Plasma F2-isoprostane level and cognitive function over eight years in non-demented older adults: Findings from the Health ABC Study
Department of Psychiatry, School of Medicine, University of California, San Francisco, CA, USA.Prostaglandins Leukotrienes and Essential Fatty Acids (Impact Factor: 2.35). 02/2011; 84(1-2):57-61. DOI: 10.1016/j.plefa.2010.09.001
F2-isoprostanes (F2-IsoP) are reportedly increased in dementia patients, and are considered a reliable biomarker of oxidation. However, few studies have examined the predictive value of peripheral F2-IsoP levels in non-demented older adults. This study assesses the association between plasma F2-IsoP and change in cognitive function in non-demented elderly over eight years. Plasma F2-IsoP was measured by gas chromatography-mass spectrometry in a biracial cohort of 726 elderly men and women. Digit Symbol Substitution test and the Modified Mini-Mental State Exam were administered over time. No association was found between F2-IsoP tertile and baseline or change (slope) in cognitive function over eight years. Plasma F2-IsoP is not a valuable biomarker in predicting cognitive change over years in non-demented older adults.
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