... The 68 RCTs included a total of 4195 participants (ranging from 14 to 313 participants per RCT). The trials were conducted in high to upper-middle income economies: Australia (3 RCTs) [22,72,90], Brazil (7 RCTs) [23,25,26,47,48,74,77], Canada (2 RCTs) [64,67], China (8 RCTs) [53, 54, 68-71, 83, 88], France (1 RCT) [78], Germany (3 RCTs) [28,49,50], Italy (1 RCT) [45], Japan (1 RCT) [24], Malaysia (1 RCT) [37], Netherlands (1 RCT) [29], South Korea (4 RCTs) [65,66,76,86], Thailand (1 RCT) [59], Turkey (1 RCT) [31], United Kingdom (1 RCT) [32], and the United States (2 RCTs) [33,46]; and low to lower-middle income economies: Egypt (2 RCTs) [37,52], India (5 RCTs) [21,51,55,79,87], Iran (18 RCTs) [27, 29, 40, 42-44, 56-58, 62, 63, 72, 75, 81, 81, 83, 84, 89], Nigeria (2 RCTs) [59,91], and Pakistan (4 RCTs) [39,41,61,80]. The mean age of participants ranged from 20.4 to 74.3 years; nine RCTs with 524 participants total assessed older adults aged ≥ 60 years [24,33,45,48,54,72,76,89,90]. ...