Polymorphism in tumor necrosis factor-related apoptosis-inducing ligand receptor 1 is associated with poor viral response to interferon-based hepatitis C virus therapy in HIV/hepatitis C virus-coinfected individuals

Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.
AIDS (London, England) (Impact Factor: 5.55). 11/2010; 24(17):2639-44. DOI: 10.1097/QAD.0b013e32833eacfd
Source: PubMed


HIV/hepatitis C virus (HCV) coinfection causes accelerated liver disease compared to HCV monoinfection, and only 30-60% of HIV/HCV-coinfected individuals respond to HCV therapy with pegylated interferon and ribavirin. There are currently no biomarkers that predict treatment response in these coinfected patients.
We investigated whether there is an association between HCV treatment response and SNPs of apoptosis-related genes during HIV/HCV coinfection.
Genomic DNA from 53 HIV/HCV-coinfected individuals was analyzed for 82 SNPs of 10 apoptosis-related genes.
We found that the presence of the rs4242392 SNP in tumor necrosis factor receptor superfamily, member 10a (TNFRSF10A), which encodes for tumor necrosis factor-related apoptosis-inducing ligand receptor 1, predicts poor outcome to HCV therapy, in HIV/HCV-co-infected patients [odds ratio 5.91 (95% confidence interval 1.63-21.38, P = 0.007)].
The rs4242392 SNP of the tumor necrosis factor-related apoptosis-inducing ligand receptor 1 gene predicted poor interferon-based HCV treatment response in HIV/HCV-coinfected patients.

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Available from: Andrew D Badley, Mar 18, 2015
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    • "If TRAIL will finally act as a proviral or antiviral is mainly dependent on the overall cytokine situation and also on the type of virus [100]. It has been demonstrated that the SNP, rs4242392 of TRAIL gene is negatively associated with the interferon-based therapy outcome of HIV/HCV co-infected patients [101]. "
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