Exposure to Diesel Motor Exhaust and Lung Cancer Risk in a Pooled Analysis from Case-Control Studies in Europe and Canada

International Agency for Research on Cancer, Lyon, France.
American Journal of Respiratory and Critical Care Medicine (Impact Factor: 13). 10/2010; 183(7):941-8. DOI: 10.1164/rccm.201006-0940OC
Source: PubMed


Diesel motor exhaust is classified by the International Agency for Research on Cancer as probably carcinogenic to humans. The epidemiologic evidence is evaluated as limited because most studies lack adequate control for potential confounders and only a few studies have reported on exposure-response relationships.
Investigate lung cancer risk associated with occupational exposure to diesel motor exhaust, while controlling for potential confounders.
The SYNERGY project pooled information on lifetime work histories and tobacco smoking from 13,304 cases and 16,282 controls from 11 case-control studies conducted in Europe and Canada. A general population job exposure matrix based on ISCO-68 occupational codes, assigning no, low, or high exposure to diesel motor exhaust, was applied to determine level of exposure.
Odds ratios of lung cancer and 95% confidence intervals were estimated by unconditional logistic regression, adjusted for age, sex, study, ever-employment in an occupation with established lung cancer risk, cigarette pack-years, and time-since-quitting smoking. Cumulative diesel exposure was associated with an increased lung cancer risk highest quartile versus unexposed (odds ratio 1.31; 95% confidence interval, 1.19-1.43), and a significant exposure-response relationship (P value < 0.01). Corresponding effect estimates were similar in workers never employed in occupations with established lung cancer risk, and in women and never-smokers, although not statistically significant.
Our results show a consistent association between occupational exposure to diesel motor exhaust and increased risk of lung cancer. This association is unlikely explained by bias or confounding, which we addressed by adjusted models and subgroup analyses.

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Available from: Dario Consonni, Dec 17, 2013
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    • "Our significant OR for DME provides rather weak evidence, as we could not devise a cumulative exposure estimate. However, our results are again comparable both with respect to the prevalence of exposure and OR to a recent combined analysis of 11 case – control studies from Europe and Canada (Olsson et al, 2011), which found an overall 37% prevalence among controls and a summary OR of 1.4 in the highest exposure group. "
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    • "Recently, a large pooled analysis of case–control studies on the joint effects of occupational carcinogens and smoking in the development of lung cancer was initiated (Olssonetal.,2011).Thisprojectiscalled'SYNERGY'. Up until now, 14 lung cancer case–control studies from 13 European countries (Czech Republic, France, Germany , Hungary, Italy, the Netherlands, Poland, Romania , Russia, Slovakia, Spain, Sweden, and the UK) and Canadahavebeenincluded.Together,thesestudiescomprise 39 518 subjects:17 705 cases and 21 813 controls. "
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