Long-term clinical evaluation of asymptomatic subjects positive for circulating Taenia solium antigens

Department of Community Health, Christian Medical College, Vellore, Tamil Nadu, India.
Transactions of the Royal Society of Tropical Medicine and Hygiene (Impact Factor: 1.84). 12/2010; 104(12):809-10. DOI: 10.1016/j.trstmh.2010.07.005
Source: PubMed


Although presence of cysticercal antigens in serum is presumed to indicate active cysticercosis not all positive persons are symptomatic. The significance of a positive antigen test in asymptomatic individuals, in predicting development of symptomatic cysticercosis on long-term follow up, is unknown. Forty two of 48 persons from Vellore district, India who were positive for circulating serum cysticercal antigens were followed up for four to five years. None of them developed clinical evidence of neurocysticercosis or subcutaneous cysts. We conclude that asymptomatic individuals with circulating cysticercal antigens have a low risk of developing symptomatic cysticercosis within four to five years.

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    • "Others have reported that monocytes exposed to helminth antigens have an impaired capability to differentiate into DCs 36-37. In addition, infection with metacestodes is accompanied by antigens in circulation 38-39 that might affect the activity of monocytes. To assess if the differentiation of monocytes into DCs was affected by TcES we added these antigens to our cultures at day 0 and 3. We found that there was no difference in the proportion of CD11c+ cells between cultures that received TcES during their differentiation and the ones that received it only as a final challenge, indicating that TcES did not affect the capability of human monocytes to differentiate into DCs (Fig 1B). "
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    ABSTRACT: Pathogens have developed strategies to modify Dendritic Cells (DCs) phenotypes and impair their functions in order to create a safer environment for their survival. DCs responses to helminths and their derivatives vary among different studies. Here we show that excretory/secretory products of the cestode Taenia crassiceps (TcES) do not induce the maturation of human DCs judged by a lack of increment in the expression of CD83, HLA-DR, CD80 and CD86 molecules but enhanced the production of IL-10 and positively modulated the expression of the C-type lectin receptor MGL and negatively modulated the expression of DC-SIGN. Additionally, these antigens were capable of down-modulating the inflammatory response induced by LPS in these cells by reducing the expression of the maturation markers and the production of the inflammatory cytokines IL-1β, TNF, IL-12 and IL-6. The effects of TcES upon the DCs responses to LPS were stronger if cells were exposed during their differentiation to the helminth antigens. All together, these findings suggest the ability of TcES to induce the differentiation of human DCs into a tolerogenic-like phenotype and to inhibit the effects of inflammatory stimuli.
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