as shown by a cohort study of 96 persons.[50] Here,
subjects consuming argan oil on a regular basis presented
significantly lower levels of plasma LDL cholesterol and lipo-
protein (a) and lower concentrations of plasma lipoperox-
ides.[50] Argan oil also increases HDL cholesterol levels and
lowers triglyceride levels in men,[51] therefore, and as might be
expected, regular argan oil consumption has the potential to
prevent obesity.[53]
Argan oil also inhibits platelet aggregation without causing
either prolongation of bleeding time or a change in platelet
levels.[55] In vitro, an inhibition of thrombin- or epinephrin-
induced aggregation up to 50% was obtained at a dose of 0.5%
of argan oil.[55] When rats were orally treated for 4 weeks with
10 ml/kg/day of argan oil, the thrombin-induced aggregation
of isolated platelets was significantly inhibited (36%).[55]
However, bleeding time remained unchanged,[55] therefore
argan oil may act on the attachment of fibrinogen to GIIb/IIIa
platelet receptor without affecting the adhesiveness of plate-
lets to the vascular endothelium.[55] Together, these studies
have led to argan oil consumption being recommended for the
reduction of cardiovasuclar risk and the prevention of obesity,
as has been traditionally claimed.[70]
Influence on thyroid hormone profile
Thyroid hormones and fatty acid metabolism are closely
related. Unsaturated fatty acids have been shown to possibly
prevent hypothyroidism.[71] The thyroidic activity of argan oil
has been evaluated in a cohort study performed on 149 euthy-
roidic volunteers consuming non-iodised salt by measuring
plasmatic concentrations of free tri-iodothyronine (FT3),
1672 Journal of Pharmacy and Pharmacology 2010; 62: 1669–1675
tetra-iodothyronine (FT4) and thyroid stimulating hormone.
This study evidenced that no activity on hypothyroidism
could be expected from argan oil dietary supplementation.[62]
Antidiabetic activity
The cardiovascular protective and antidiabetic effects of argan
oil are the most longstanding claimed pharmacological effects
of argan oil.[3] So far, however, the only scientific demonstra-
tion of a possible antidiabetic activity has been in rats.[60] Oral
glucose test tolerance was performed on healthy or
streptozotocin-induced diabetic rats. Intraperitoneal adminis-
tration of argan oil (2.5 ml/kg) 30 min before oral glucose
loading (1 g/kg) induced a significant glycemia reduction that
lasted for 3 h.[60] Argan oil also significantly reduced the
amount of absorbed glucose in perfused jejunum segment.[60]
Samane et al. compared the metabolic response of rats to a
free-access high-fat/high-sucrose diet in which 6% of the fat
was replaced either by argan oil or fish oil. Intake of argan and
fish oil resulted in the restoration of insulin signalling in fat and
liver but fish oil also restored systemic insulin sensitivity.[61]
Influence on the immune system
Recent biochemical studies have shown that fatty acids may
modify immune responses.[72] Indeed, lymphocyte prolifera-
tion, lymphocyte-derived cytokine production and cell-
mediated immunity can all be influenced by dietary lipids.
The effect of dietary argan oil on the immune system has been
evaluated on rats.[63] These studies concluded that argan and
olive oil’s effects on immune cells are similar, and that argan
oil has no marked effects on immune cell function.[63]
Anaphylaxis properties
The first, and so far unique, case of an allergy to argan oil has
recently been presented.[64] Allergen was characterised as a
10 kDa protein, probably belonging to the family of oleosins
that is also encountered in peanut and sesame.
Argan Oil Versus Other Edible Oils
The quality of an edible oil can be reflected in different
factors. Among these, the most important are its sensory
quality, its nutritional value and its pharmacological effect. If
the sensory quality is important to get consumer acceptance
and hence to occupy a reasonable market share, nutritional
and pharmacological qualities are essential from a dietary
standpoint.
In evaluating the nutritional quality of oil, fatty acid com-
position occupies a special place. More particularly, (poly)un-
saturated fatty acids are essential nutrients, for they are the
biological precursors of leukotrienes and prostaglandins, two
types of compounds acting as hormone-like cell messengers.
However, the simple presence of a high amount of linoleic
acid does not necessary imply an oil of high nutritional value,
as reported for grape seed oil.[73]
Olive oil is oleic acid-rich (Table 1). It is a globally used
edible oil that is considered to be a key ingredient in the
Mediterranean diet. Hence, its nutritional quality is recogn-
ised as high,[74] as are its unique biological properties.[75]
Olive and argan oil contain high levels of oleic acid, with
linoleic acid as the second major unsaturated fatty acid of
each oil. The saturated fatty acids of both oils are palmitic
and stearic acids, therefore the general nutritional qualities
of olive and argan oils are likely to be identical. If only
average values are considered, olive oil contains statistically
higher values of monounsaturated fatty acid than argan oil.
Argan oil is therefore nutritionally close to peanut oil, even
though the latter contains small amounts of arachidic and
behenic acids, saturated fatty acids that are not found in
argan oil.[26] Nevertheless, this type of classification relies
only on statistical analysis. The major difference between
argan and olive oil is the large chemical variability tolerated
for olive oil. Indeed, olive oil is produced in the whole
Mediterranean basin and, because of its multiple geographic
origins, olive oil fatty acid composition varies greatly. For
example, its composition in linoleic acid can be either 3.5 or
21% and its level of oleic acid can be up to 83% but can be
as low as 55%. Since consumers are not necessarily aware
of the geographical origin of the olive oil they purchase,
they cannot be certain of the precise nutritional value of any
particular olive oil. In contrast, argan oil fatty acid compo-
sition is much more homogenous and, consequently, its
nutritional value is less variable.
Variation in the geographic origin of edible oils also dra-
matically affects the proportions of the minor oil components.
These oils also contribute to the pharmacological quality of
the oil. Several of olive oil’s minor components (polyphenols,
sterols, tocopherols etc.) have been presented as responsible
for the oil’s pharmacological properties,[75] but large varia-
tions have also been observed in terms of concentration, sug-
gesting that not all olive oils have the same pharmacological
potential.[76] Again, the minor component profile of argan oil
has little variation and is likely to be responsible for a more
reproducible pharmacological profile.
Argan Oil as a Food Supplement
Argan oil’s specific taste and its claimed pharmacological
properties are at the origin of the culinary and medicinal
interest directed at this oil in the last 10 years. The benefits for
the elderly of a long-term diet rich in argan oil are currently
being evaluated. Even slightly encouraging results could
rapidly lead to argan oil gaining a place in the lucrative food
supplement field.
However, quality matters could prevent this happening.
Because of the elevated price of argan oil and since there are
many other vegetable oils on the market, adulteration of argan
oil is a risk. To prevent this fraudulent behaviour, simple
analytical methods have been designed to unambiguously dis-
tinguish argan oil from other oils, based on the presence of a
marker in low quantity oils.[77] Argan oil’s recently granted
status as a product of protected geographic indication is also
going to be an efficient means to control its sensory, nutri-
tional and pharmacological quality. Processing parameters as
simple as argan kernel storage conditions influence oil quality
and levels of minor components,[78] therefore each processing
parameter is currently being investigated. Optimum param-
eters will become mandatory after inclusion in the geographic
indication file in order to maintain argan oil’s chemical and
pharmacological quality.
Therapeutic potential of argan oil Hanae El Monfalouti et al.1673
Conclusions
This review shows that while the chemistry and a few phar-
macological aspects of argan oil have been studied, there are
still no strong clinical data available that provide evidence of
the efficacy of argan oil in humans. That argan oil constituents
have pharmacological properties in vitro is not sufficient to
ascertain the clinical potential of whole argan oil. More
studies are necessary to determine its impact on human health.
Considering the elevated price of argan oil, these studies
should be aimed at demonstrating the intrinsic as well as
relative efficacy of argan oil compared to other oils. Interest-
ingly, the position of argan oil as a natural product with strong
consumer expectations resulting from traditional claims of
activity that are insufficiently supported by scientific proof is
shared by several other plant extracts or products.[79,80] Such a
trend is likely to continue in view of the strong current
demand for food supplements. This demand justifies pharma-
cological studies on these products.
Declarations
Conflict of interest
The Author(s) declare(s) that they have no conflicts of interest
to disclose.
Funding
This review received no specific grant from any funding
agency in the public, commercial or not-for-profit sectors.
References
1. Matthäus B, Spener F. What we known and what we should
know about virgin oils-A general introduction. Eur J Lipid Sci
Technol 2008; 110: 597–601.
2. Charrouf Z, Guillaume D. The rebirth of the argan tree or how to
give a future to Amazigh women. In: Harpelle RL, Muirhead B,
eds. Long-Term Solutions for a Short-Term World: Canada and
Research Development. Waterloo: WLU Press, 2010, ISBN 13:
978-1-55458-223-5.
3. Charrouf Z et al. [The argan tree, an asset for Morocco]. Biofutur
2002; 220: 54–57 [in French].
4. Charrouf Z et al. Enhancing the value of argan oil is the best
mean to sustain the argan grove economy and biodiversity, so far.
Oléag Corps Gras Lipides 2008; 15: 269–271.
5. Charrouf Z, Guillaume D. Sustainable development in Northern
Africa: the argan forest case. Sustainability 2009; 1: 1012–1022.
6. Aboughe-Angone S et al. Cell wall carbohydrates from fruit
pulp of Argania spinosa: structural analysis of pectin and xylo-
glucan polysaccharides. Carbohydr Res 2008; 343: 67–72.
7. Habibi Y et al. Isolation and charaterization of xylans from seed
pericarp of Argania spinosa.Carbohydr Res 2006; 340: 1431–
1436.
8. Ray B et al. Structural investigation of hemicellulosic polysac-
charides from Argania spinosa: characterization of a novel xylo-
glucan motif. Carbohydr Res 2004; 339: 201–208.
9. Charrouf Z et al. Triterpenoid saponins from Argania spinosa.
Phytochemistry 1992; 31: 2079–2086.
10. Oulad-Ali A et al. Structure elucidation of three triterpene gly-
cosides from the trunk of Argania spinosa.J Nat Prod 1996; 59:
193–195.
11. Guillaume D, Charrouf Z. [Saponines et métabolites secondaires
de l’arganier (Argania spinosa): état des connaissances]. Cah
Agric 2005; 15: 509–516 [in French].
12. El Fakhar N et al. New triterpenoid saponins from Argania
spinosa.J Nat Med 2007; 61: 375–380.
13. Gosse B et al. Antiviral saponins from Tieghemella heckelii.J
Nat Prod 2002; 65: 1942–1944.
14. Amzal H et al. Protective effect of saponins from Argania
spinosa against free radical-induced oxidative haemolysis. Fitot-
erapia 2008; 79: 337–344.
15. Henry F et al. Use of an extract from the plant Argania spinosa.
Patent US 2006/0083794 A1, 2006.
16. Pauly G et al. Cosmetic and/or dermopharmaceutical prepara-
tions containing native proteins from the plant Arganaia spinosa.
Patent US 2004/42996 A1, 2004.
17. Pauly G et al. Cosmetic and/or dermopharmaceutical prepara-
tions containing leaf extract of the plant Argania spinosa. Patent
US 7,105,184 B2, 2006.
18. Henry F et al. Composition containing a plant extract and
process for producing same. Patent US 2007/0281047 A1, 2007.
19. De Menezes IAC et al. Cardiovasular effects induced by Cym-
bopogon winterianus essential oil in rats: involvement of
calcium channels and vagal pathway. J Pharm Pharmacol 2010;
62: 215–221.
20. Koch C et al. Efficacy of anise oil, dwarf-pine oil and chamo-
mille oil against thymidine-kinase-positive and thymidine-
kinase-negative herpesviruses. J Pharm Pharmacol 2008; 60:
1545–1550.
21. Sousa OV et al. Antinociceptive and anti-inflammatory effects of
the essential oil from Eremanthus erythropappus leaves. J
Pharm Pharmacol 2008; 60: 771–777.
22. Harhar H et al. Composition of the essential oil of Argania
spinosa (Sapotaceae) fruit pulp. Nat Prod Commun 2010; 5:
935–936.
23. Charrouf Z, Guillaume D. Should the amazigh diet (regular and
moderate argan-oil consumption) have a beneficial impact on
human health? Crit Rev Food Sci Nutr 2010; 50: 473–477.
24. Charrouf Z, Guillaume D. Ethnoeconomical, ethnomedical and
phytochemical study of Argania spinosa (L.) Skeels. J Ethno-
pharmacol 1999; 67: 7–14.
25. Food and Agriculture Organization of the United Nations/World
Health Organization, Joint FAO/WHO Food Standards Pro-
gramme: Codex Alimentarius Commission. In: Codex Alimenta-
rius Volume 8, Fats, Oils and Related Products, 2nd edn. Codex
Standard for named Vegetable Oils Codex-STAN 210 (Amended
2003, 2005). Rome, WHO, 1993: 1–16.
26. Dubois V et al. Fatty acid profiles of 80 vegetable oils with
regards to their nutritional potential. Eur J Lipid Sci Technol
2007; 109: 710–732.
27. Mouhajir F et al. Phenolics in moroccan medicinal plant species
as studied by electron spin resonance spectroscopy. Pharm Biol
2001; 39: 391–398.
28. Khallouki F et al. Consumption of argan oil (Morocco) with its
unique profile of fatty acids, tocopherols, squalene, sterols and
phenolic compounds should confer valuable cancer chemopre-
ventive effects. Eur J Cancer Prev 2003; 12: 67–75.
29. Rojas LB et al. Colorimetric evaluation of phenolic content and
GC-MS characterization of phenolic composition of alimentary
and cosmetic argan oil and press cake. J Agric Food Chem 2005;
53: 9122–9127.
30. Charrouf Z, Guillaume D. Phenols and polyphenols from
Argania spinosa.Am J Food Technol 2007; 2: 679–683.
31. Chimi H et al. Etude de la fraction phénolique des huiles d’olive
vierge et d’argan du Maroc. Actes Inst Agron Vét 1998; 8: 17–
21.
1674 Journal of Pharmacy and Pharmacology 2010; 62: 1669–1675
32. Charrouf Z, Guillaume D. Argan oil: occurrence, composition
and impact on human health. Eur J Lipid Sci 2008; 110: 632–
636.
33. Marfil R et al. Metal content and physicochemical parameters
used as quality criteria in virgin argan oil: influence of the extrac-
tion method. J Agric Food Chem 2008; 56: 7279–7284.
34. Foster R et al. Culinary oils and their health effects. Nutr Bull
2009; 34: 4–47.
35. Blouin JM et al. [Effet des acides gras sur l’inflammation et le
cancer]. Oléag Corps Gras Lipides 2006; 13: 331–336 [in
French].
36. Russo GL. Dietary n-6 and n-3 polyunsaturated fatty acids: from
biochemistry to clinical implications in cardiovascular preven-
tion. Biochem Pharmacol 2009; 77: 937–946.
37. Terés S et al. Oleic acid content is responsible for the reduction
in blood pressure induced by olive oil. Proc Natl Acad Soc USA
2008; 105: 13811–13816.
38. Emonard H et al. Inhibition of gelatinase A by oleic acid. Ann NY
Acad Sci 1999; 878: 647–649.
39. Dietrich M et al. Does g-tocopherol play a role in primary pre-
vention of heart disease and cancer? A review. J Am Coll Nutr
2006; 25: 292–299.
40. Wright ME et al. Supplemental and dietary vitamin E intakes
and risk of prostate cancer in a large prospective study. Cancer
Epidemiol Biomarkers Prev 2007; 16: 1128–1135.
41. Matthäus B et al. Effect of processing on the quality of edible
argan oil. Food chem 2010; 120: 426–432.
42. Charrouf Z, Guillaume D. Argan oil, functional food, and the
sustainable development of the argan forest. Nat Prod Commun
2008; 3: 283–288.
43. Hilali M et al. Influence of origin and extraction method on
argan oil physico-chemical characteristics and composition. J
Agric Food Chem 2005; 53: 2081–2087.
44. Marcone MF. Characterization of the edible bird’s nest the
‘caviar of the east’. Food Res Internat 2005; 38: 1125–1134.
45. Charrouf Z et al. Influence of roasting and seed collection on
argan oil odorant composition. Nat Prod Commun 2006; 1: 399–
404.
46. Gharby S et al. Oxidative stability of edible argan oil: a two
year-study. LWT-Food Sci Technol 2010 (in press) doi:10.1016/
j.lwt.2010.07.003.
47. Bensouada Y. Formulation of argan-oil based lipid emulsion for
parenteral nutrition. Patent WO/2008/002116, 2008.
48. Berrougui H et al. Phenolic-extract from argan oil (Argania
spinosa L.) inhibits human low-density lipoprotein (LDL) oxi-
dation and enhances cholesterol efflux from THP-1 macroph-
ages. Atherosclerosis 2006; 184: 389–396.
49. Berrougui H et al. Hypolipidemic and hypocholesterolemic
effects of argan oil (Argania spinosa L.) in Meriones shawi rats.
J Ethnopharmacol 2003; 89: 15–18.
50. Drissi A et al. Evidence of hypolipemiant and antioxidant prop-
erties of argan oil derived from the argan tree (Argania spinosa).
Clin Nutr 2004; 23: 1159–1166.
51. Derouiche A et al. Nutritional intervention study with argan oil
in man: effects on lipids and apolipoproteins. Ann Nutr Metab
2005; 49: 196–201.
52. Berrougui H et al. Argan (Argania spinosa) oil lowers blood
pressure and improves endothelial dysfunction in spontaneously
hypertensive rats. Br J Nutr 2004; 92: 921–929.
53. Adlouni A et al. The nutritional benefits of argan oil in obesity
risk prevention. Atheroscler Suppl 2008; 9: 137–138.
54. Cherki M et al. Consumption of argan oil may have an anti-
atherogenic effect by improving paraoxonase activities and anti-
oxidant status: intervention study in healthy men. Nutr Metab
Cardiovasc Dis 2005; 15: 352–360.
55. Mekhfi H et al. Effect of argan oil on platelet aggregation and
bleeding time: a beneficial nutritional property. J Compl Integr
Med 2008; 5: 18.
56. Bennani H et al. Antiproliferative effect of polyphenols and
sterols of virgin argan oil on human prostate cancer cell lines.
Cancer Detect Prev 2007; 31: 64–69.
57. Bennani H et al. [Impact of argan oil on prostate cancer antipro-
liferative effect: study of polyphenols]. Rev Franco Lab 2009;
416: 23–26 [in French].
58. Drissi A et al. Tocopherols and saponins derived from Argania
spinosa exert an antiproliferative effect on human prostate
cancer. Cancer Invest 2006; 24: 588–592.
59. Samane S et al. Insulin-sensitizing and anti-proliferative effects
of Argania spinosa seed extracts. Evid-based Compl Alt Med
2006; 3: 317–327.
60. Bnouham M et al. Antidiabetic activity assessment of Argania
spinosa Oil. J Complement Integr Med 2008; 5: 32.
61. Samane S et al. Fish oil and argan oil intake differently modulate
insulin resistance and glucose intolerance in a rat model of
dietary-induced obesity. Metabolism 2009; 58: 909–919.
62. Derouiche A et al. Hormones thyroïdiennes et bilan lipidique de
deux populations du sud marocain consommatrices de l’huile
d’argan et du sel non iodé. Biol Santé 2005; 5: 185–192.
63. Benzaria A et al. Effect of dietary argan oil on fatty acid com-
position, proliferation, and phospholipase D activity of rat thy-
mocytes. Nutrition 2006; 22: 628–637.
64. Astier C et al. Anaphylaxis to argan oil. Allergy 2010; 65: 662–
663.
65. Adlouni A. [Argan oil: from nutrition to health]. Phytothérapie
2010; 8: 8–97 [in French].
66. Hübner J, Micke O. [Extra-european phytotherapeutics in
oncology-part 1]. Onkologe 2009; 15: 302–310. [in German].
67. Khallouki F et al. Thermal stability and long-chain fatty acid
positional distribution on glycerol of argan oil. Food Chem 2008;
110: 57–61.
68. Bennani H. Quel impact de l’huile d’argan sur le cancer de la
prostate? Technol Lab 2007; 6: 8–10.
69. Joseph SB et al. Synthetic LXR ligand inhibits the development
of atherosclerosis in mice. Proc Natl Acad Sci USA 2002; 99:
7604–7609.
70. Cherki M et al. Argan oil: which benefits on cardiovascular
diseases? Pharmacol Res 2006; 54: 1–5.
71. Makino M et al. Effect of eicosapentaenoic acid ethyl ester on
hypothyroid function. J Endocrinol 2001; 171: 259–265.
72. Yaqqob P. Fatty acids and the immune system: from basic
science to clinical applications. Proc Nutr Soc 2004; 63: 89–104.
73. Matthäus B. Virgin grape seed oil: is it really a nutritional high-
light? Eur J Lipid Sci Technol 2008; 110: 645–650.
74. Garcia-Gonzalez DL et al. Virgin olive oil – chemical implica-
tions on quality and health. Eur J Lipid Sci Technol 2008; 110:
602–607.
75. Pauwels EKJ, Covas MI. The Mediterranean diet, Part 1: the
anticancer effect of olive oil. Drugs Future 2009; 34: 307–313.
76. Medina E et al. Comparison of the concentrations of phenolic
compounds in olive oils and other plant oils: correlation with
antimicrobial activity. J Agric Food Chem 2006; 54: 4954–4961.
77. Hilali M et al. Detection of argan oil adulteration using campes-
terol GC-analysis. J Am Oil Chem Soc 2007; 84: 761–764.
78. Harhar H et al. Effect of argan kernel storage conditions on argan
oil quality. Eur J Lipid Sci Technol 2010 112: 915–920.
79. Obolskiy D et al.Garcinia mangostana L.: a phytochemical and
pharmacological review. Phytother Res 2009; 23: 1047–1065.
80. Napimoga NH et al. Scientific evidence for Mikania laevigata
and Mikania glomerata as a pharmaocological tool. J Pharm
Pharmacol 2010; 62: 809–820.
Therapeutic potential of argan oil Hanae El Monfalouti et al.1675
... Research has shown the effectiveness of natural remedies, such as natural oils, plant extracts and essential oils, in resolving this problem. For example, argan oil, the subject of our study, is renowned for its beneficial properties as an antioxidant (Adlouni, 2010;El Abbassi et al., 2014;El Monfalouti et al., 2010;Gharby et al., 2011), anticancer (Bennani et al., 2007), anti-inflammatory (Kamal et al., 2020;Lin et al., 2017;Menni et al., 2020), etc. That's why I was interested in the effect of argan oil and its constituents on the alcohol metabolism process, which can generally be carried out by three organs: the lungs, by the kidneys, but also by the liver, which plays a predominant role and eliminates alcohol through two key reactions. ...
... (Bahbiti et al., 2018), Table 1, and the choice of the argan oil was based on the beneficial effects of the latter on the disorders caused by alcohol. (Adlouni, 2010;Berrada et al., 2000;Drissi et al., 2004;El Monfalouti et al., 2010;El Mostafi et al., 2020;Hicham et al., 2018) ...
... Furthermore, the antioxidant properties of argan oil mitigate oxidative stress, protecting against mucosal damage and maintaining the integrity of the gut barrier, which is essential in preventing inflammatory responses triggered by microbial dysbiosis [72,73]. The ability of argan oil to modulate the microbiota and reduce inflammation makes it a potential therapeutic agent for managing IBD [74]. Personalized treatment plans that incorporate argan oil could restore a healthy microbiota balance and improve disease outcomes. ...
Article
Full-text available
Argan oil, rich in unsaturated fatty acids and polyphenols, exerts beneficial effects on both the intestinal and skin microbiotas. In the gut, it promotes the growth of beneficial bacteria, such as lactobacilli, while reducing pathogenic bacteria, due to its anti-inflammatory properties that help maintain microbial balance. Additionally, it improves the integrity of the intestinal mucosa, reducing the risk of dysbiosis. On the skin, argan oil hydrates and balances the lipid environment, creating a favorable setting for beneficial microorganisms, while also possessing antimicrobial and anti-inflammatory properties that soothe conditions like eczema and acne. Thus, argan oil is valuable for overall health, supporting digestion and skin health. The objective of this review is to provide a summary of the benefits of argan oil for alternative and complementary medicine. An exhaustive search of the literature was carried out using targeted keywords. A set of 83 articles were selected and analyzed. As the mechanisms of action of argan oil are not completely understood, this work highlighted the benefits of this oil by analyzing its nutritional properties and its beneficial effects on the intestinal and skin microbiotas. Indeed, argan oil is valuable for overall health.
... Argan oil nutritional and cosmetic properties are attributed to its elevated content in unsaturated fatty acids and antioxidants 2,7 . Both types of compounds are known to be impacted by deodorization 45,46 . ...
Article
Full-text available
Subquality argan kernels are 30% cheaper than the regular kernels mandatory used to prepare edible argan oil. The use of these argan kernels for the preparation of argan oil intended to be a cosmetic ingredient, after bleaching and deodorization, is therefore particularly economically appealing. The oxidative stability of Argan oil prepared from subquality kernels is unknown. It was evaluated over a period of storage of 12 weeks at 60 °C, then compared with that of argan oil stored under the same conditions and originating from the same initial batch, but which had subsequently been simply bleached and deodorized (physical refining). Physical refining led to an increase in initial oil quality due the loss of free fatty acids (up to 30% for refined argan oil), primary and secondary oxidation products but also to a dramatic decrease of the oxidative stability of argan oil caused by the loss of tocopherols, witnessed by the up to 94% loss after 12 weeks under accelerated storage conditions. As a conclusion, the oxidative stability of argan oil prepared from subquality argan kernels remains difficult to be adequately and efficiently evaluated since the initial quality of the argan kernels is the subject of great variations.
... Cosmetic Application: Argane oil is also used in cosmetic products for its therapeutic potential [16,32,33], serving as a moisturizing oil for the face, hands, and feet. In addition to these functions and uses, the Argane stands play a crucial role in sustaining the livelihoods of rural communities, helping to alleviate rural migration pressures. ...
Article
Full-text available
This comprehensive review explores the ecological significance of the Argane stands (Argania spinosa) in southwestern Morocco and the pivotal role of remote sensing technology in monitoring forest ecosystems. Argane stands, known for their resilience in semi-arid and arid conditions, serve as a keystone species, preventing soil erosion, maintaining ecological balance, and providing habitat and sustenance to diverse wildlife species. Additionally, they produce an extremely valuable Argane oil, offering economic opportunities and cultural significance to local communities. Remote sensing tools, including satellite imagery, LiDAR, drones, radar, and GPS precision, have revolutionized our capacity to remotely gather data on forest health, cover, and responses to environmental changes. These technologies provide precise insights into canopy structure, density, and individual tree health, enabling assessments of Argane stand populations and detection of abiotic stresses, biodiversity, and conservation evaluations. Furthermore, remote sensing plays a crucial role in monitoring vegetation health, productivity, and drought stress, contributing to sustainable land management practices. This review underscores the transformative impact of remote sensing in safeguarding forest ecosystems, particularly the Argane forest stands, and highlights its potential for continued advancements in ecological research and conservation efforts.
... Among Moroccan local products, Amlou is a traditional Moroccan culinary specialty from the Souss region, and one of the country's most prized local products [16]. It's a highly nutritive spread preparation made from three ingredients namely; Argan oil, roasted sweet almonds, and honey [17]. 100 g of Amlou provides around 690 kcals, 8.7 g of protein, 67 g of fat, 23 g of carbohydrates, 111 mg of calcium, and 108 mg of magnesium [18]. ...
Article
Full-text available
This study explores novel applications of combining natural products by integrating Ziziphus lotus L. (Z. lotus), honey, and argan oil to create a product similar to traditional Moroccan Amlou (a mixture of almonds, honey, and argan oil). Five formulations were developed with varying percentages of these three ingredients, alongside two formulations of traditional Amlou. The nutritional value, mineral composition, fatty acid profile, bioactive compounds, and antioxidant activities of the products were analyzed using standard analytical methods such as gas chromatography and spectrophotometry. Additionally, sensory evaluations were conducted to assess consumer preferences. The results showed that the new formulations are rich in oil (45.15-52.24 g/100 g), carbohydrates (40.26-46.81 g/100 g), and protein (3.15-3.92 g/100 g). Mineral analysis revealed significant amounts of potassium (443-578 mg/100 g), calcium (98-124 mg/ 100 g), phosphorus (50-65 mg/100 g), and magnesium (38-50 mg/100 g). The Z. lotus-based products exhibited higher phenolic content (7-12 mg GAE/g), flavonoids (7.10-10.18 mg QE/g), and stronger antioxidant activities using DPPH radical scavenging activity (3.55-11.14 mg AAE/ g) and FRAP (5.39-8.55 mg AAE/g). Moreover, the new product retains the beneficial fatty acid profile of argan oil, with a high content of oleic acid (48 %) and linoleic acid (32 %). Sensory evaluation indicated that the formulation consisting of 45 % Z. lotus powder, 50 % argan oil, and 5 % honey was the most appreciated for taste and texture. These findings suggest that incorporating Z. lotus into traditional Amlou recipes not only enhances nutritional and antioxidant properties but also meets consumer acceptance in terms of flavor and texture.
... 50%), tokoferole (głównie γ-tokoferol) czy polifenole (kwas ferulowy). Olej arganowy zawiera także skwalen (węglowodór wykazujący podobieństwo do karotenów i koenzymu Q10) [29]. Składniki te odpowiadają za nawilżenie, ochronę błon komórkowych przed utlenianiem lipidów i działaniem reaktywnych form tlenu. ...
Article
Background. Vegetable oils play an important role in the food, pharmaceutical and cosmetic indus tries. They are not only a source of nutrients, but also a carrier of bioactive substances as an ingredient of creams or emulsions. Some oils, like extra virgin olive oil or argan oil, due to high consumer demand and high prices, may be subject to adulteration by using cheaper and easily accessible oils. Hence, the need to develop new research methods enabling the quick identification of such adulterations, but also enabling the assessment of oil quality, e.g. in variable storage conditions. Typically, gas chromatography (GC) is used to assess the profile of fatty acids. Oil parameters such as acid number, peroxide value and iodine number are also assessed to determine oil quality. Nevertheless, instead of performing all the above mentioned tests, these parameters can also be determined directly from 1H NMR spectra. Hence, there is great potential for using this method in quick screening of oil quality. The 1H NMR technique has been growing in importance in recent years in researching the quality and composition of food, including vege table oils. Multidimensional NMR techniques and analysis of other nuclei (13C NMR) are also used in the study of oils. The aim of this work is to present the applications of the most commonly used 1H NMR technique. Results and Conclusions. The article contains examples of the application of this method in testing the composition, quality and authenticity of olive oil, hemp oil and argan oil as oils used (both in the food, medical or cosmetic context) and becoming more and more popular among consumers.
... Approximately 69% of the tocopherol content of argan oil is made up of gamma-tocopherol, the most effective free-radical scavenger of all tocopherols (Jiang et al., 2001;Almuhayawi et al., 2023a). It is hypothesized that a particular mix of chemicals present in the unsaponifiable matter contributes to the therapeutic effects of argan oil because sterols and tocopherols can work together synergistically (El Monfalouti et al., 2010). Natural medicines are increasingly used worldwide, particularly in developing nations where more expensive and sophisticated treatments are not always available. ...
Article
Full-text available
Active components in medicinal plants provide unlimited useful and traditional medicines. Antimicrobial activities are found in secondary metabolites in plant extracts such as argan oil. This experimental investigation aims to determine argan oil’s volatile compounds and examine their in vitro antimicrobial properties. In silico simulations, molecular docking, pharmacokinetics, and drug-likeness prediction revealed the processes underlying the in vitro biological possessions. Gas chromatography–mass spectrometry (GC/MS) was used to screen argan oil’s primary components. In silico molecular docking studies were used to investigate the ability of the selected bioactive constituents of argan oil to act effectively against Pseudomonas aeruginosa and Staphylococcus aureus (S. aureus) isolated from infections. The goal was to study their ability to interact with both bacteria’s essential therapeutic target protein. The 21 chemicals in argan oil were identified by GC/MS. Docking results for all compounds with S. aureus and P. aeruginosa protease proteins ranged from −5 to −9.4 kcal/mol and −5.7 to −9.7 kcal/mol, respectively, compared to reference ligands. Our docking result indicates that the 10-octadecenoic acid, methyl ester was the most significant compound with affinity scores of −9.4 and −9.7 kcal/mol for S. aureus and P. aeruginosa proteins, respectively. The minimal bactericidal concentration (MBC) and minimal inhibitory concentration (MIC) of argan oil were 0.7 ± 0.03 and 0.5 ± 0.01 for S. aureus and 0.4 ± 0.01 and 0.3 ± 0.02 for P. aeruginosa, respectively. We confirmed the antimicrobial properties of argan oil that showed significant growth inhibition for S. aureus and P. aeruginosa.
Article
Full-text available
Adolescence is a critical period when the effects of ethanol and stress exposure are particularly pronounced. Argan oil (AO), a natural vegetable oil known for its diverse pharmacological benefits, was investigated for its potential to mitigate addictive-like behaviors and brain damage induced by adolescent intermittent ethanol intoxication (IEI) and unpredictable mild stress (UMS). From P30 to P43, IEI rats received a daily ip ethanol (3 g/kg) on a two-day on/two-day off schedule. On alternate days, the rats were submitted to UMS protocol. Next, a two-bottle free access paradigm was performed over 10 weeks to assess intermittent 20% ethanol voluntary consumption. During the same period, the rats were gavaged daily with AO (15 mL/kg). Our results show that IEI/UMS significantly increased voluntary alcohol consumption (from 3.9 g/kg/24 h to 5.8 g/kg/24 h) and exacerbated withdrawal signs and relapse-like drinking in adulthood. Although AO treatment slightly reduced ethanol intake, it notably alleviated withdrawal signs during abstinence and relapse-like drinking in adulthood. AO’s effects were associated with its modulation of the HPA axis (elevated serum corticosterone), restoration of amygdala oxidative balance, BDNF levels, and attenuation of neurodegeneration. These findings suggest that AO’s neuroprotective properties could offer a potential therapeutic avenue for reducing ethanol/stress-induced brain damage and addiction. Further research is needed to explore its mechanisms and therapeutic potential in alcohol use disorders.
Article
Full-text available
Argan tree (Argania spinosa (L.) Skeels) is endemic in Morocco. The aroma compounds of argan oil prepared from roasted and unroasted argan kernels were analyzed using GC-MS and olfactometry. Influence of the fruit peeling method on the olfactometric parameters was also studied. Oil coming from unroasted kernels furnished fourteen compounds if the fruits had been mechanically-peeled fruits (uRK), and twenty two when the kernels had been goat digested (GuRK). Thirteen compounds were common to the two studies. The oil obtained from roasted kernels of mechanically-peeled fruits (RK) furnished nineteen compounds. Twenty one were isolated from the oil obtained from roasted kernels of goat digested fruits (GRK). Twelve compounds were common to the two analyses. In all oil samples, the aldehyde/ketone derivatives composed the largest group of odorants. Acetophenone and p-methylacetophenone appear to be the most important contributors to the RK oil aroma. The unpleasant smell presented by argan oil prepared from naturally-peeled argan fruits (GuRK, GRK) could result from the presence of one or two odorants presenting a rancid odor.
Article
Full-text available
A substantial body of evidence supports the conclusion that chronic inflammation is a causative factor in a variety of cancers. Inflammatory mediators include metabolites of arachidonic acid, cytokines, chemokines, and free radicals. These mediators increase cell proliferation, mutagenesis, oncogene activation, with ultimately the loss of cell growth control. Among the nutritional factors that can influence inflammation and cancerogenesis, fatty acids are clearly the most directly involved. Indeed, omega-3 and omega-6 polyunsaturated fatty acids exert opposite effects on inflammation and potentially on tumor formation. The present review analyses in a non-exhaustive manner some of the mechanisms that have been proposed to explain how omega-6 can be detrimental while omega-3 have beneficial effects.
Article
Full-text available
For years, in southwestern Morocco, the decline of the argan forest has been accompanied by the concomitant desert encroachment. Preservation of this forest by increasing the economic value of argan tree was proposed twenty years ago, but successful large scale production of certified, high quality argan oil, an edible oil introduced as a functional food, has only been recently achieved. Argan oil is now marketed in most developed countries, despite its elevated price, and protection of the argan forest is now seriously being considered. The aim of this work is to present the recent progress made in argan oil production, the ways explored to commercialize the oil extraction by-products, and recent attempts to use other argan tree parts as part of a long term aim to preserve the argan forest.
Patent
A composition which includes a pulp extract from the fruit of Argania spinosa and at least one dermopharmaceutical or cosmetic auxiliary and/or additive is provided. A process for producing an extract from the fruit of Argania spinosa, and a triterpene fraction of an extract of the pulp of the fruit of Argania spinosa including lupeol, α-amyrine, β-amyrine, taraxasterol, and psi-taraxasterol are also provided.
Article
Thyroid hormones affect reactions in almost all pathways of lipid metabolism. It has been reported that plasma free fatty acid (FFA) concentration in hypothyroidism is generally within the normal range. In this study, however, we show that plasma FFA concentration in some hypothyroid patients is higher than the normal range. Symptoms of thyroid dysfunction in these individuals were less severe than those of patients with lower plasma FFA concentrations. From these findings we hypothesized that the change in FFA concentration must correlate with thyroid function. Using an animal model, we then examined the effect of highly purified eicosapentaenoic acid ethyl ester (EPA-E), a n-3 polyunsaturated fatty acid derived from fish oil, on thyroid function in 1-methyl-2-imidazolethiol (MMI)-induced hypothyroid rats. Oral administration of EPA-E inhibited reduction of thyroid hormone levels and the change of thyroid follicles in MMI-induced hypothyroid rats. These findings suggest that FFA may affect thyroid functions and EPA-E may prevent MMI-induced hypothyroidism.
Article
Sensory quality of edible oil is essential to get the consumer acceptance. Modifications during processing can alter edible oil sensory quality. The storage stability and sensory quality of argan oil prepared from (1) mechanically pressed unroasted kernels, (2) mechanically pressed roasted kernels, (3) hand-pressed roasted kernels, and (4) hand-pressed roasted kernels coming from goat-digested fruits was studied at room temperature and under accelerated conditions (60°C). The roasting process had a positive effect on storage stability of the resulting oils, while argan oil prepared from mechanically pressed roasted kernels provides the optimum storage stability. Oil from hand-pressed roasted kernels originating from goat-digested fruits was not suitable for human consumption because of the unpleasant taste and odoûr. Only oil from mechanically pressed roasted kernels did not produce negative sensory attributes like fusty or Roquefort cheese.
Article
For good scientific reasons it has been argued that the Mediterranean diet has beneficial anticarcinogenic effects, evidenced by a relatively long cancer-free survival. Olive oil plays an important culinary role in the different regions of the Mediterranean basin, providing a legitimate reason to hypothesize that its constituents could exert a beneficial effect in cancer prevention. Indeed, many experimental studies have shown that both the monounsaturated oleic acid, the major lipid in olive oil, and minor olive oil components exert an anticancer effect, particularly on breast cancer and colon cancer cells. A recent meta-analysis by Sofi et al. (2008) provided solid evidence that adherence to the Mediterranean diet is positively correlated with a diminished cancer risk and there is a growing understanding that olive oil components act in an integrated manner with other molecules present in the diet. Data from epidemiological studies consistently show a beneficial effect of olive oil consumption on reducing breast cancer, but -up until now-not for colon cancer. Olive oil and olive oil phenolics have been positively associated with reduced oxidative DNA damage in humans. These encouraging findings need further confirmation in human interventional trials or large cohort studies in order to determine how this translates into decreased cancer incidence. Copyright © 2009 Prous Science, S.A.U. or its licensors. All rights reserved.