Measuring outcomes of importance to women with stress urinary incontinence

Health Economics Research Unit, University of Aberdeen, Aberdeen, UK.
BJOG An International Journal of Obstetrics & Gynaecology (Impact Factor: 3.45). 05/2009; 116(5). DOI: 10.1111/j.1471-0528.2008.02106.x
Source: OAI


Objective To provide evidence on outcomes of importance to women who have stress urinary incontinence (SUI). The secondary aim was to identify additional outcomes that ought to be collected in future primary studies or in systematic reviews of the literature.
Design Questionnaire survey of a cohort of women with SUI.
Setting UK.
Sample A total of 188 women with SUI.
Methods Areas of importance to women who suffer from SUI were assessed using a patient generated index (PGI). In addition to the PGI, the questionnaire included the King’s Health Questionnaire (KHQ) and the EuroQol-5D (EQ-5D).
Main outcome measures PGI, EQ-5D and the KHQ.
Results In total, 38 different areas were reported by respondents on the PGI. PGI and EQ-5D scores were positively correlated and significant. Correlations between the seven domains of the KHQ and PGI were all negative, but only two were statistically significant: personal relationships and severity measures.
Conclusions The PGI succeeded in capturing a diverse range of outcomes of importance to women suffering with SUI. Given the limited correlation between the KHQ domains and the PGI and, in addition, that the areas mentioned in the PGI were not found to map well to the EQ-5D, the PGI in this instance may be capturing concerns of women who suffer from SUI, which are not captured by quality-of-life measures such as the EQ-5D.

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    • "The correlations between EQ-5D and the individual ICS-QoL items were all in the expected direction but were not all statistically significant [8]. One study reported significant correlations in the expected direction for PGI and KHQ, but p-values were not specified [20]. Significant correlations were found with incontinence grade (p<0.05) "
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