Early treatment of candidemia in adults: A review

ArticleinMedical mycology: official publication of the International Society for Human and Animal Mycology 49(2):113-20 · February 2011with22 Reads
Impact Factor: 2.34 · DOI: 10.3109/13693786.2010.512300 · Source: PubMed

    Abstract

    Invasive candidiasis is associated with high mortality, particularly in adults. Retrospective studies show that shorter times to treatment are correlated with a lower risk of death. A number of factors can be used to predict which patients would benefit from antifungal prophylaxis or early (pre-emptive or empirical) therapy. Detection of the fungal cell wall component (1→3)-β-D-glucan (BDG) shows promise as an early biomarker of invasive fungal infection and may be useful in identifying patients who would benefit from early antifungal treatment. To date, no consistent early treatment strategy has evolved. Proof-of-concept studies are needed to assess the role of pre-emptive and empirical therapy in ICU patients and the relevance of BDG as an early marker of infection.