The Swedish Multi-Generation Register

Department of Medicine, Karolinska Institute, Stockholm, Sweden.
Methods in molecular biology (Clifton, N.J.) (Impact Factor: 1.29). 01/2011; 675:215-20. DOI: 10.1007/978-1-59745-423-0_10
Source: PubMed


The Swedish Multi-generation Register consists of data of more than nine million individuals, with information available on mothers in 97% and on fathers in 95% of index persons. Index persons are confined to those born from 1932 onwards and those alive on January 1, 1961. This register is a unique resource but is still underutilized.

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    ABSTRACT: In 1974, Sweden became the first country to permit fathers to take paid parental leave. Other countries are currently following suit issuing similar laws. While this reform supports the principles of the United Nations convention of the right for children to be with both parents and enshrines the ethos of gender equality, there has been little systematic examination of its potential impact on child health. Instead, there is uninformed debate that fathers may expose their children to greater risks of injury than mothers. In this Swedish national study, the authors therefore assess whether fathers' parental leave can be regarded as a more serious risk factor for child injuries than that of mothers. Nationwide register-based ecological and longitudinal studies of hospitalisation due to injury (and intoxication) in early childhood, involving the Swedish population in 1973-2009 (ecological design), and children born in 1988 and 1989 (n=118 278) (longitudinal design). An increase in fathers' share of parental leave over time was parallelled by a downward trend in child injury rates (age 0-4 years). At the individual level, the crude incidence of child injury (age 0-2 years) was lower during paternity as compared with maternity leave. This association was, however, explained by parental socio-demographic characteristics (multivariate HR 0.96, 95% CI 0.74 to 1.2). There is no support for the notion that paternity leave increases the risk of child injury.
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    ABSTRACT: OBJECTIVE: Exposure to elemental mercury vapor can impair neurological function as it is neurotoxic in doses higher than usually found in dentistry. Little is known about the potential effects of fetal exposure to elemental mercury among offspring of female dental workers. We investigated cognitive function among offspring of women working in dentistry at the time of their pregnancy. METHODS: We compared results for cognitive function examinations taken by the majority of young men in Sweden at the time of compulsory military enlistment (age 17-18 years). Sons of female dentists (N=365) and dental nurses (N=3181) born during the 1960-1970s were compared with sons of female physicians (N=378) and assistant nurses (N=12 667). RESULTS: Analysis by linear regression showed that sons of dental workers had similar or higher cognitive function test results compared to their matched cohorts. CONCLUSION: We found no evidence of poorer cognitive function among male offspring of female dentists or dental nurses.
    Full-text · Article · Feb 2012 · Scandinavian Journal of Work, Environment & Health
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    ABSTRACT: Comorbid inflammatory conditions in multiple sclerosis (MS) patients suggest shared risks with MS. To estimate if the risk of immune-mediated disease in MS patients and their parents is increased. Swedish register data were analysed using Cox regression to estimate immune-mediated disease risk among 11284 fathers and 12006 mothers of MS patients, compared with 123158 fathers and 129409 mothers of index subjects without MS. Similar analyses were conducted among 20276 index subjects with MS and 203951 without. Parents of patients with MS did not have a significantly altered immune-mediated disease risk. Patients with MS had a consistently raised risk for several immune-mediated diseases: ulcerative colitis, Crohn's disease, type 1 diabetes, psoriasis, polyarthritis nodosa and pemphigoid. The risk was more pronounced for diseases diagnosed subsequent to MS onset. The increased occurrence of other immune-mediated diseases in MS patients may not be due to shared genetic factors and surveillance bias is likely to be the main or possibly the entire explanation. If not entirely explained by surveillance bias, a modestly raised occurrence of comorbid diseases may be due to shared environmental risks or factors related to MS disease characteristics.
    Full-text · Article · Mar 2012 · Multiple Sclerosis
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