Pyramidal Neurons Are Generated from Oligodendroglial Progenitor Cells in Adult Piriform Cortex

Institute for Pediatric Regenerative Medicine, University of California, Davis School of Medicine, Sacramento, California 95817, USA.
The Journal of Neuroscience : The Official Journal of the Society for Neuroscience (Impact Factor: 6.34). 09/2010; 30(36):12036-49. DOI: 10.1523/JNEUROSCI.1360-10.2010
Source: PubMed


Previous studies have shown that oligodendroglial progenitor cells (OPCs) can give rise to neurons in vitro and in perinatal cerebral cortex in vivo. We now report that OPCs in adult murine piriform cortex express low levels of doublecortin, a marker for migratory and immature neurons. Additionally, these OPCs express Sox2, a neural stem cell marker, and Pax6, a transcription factor characteristic of progenitors for cortical glutamatergic neurons. Genetic fate-mapping by means of an inducible Cre-LoxP recombination system proved that these OPCs differentiate into pyramidal glutamatergic neurons in piriform cortex. Several lines of evidence indicated that these newly formed neurons became functionally integrated into the cortical neuronal network. Our data suggest that NG2(+)/PDGFRα(+) proteolipid protein promoter-expressing progenitors generate pyramidal glutamatergic neurons within normal adult piriform cortex.

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    • "yama et al . , 2014 ) . The confusion is due in large part to the cell ' s multipotency . While predominantly a pool for OLs – and hence considered OPCs – NG2 - expressing cells also generate protoplasmic astrocytes and a small number of region - specific neurons ( though the latter is hotly debated ) ( Rivers et al . , 2008 ; Zhu et al . , 2008 ; Guo et al . , 2010 ; Kang et al . , 2010 ) . Recent evidence further suggests that NG2 cells are capable of receiving and reacting to neuronal input , though no defini - tive biological function has been ascribed [ reviewed by Hill and Nishiyama ( 2014 ) ] . To generate consensus and acknowledge the NG2 population as distinct , an umbrella term , polydendr"
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