ChemInform Abstract: Room-Temperature Palladium-Catalyzed Cross-Coupling of Aryltrimethylammonium Triflates with Aryl Grignard Reagents.

ArticleinOrganic Letters 12(19):4388-91 · October 2010with8 Reads
Impact Factor: 6.36 · DOI: 10.1021/ol1018739 · Source: PubMed


    Aryltrimethylammonium triflates and tetrafluoroborates were found to be highly reactive electrophiles in the Pd-catalyzed cross coupling with aryl Grignard reagents. The coupling reactions proceed at ambient temperature with a nearly stoichiometric quantity of Grignard reagent, and diverse functionality is tolerated. Competition experiments established the reactivity of PhNMe(3)OTf relative to PhCl, PhBr, PhI, and PhOTf.