Dibutyl Phthalate Contributes to the Thyroid Receptor Antagonistic Activity in Drinking Water Processes

State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, P.O. Box 2871 Beijing 100085, China.
Environmental Science & Technology (Impact Factor: 5.33). 09/2010; 44(17):6863-8. DOI: 10.1021/es101254c
Source: PubMed


It has long been recognized that thyroid hormone (TH) is essential for normal brain development in both humans and animals, and there is growing evidence that environmental chemicals can disrupt the thyroid system. In the present work, we used a two-hybrid yeast assay to screen for agonistic or antagonistic thyroid receptor (TR) mediated effects in drinking waters. We found no TR agonistic, but TR antagonistic activities in all samples from the drinking water processes. The TR antagonistic activities in organic extracts of water samples were then calibrated regarding to a known TR-inhibitor, NH3, and were expressed as the NH3 equivalents (TEQbio). The observed TEQbio in waters ranged from 180.8+/-24.8 to 280.2+/-48.2 microg/L NH3. To identify the specific compounds responsible for TR disrupting activities, the concentrations of potentially thyroid-disrupting chemicals including organochlorine pesticides (OCPs), phenols, and phthalates in organic extracts were quantitatively determined and their toxic equivalents with respect to NH3 (TEQcal) were estimated from their concentration-dependent relationships, respectively, using the same set of bioassays. Based on the TEQ approach, it was revealed that dibutyl phthalate (DBP) accounted for 53.7+/-8.2% to 105.5+/-16.7% of TEQbio. There was no effective removal of these potential thyroid disrupting substances throughout drinking water treatment processes.

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Available from: Zijian Wang, May 16, 2014
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    • "DBP traces in drinking and raw water were detected in our study and the highest concentration of DBP was observed at location A (0.210 μg/L) for drinking water and location F (0.353 μg/L) for raw water. Currently, there is not an effective way of removal or any treatment process for DBP persisting in drinking water samples (Li et al. 2010). "
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    • "Grade II surface water can be used to supply drinking water. It has been reported that the removal efficiency of PAE in drinking water treatment processes which include the activated carbon filtration was effective (Li et al., 2010). However, treatment of water in most drinking water treatment plants does not include use of activated carbon filtration and limited proportions of other EDCs could be removed (Luo et al., 2014; Padhye et al., 2014). "
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