Inactivated Seasonal Influenza Vaccines Increase Serum Antibodies to the Neuraminidase of Pandemic Influenza A(H1N1) 2009 Virus in an Age-Dependent Manner

Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
The Journal of Infectious Diseases (Impact Factor: 6). 10/2010; 202(11):1634-8. DOI: 10.1086/657084
Source: PubMed


Levels of preexisting antibodies to the hemagglutinin of pandemic influenza A(H1N1) 2009 (hereafter pandemic H1N1) virus positively
correlate with age. The impact of contemporary seasonal influenza vaccines on establishing immunity to other pandemic H1N1
proteins is unknown. We measured serum antibodies to the neuraminidase (NA) of pandemic H1N1 in adults prior to and after
vaccination with seasonal trivalent inactivated influenza vaccines. Serum antibodies to pandemic H1N1 NA were observed in
all age groups; however, vaccination elevated levels of pandemic H1N1 NA antibodies predominately in elderly individuals (age,⩾60
years). Therefore, contemporary seasonal vaccines likely contribute to reduction of pandemic H1N1-associated disease in older

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Available from: Nicholas Negovetich
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    • "The immunogenicity of different influenza vaccine formulations was studied in the 1970s; despite the fact that whole virus was found to be more immunogenic compared to other formulations, its use was discontinued in most countries and it was replaced with the less reactogenic split or subunit influenza vaccine18192021. Although the latter have been proven to be safe, several studies have demonstrated decreased magnitude and longevity of the immune responses after intramuscular administration especially in high risk groups such as the elderly, immunocompromised individuals and children222324. These facts strongly suggest the necessity for new vaccine formulations or new delivery methods that could improve the immune responses, thus reducing morbidity and mortality from influenza infection worldwide. "
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