Article

Amoxicillin degradation at ppb levels by Fenton's oxidation using design of experiments Science of the Total Environment

LEPÆ, Departamento de Engenharia Química, Faculdade de Engenharia da Universidade do Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal.
Science of The Total Environment (Impact Factor: 4.1). 11/2010; 408(24):6272-80. DOI: 10.1016/j.scitotenv.2010.08.058
Source: PubMed

ABSTRACT

A central composite factorial design methodology was employed to optimise the amoxicillin degradation using the Fenton's oxidation treatment. In this study, the variables considered for the process optimisation were the hydrogen peroxide and ferrous ion initial concentrations and the temperature, for an antibiotic concentration of 450μg L(-1) at pH=3.5. This methodology also allowed assessing and identifying the effects of the different factors studied and their interactions in the process response. An appropriate quadratic model was developed in order to plot the response surface and contour curves, which was used to perform the process optimisation. From this study, it was concluded that ferrous ion concentration and temperature were the variables that most influenced the response. Under the optimal conditions (hydrogen peroxide concentration=3.50-4.28mg L(-1), ferrous ion concentration=254-350μg L(-1) and temperature=20-30°C), it was possible to achieve total amoxicillin degradation after 30min of reaction.

3 Followers
 · 
31 Reads
  • Source
    • "In this context, response surface methodology (RSM) is an alternative method to minimize the experiments' number and evaluate the interaction effects. In addition, statistical models to represent the desired response as a function of studied variables can be generated [18] [19] [20] [21] [22] [23]. "
    [Show abstract] [Hide abstract]
    ABSTRACT: A statistical optimization of Reactive Red 141 (RR141) removal by heterogeneous photo–Fenton reaction using ZnFe2O4 particles was performed. ZnFe2O4 oxide was synthesized by microwave-assisted solvothermal route and characterized by X–ray diffraction, Fourier transform infrared spectroscopy, and N2 adsorption–desorption isotherms. This material was used as a catalyst for the removal of RR141 dye from aqueous solution. Statistical optimization for the RR141 removal was performed using a 24−1 fractional experimental design, followed by the response surface methodology. Effects of pH, reaction time, dye concentration, and H2O2 concentration were evaluated. ZnFe2O4 particles presented a mesoporous structure with surface area of 65 m2 g−1. It was found that the more adequate conditions for the RR141 dye removal were pH 2.0, reaction time of 60 min, dye concentration of 60 mg L−1, and H2O2 concentration of 10 mM. In these conditions, 90% of color removal was achieved. The results demonstrate that the ZnFe2O4 oxide is an efficient catalyst for the removal of RR141dye from aqueous solution through the heterogeneous photo–Fenton reaction.
    Full-text · Article · Jul 2015 · Desalination and water treatment
  • Source
    • "These compounds eliminate the effective micro-organisms required in biological wastewater treatment [6] and decrease the efficiency of the treatment plants [9]. Antibiotics are resistant to biodegradation process; therefore , the conventional wastewater treatment methods, are not capable of removing these compounds [6]. Advanced oxidation processes (AOPs) is an efficient environmentally friendly method in which hydroxyl radicals (OH˚) are used to oxidize recalcitrant organic pollutants and convert them to harmless end products such as H 2 O and CO 2 [10]. "
    [Show abstract] [Hide abstract]
    ABSTRACT: In recent years, antibiotics have been considered as serious contaminants due to their high consumption and persistence in the aquatic environment. Currently, amoxicillin is one of the most widely used antibiotics and its emission into the environment encounters numerous health and environmental hazards. The main objectives of this research were focused on assessing the feasibility of using Fenton reagent in removing amoxicillin and determining the optimal conditions using Taguchi method. In addition, its effect on the rate of mineralization, biodegradation, and the removal efficiency of COD were studied. The Taguchi method was used to optimize variables and their levels using Qualitek-4 (w32b) software. The optimum values of the response variables were predicted using signal-to-noise ratio (S/N). The influence of different parameters including the initial concentration of amoxicillin, H2O2 concentration, Fe(II) concentration, pH, and reaction time at four different levels on the removal of amoxicillin in the aqueous phase were investigated. The removal efficiencies at initial concentrations of amoxicillin 10, 100, 200, and 500 mg/L were 68.64, 95.385, 98, and 99.3%, respectively. Process optimization by Taguchi method suggests that the optimal conditions for the removal of amoxicillin in the aqueous phase are as follows: the initial amoxicillin concentration of 500 mg/L, Fe(II) concentration of 5.0 mg/L, H2O2 concentration of 500 mg/L, pH 3, and the reaction time of 15 min; and level of significance for the study parameters were 60.228, 26.369, 5.638, 4.373, and 3.392, respectively. The maximum removal efficiency of COD and mineralization rate were 71.3 and 36.3%, respectively. The biodegradation rate was also increased from 0 to 0.738. In conclusion, our study demonstrated that Fenton process may enhance the rate of amoxicillin degradation in polluted water and could be used as a pretreatment step for the biological removal. The results also indicate that the Taguchi experimental design can simply predict the optimal conditions for the removal of amoxicillin in the aqueous phase using Fenton process.
    Full-text · Article · Mar 2015 · Desalination and water treatment
  • Source
    • "These compounds eliminate the effective micro-organisms required in biological wastewater treatment [6] and decrease the efficiency of the treatment plants [9]. Antibiotics are resistant to biodegradation process; therefore , the conventional wastewater treatment methods, are not capable of removing these compounds [6]. Advanced oxidation processes (AOPs) is an efficient environmentally friendly method in which hydroxyl radicals (OH˚) are used to oxidize recalcitrant organic pollutants and convert them to harmless end products such as H 2 O and CO 2 [10]. "
    [Show abstract] [Hide abstract]
    ABSTRACT: In recent years, antibiotics have been considered as serious contaminants due to their high consumption and persistence in the aquatic environment. Currently, amoxicillin is one of the most widely used antibiotics and its emission into the environment encounters numerous health and environmental hazards. The main objectives of this research were focused on assessing the feasibility of using Fenton reagent in removing amoxicillin and determining the optimal conditions using Taguchi method. In addition, its effect on the rate of mineralization, biodegradation, and the removal efficiency of COD were studied. The Taguchi method was used to optimize variables and their levels using Qualitek-4 (w32b) software. The optimum values of the response variables were predicted using signal-to-noise ratio (S/N). The influence of different parameters including the initial concentration of amoxicillin, H2O2 concentration, Fe(II) concentration, pH, and reaction time at four different levels on the removal of amoxicillin in the aqueous phase were investigated. The removal efficiencies at initial concentrations of amoxicillin 10, 100, 200, and 500 mg/L were 68.64, 95.385, 98, and 99.3%, respectively. Process optimization by Taguchi method suggests that the optimal conditions for the removal of amoxicillin in the aqueous phase are as follows: the initial amoxicillin concentration of 500 mg/L, Fe(II) concentration of 5.0 mg/L, H2O2 concentration of 500 mg/L, pH 3, and the reaction time of 15 min; and level of significance for the study parameters were 60.228, 26.369, 5.638, 4.373, and 3.392, respectively. The maximum removal efficiency of COD and mineralization rate were 71.3 and 36.3%, respectively. The biodegradation rate was also increased from 0 to 0.738. In conclusion, our study demonstrated that Fenton process may enhance the rate of amoxicillin degradation in polluted water and could be used as a pretreatment step for the biological removal. The results also indicate that the Taguchi experimental design can simply predict the optimal conditions for the removal of amoxicillin in the aqueous phase using Fenton process.
    Full-text · Article · Jan 2015 · Desalination and water treatment
Show more