Immunotherapeutic approaches in prostate cancer: PROVENGE.

Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA.
Clinical advances in hematology & oncology: H&O 06/2010; 8(6):419-21.
Source: PubMed
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    • "When NK cells and T-cells infiltrate the prostate cancer microenvironment, they are exposed to potent immunosuppressive mechanisms that render them unable to kill tumour cells. Regulatory T-cells are frequently observed in prostate tumours with a CD4 + CD25 + FOXP3 + (FOXP3 is forkhead box P3) phenotype or a novel CD8 + FOXP3 + phenotype[9]; it is observed that these latter suppressive cells arise by the conversion of CD8 + effector cells when they enter the prostate tumour microenvironment[10]. Where cells are not converted into a suppressive phenotype, they can still be rendered anergic. "
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