A Novel Controlled Release Drug Delivery System for Multiple Drugs Based on Electrospun Nanofibers Containing Nanoparticles

Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400030, China.
Journal of Pharmaceutical Sciences (Impact Factor: 2.59). 12/2010; 99(12):4805-11. DOI: 10.1002/jps.22189
Source: PubMed


This study describes development of a novel controlled drug release system for multiple drugs, it consisted of Chitosan nanoparticles/PCL composite electrospun nanofibers with core-sheath structures. Two model agents' rhodamine B and naproxen were successfully loaded in the core and sheath region respectively. The behavior of these two agents demonstrated a good controlled release and temporality, providing a new way to obtain program or temporality release for multiple agents. Particularly, this is potential applications in the field of tissue engineering, sutures and wound dressings.

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    • "In this work, we describe a novel self-assembled 3D structure formed by biodegradable NPs able to swell in physiological conditions and that can be used for multiple release of hydrophilic and hydrophobic drugs. To the best of our knowledge these multiple drug delivery systems are generally constituted by different loaded polymers layered one above the other [26] [27]. With the approach here presented hydrophobic drugs could be loaded within NPs, while hydrophilic ones remain trapped in the aqueous interstices that they create during NPs assembly. "
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    ABSTRACT: Polymer nanoparticles (NPs) have recently attracted increasing attention and represent one of the main and important novelties in nanomedicine. In particular, they exhibit several advantages like the ability to tailor and sustain the release of hydrophobic drugs, high biocompatibility and degradability, together with the possibility to be highly cell selective. However, the usage of NPs in several diseases can be limited by their route of administration: in fact their diffuse distribution in tissues and organs does not allow to address them specifically in the target situ limiting therapeutic outcome and increasing potential side effects. In this work we studied the self-assembly of opposite charged polymer nanoparticles able to retain aqueous solutions, with the aim of creating self-assembled macrostructures that can release both hydrophobic and hydrophilic compounds. NPs were synthesized with a two-steps process starting from ε-caprolactone and hydroxyethyl methacrylate to create biodegradable macromonomers which were then co-polymerized in an emulsion polymerization with methacrylic acid and either a positive charged surfmer (HEMA-Ch+) or a negative one (HEMA-SO3−). The feasibility to assemble these NPs into macrostructures was studied and the structures of the final products as well as their ability to release mimetic drugs were evaluated.
    No preview · Article · Jul 2015 · European Polymer Journal
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    • "Various magnetic drug delivery systems using biodegradable polymers have been reported [5] [6]. Drug delivery systems were also developed from electrospun fibers containing nanoparticles [7] "
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    ABSTRACT: Composite nanofibers have received a lot of attention due to their multifunctional behavior. Some interesting properties can be induced in nanofiber through incorporation of nanoparticles. In present work, PVA-pectin-magnetite nanofiber was prepared using electrospinning method. The morphological studies of the composite nanofibers were performed by AFM (atomic force microscope) and by FE-SEM (field emission scanning electron microscope). The chemical composition of the imaged nanofibers was determined from energy dispersive X-ray spectrometry (EDX). The magnetic property of the nanofibers was due to incorporation of Fe 3 O 4 nanoparticles, which was corroborated from VSM study exhibiting ferromagnetic property and negligible coercivity (saturation magnetization = 9. 34 emu/g). The Fe 3 O 4 phase was further confirmed form XRD study. The loading and release of diclofenac sodium drug from the as-synthesized nanofibers was studied by UV-Visible spectroscopy. The loading of drug was 56. 78 µg mg -1 and exhibited burst release at pH 7. 4 PBS. 630 Pritam Roy and Raj Kumar Dutta
    Full-text · Article · Jun 2014 · International Journal of Applied Engineering Research
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    • "Therefore, drug-loaded electrospun nanofibers display obvious advantages when applied as tissue engineering scaffolds, wound healing materials, abdominal anti-adhesions after surgical procedure, or in post-operative local chemotherapy [16] [17] [18]. So far, a number of different drug loading methods have been developed to prepare drug-loaded nanofibers [19] [20] [21] [22] [23] [24] [25] [26]. Typically, drug-loaded nanofibers can be formed easily and directly by electrospinning polymer blends/mixtures with drugs. "
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    ABSTRACT: Fabrication of nanofiber-based drug delivery system with controlled release property is of general interest in biomedical sciences. In this study, we prepared an antibiotic drug tetracycline hydrochloride (TCH)-loaded halloysite nanotubes/poly(lactic-co-glycolic acid) composite nanofibers (TCH/HNTs/PLGA), and evaluated the drug release and antibacterial activity of this drug delivery system. The structure, morphology, and mechanical properties of the formed electrospun TCH/HNTs/PLGA composite nanofibrous mats were characterized using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy, and tensile testing. We show that the incorporation of TCH-loaded HNTs within the PLGA nanofibers is able to improve the tensile strength and maintain the three-dimensional structure of the nanofibrous mats. In vitro viability assay and SEM morphology observation of mouse fibroblast cells cultured onto the fibrous scaffolds demonstrate that the developed TCH/HNTs/PLGA composite nanofibers are cytocompatible. More importantly, the TCH/HNTs/PLGA composite nanofibers are able to release the antibacterial drug TCH in a sustained manner for 42 days and display antimicrobial activity solely associated with the encapsulated TCH drug. With the improved mechanical durability, sustained drug release profile, good cytocompatibility, and non-compromised therapeutic efficacy, the developed composite electrospun nanofibrous drug delivery system may be used as therapeutic scaffold materials for tissue engineering and drug delivery applications.
    Full-text · Article · Apr 2013 · Colloids and surfaces B: Biointerfaces
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