Article

Backbone Dynamics of Cyclotide MCoTI‐I Free and Complexed with Trypsin

Department of Chemistry, State University of New York, Albany, NY 12222, USA.
Angewandte Chemie International Edition (Impact Factor: 11.26). 09/2010; 49(39):7030-4. DOI: 10.1002/anie.201002906
Source: PubMed

ABSTRACT

Showing some backbone: Most of the backbone NH groups of cyclotide MCoTI-I are constrained in the free state, which results in a well-folded compact structure, as indicated by {15N,1H} NMR spectroscopy (see picture). According to the backbone order parameter S2, the backbone mobility in trypsin-bound MCoTI-I is significantly increased.

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