Article

Pre- and Postnatal Health: Evidence of Increased Choline Needs

Cornell University, Division of Nutritional Sciences, 228 Savage Hall, Ithaca, NY, USA.
Journal of the American Dietetic Association (Impact Factor: 3.92). 08/2010; 110(8):1198-206. DOI: 10.1016/j.jada.2010.05.009
Source: PubMed

ABSTRACT

Choline, a micronutrient found in food, serves as the starting material for several important metabolites that play key roles in fetal development, particularly the brain. Although human beings' requirement for choline is unknown, an Adequate Intake level of 425 mg/day was established for women with upward adjustments to 450 and 550 mg/day during pregnancy and lactation, respectively. The importance of choline in human development is supported by observations that a human fetus receives a large supply of choline during gestation; pregnancy causes depletion of hepatic choline pools in rats consuming a normal diet; human neonates are born with blood levels that are three times higher than maternal blood concentrations; and large amounts of choline are present in human milk. The development of the central nervous system is particularly sensitive to choline availability with evidence of effects on neural tube closure and cognition. Existing data show that the majority of pregnant (and presumably lactating) women are not achieving the target intake levels and that certain common genetic variants may increase requirements for choline beyond current recommendations. Because choline is not found in most varieties of prenatal vitamins (or regular multivitamins), increased consumption of choline-rich foods may be needed to meet the high pre- and postnatal demands for choline.

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    • "The latter produce PC via a pathway that uses phosphatidylethanol-amine N-methyltransferase (PEMT) to convert PE to PC, while male mice make lesser use of this pathway to produce PC (Noga and Vance, 2003). The biological actions of PC include promotion of the synthesis of important neurotransmitters for memory and brain development (Caudill, 2010; Li and Vance, 2008). "
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    ABSTRACT: The composition of human milk has served as a basis for the development of infant formulas, which are used when breastfeeding is not possible. Among the human milk nutrients, 50% of the total energetic value corresponds to fat, with a high level of fatty acids and 0.2-2.0% present in the form of phospholipids (PLs). The PL contents and fatty acid distribution in PL species have been investigated as bioactive elements for the production of infant formulas, since they offer potential benefits for the optimum growth and health of the newborn infant. The differences in the amount of PLs and in fatty acid distribution in PL species between human milk and infant formulas can imply biologically significant differences for newborn infants fed with infant formulas versus human milk-mainly due to the greater proportion of sphingomyelin with respect to phosphatidylcholine in infant formulas. The limited information referred to the characterization of fatty acid distribution in PL species in infant formulas or in ingredients used to enrich them merits further research in order to obtain products with benefits similar to those of human milk in terms of infant growth, visual acuity and neurological development. The present review establishes the scientific basis for helping to adjust formulations to the requirements of infant nutrition.
    No preview · Article · Jun 2015 · Critical reviews in food science and nutrition
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    • "Long sleep (9+hrs) was also associated with reduced consumption of theobromine, a methylxanthine found in tea and chocolate and a metabolite of caffeine thought to have some stimulant effects but likely has no psychotropic effects in humans (Benton, 2004). It was also associated with choline, which is an essential micronutrient that is particularly important for fetal development (Caudill, 2010). "
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    • "B vitamins and methyl-group homeostasis have received considerable attention in recent years, providing a basis for understanding the complex interplay between nutrition and epigenetic modifications of disease-related genes, including those that are involved in aging and in Alzheimer's disease. For example, experimental modification of methyl-group homeostasis through dietary deficiency and supplementation of choline and folate has been shown to exert profound effects on brain development, function, and aging [10] [11] [12], including epigenetic modification and/or aberrant expression of key AD genes [13]. In light of this attention, it has been turned to the potential impact of food folic acid fortification and nutritional status in human metabolic programming [14] [15]. "
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    ABSTRACT: We are also grateful to Radwa Mohsen from Hindawi Publishing Corporation for the excellent assistance within the production of this issue.
    Full-text · Article · Jun 2012 · Current Gerontology and Geriatrics Research
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