The effects of time-released garlic powder tablets on multifunctional cardiovascular risk in patients with coronary artery disease

Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow 125315, Russia.
Lipids in Health and Disease (Impact Factor: 2.22). 10/2010; 9(1):119. DOI: 10.1186/1476-511X-9-119
Source: PubMed


The double-blinded placebo-controlled randomized study has been performed in 51 coronary heart disease (CHD) patients to estimate the effects of time-released garlic powder tablets Allicor on the values of 10-year prognostic risk of acute myocardial infarction (fatal and non-fatal) and sudden death, with the respect of secondary CHD prevention. It has been demonstrated that 12-month treatment with Allicor results in the significant decrease of cardiovascular risk by 1.5-fold in men (p < 0.05), and by 1.3-fold in women. The above results were equitable also in terms of relative risks. The main effect that played a role in cardiovascular risk reduction was the decrease in LDL cholesterol by 32.9 mg/dl in men (p < 0.05), and by 27.3 mg/dl in women. Thus, the most significant effects were observed in men, while in women the decrease of cardiovascular risk appeared as a trend that might be due presumably to the insufficient sample size. Since Allicor is the remedy of natural origin, it is safe with the respect to adverse effects and allows even perpetual administration that may be crucial for the secondary prevention of atherosclerotic diseases in CHD patients.

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    • "patients. Thus, it was found that the garlic powder has antiatherosclerotic effect in a dose range of 50–300 mg and half-maximal effect was achieved at a dose of 100 mg and the maximal effect was achieved at a dose of 150 mg [27]. Thus, the data obtained in experiments utilizing the ex vivo model allowed to conclude that natural products including "
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    • "Studies have shown that the most effective way to reduce CVD is to try and reduce all the risk factors. Garlic-based preparations is thought to be promising agents for multifunctional risk reduction, but the mode of action remains slightly obscure [14]. "

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