Backbone Dynamics of Cyclotide MCoTI‐I Free and Complexed with Trypsin

Article (PDF Available)inAngewandte Chemie International Edition 49(39):7030-4 · September 2010with39 Reads
DOI: 10.1002/anie.201002906 · Source: PubMed
Abstract
Showing some backbone: Most of the backbone NH groups of cyclotide MCoTI-I are constrained in the free state, which results in a well-folded compact structure, as indicated by {15N,1H} NMR spectroscopy (see picture). According to the backbone order parameter S2, the backbone mobility in trypsin-bound MCoTI-I is significantly increased.