GnRH-agonist induced depressive and anxiety symptoms during in vitro fertilization-embryo transfer cycles

Department of Psychiatry, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Fertility and sterility (Impact Factor: 4.59). 01/2011; 95(1):307-9. DOI: 10.1016/j.fertnstert.2010.07.1073
Source: PubMed


To determine whether the use of a GnRH agonist inducing a hypogonadic state during IVF-ET cycles induces negative mood symptoms, we conducted a prospective randomized study in 108 women comparing two different controlled ovarian stimulation protocols. A significant phase effect was observed for depression and anxiety symptoms during IVF-ET cycles reflecting an increase in symptoms between the hypogonadal phase and the peak in gonadotropin stimulation; however, the hypogonadal phase induced by the GnRH agonist was not associated with a significant increase in any of the studied mood parameters.

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Available from: Shaul - Schreiber, Oct 02, 2014
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    • "Thus, these findings may indicate that absolute 'extreme' GS levels may also be associated with mood symptoms . Recently, we reported the results of a study with a similar design but a much larger sample, which failed to show increased mood symptoms in the ''hypogonadal'' phase of the IVF protocol (Bloch et al., 2010). "
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    ABSTRACT: Purpose This study evaluated the changes in psychological stress during in vitro fertilization and embryo transfer (IVF–ET) and the relationship of such stress to the patients’ background and gender. Methods Sixty couples undergoing IVF–ET were administered the State–Trait Anxiety Inventory-JYZ (STAI) test at six different points during IVF–ET procedures. Anxiety scores at each time point were recorded and analyzed according to gender, fertility status, and duration of treatment. Results The median state anxiety score for women increased following induction until oocyte collection, after which it temporarily declined and then increased again until the pregnancy test. No such changes were noted in men. Scores for women who had undergone a shorter period of IVF treatments were higher while state and trait anxiety in men increased with a prolonged treatment period. Unsuccessful treatment increased the state and trait anxiety of women. Conclusions Psychological stress changed periodically depending on the duration of the patients’ treatment and fertility status also influenced anxiety levels. These findings will prove helpful in guiding psychological therapy and counseling for couples attempting to conceive by in vitro fertilization.
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