Going Tubular in the Rostral Migratory Stream: Neurons Remodel Astrocyte Tubes to Promote Directional Migration in the Adult Brain

Neuroscience Center and the Department of Cell and Molecular Physiology, The University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
Neuron (Impact Factor: 15.05). 07/2010; 67(2):173-5. DOI: 10.1016/j.neuron.2010.07.013
Source: PubMed


Reciprocal interactions between migrating neurons and astroglia play influential roles in the guidance and placement of newly generated neurons in the cerebral cortex. During embryonic development, migrating neurons modulate the function of radial glial cells as neuronal migratory guides in the neocortex (Hatten, 1985 and Rakic, 2003). In contrast, in the adult brain, long distance neuronal migration is thought to occur in a glial-independent manner. In the rostral migratory stream (RMS), newly generated neurons from the subventricular zone migrate along each other as oriented chains toward their target locations in the olfactory bulb (Wichterle et al., 1997). During this process, neurons are encapsulated by a complex network of astrocyte tubes (Doetsch and Alvarez-Buylla, 1996 and Lois et al., 1996). The functional significance of these astroglial tubes, whether they merely act as barriers to prevent the dispersion of the young neuroblasts into the surrounding tissue or if they actively guide or orient the new neurons, has remained unclear.

Full-text preview

Available from:
  • Source
    • "However, neurogenesis is limited to the hippocampus and subventricular zone, and the RMS is one mechanism neurons use to relocate from these areas [50]. In the RMS, vascular cells and astroglia forming gap junctions are arranged parallel to the route of the migrating cells and provide scaffolding [51]. Cells in the RMS are believed to move by " chain migration " . "
    [Show abstract] [Hide abstract]
    ABSTRACT: Alzheimer's disease (AD) is a global health crisis with limited treatment options. Despite major advances in neurotherapeutics, poor brain penetration due to the blood-brain barrier continues to pose a big challenge in overcoming the access of therapeutics to the central nervous system. In that regard, the non-invasive intranasal route of brain targeting is gaining considerable attention. The nasal mucosa offers a large surface area, rapid absorption, and avoidance of first-pass metabolism increasing drug bioavailability with less systemic side effects. Intranasal delivery is known to utilize olfactory, rostral migratory stream, and trigeminal routes to reach the brain. This investigation confirmed that intranasal delivery of oligomeric amyloid-β antibody (NU4) utilized all three routes to enter the brain with a resident time of 96 hours post single bolus intranasal administration, and showed evidence of perikaryal and parenchymal uptake of NU4 in 5XFAD mouse brain, confirming the intranasal route as a non-invasive and efficient way of delivering therapeutics to the brain. In addition, this study demonstrated that intranasal delivery of NU4 antibody lowered cerebral amyloid-β and improved spatial learning in 5XFAD mice.
    Full-text · Article · Mar 2013 · Journal of Alzheimer's disease: JAD
  • Source
    • "Recently it has been found that migrating neuroblasts can modulate the structure of glial tube and have the ability to remove the impeding astrocytic processes away from their migrating route. This ability of neuroblasts may constantly modify the organization of the meshwork of the glial tube, helping efficient migration of neuroblast chains through the compact and narrow glial channels without creating choke points along the RMS (Eom et al., 2010; Kaneko et al., 2010). "
    [Show abstract] [Hide abstract]
    ABSTRACT: During the nervous system development, immature neuroblasts have a strong potential to migrate toward their destination. In the adult brain, new neurons are continuously generated in the neurogenic niche located near the ventricle, and the newly generated cells actively migrate toward their destination, olfactory bulb, via highly specialized migratory route called rostral migratory stream (RMS). Neuroblasts in the RMS form chains by their homophilic interactions, and the neuroblasts in chains continually migrate through the tunnels formed by meshwork of astrocytes, glial tube. This review focuses on the development and structure of RMS and the regulation of neuroblast migration in the RMS. Better understanding of RMS migration may be crucial for improving functional replacement therapy by supplying endogenous neuronal cells to the injury sites more efficiently.
    Full-text · Article · Dec 2010 · Anatomy & cell biology