Comparisons of Plasma/Serum Micronutrients Between Okinawan and Oregonian Elders: A Pilot Study

Department of Neurology, Oregon Health & Science University, Portland, OR 97239-3098, USA.
The Journals of Gerontology Series A Biological Sciences and Medical Sciences (Impact Factor: 5.42). 10/2010; 65(10):1060-7. DOI: 10.1093/gerona/glq124
Source: PubMed


Certain micronutrients are protective against cognitive decline. We examined whether there is any uniform pattern of circulating
micronutrients cross–culturally that are associated with successful cognitive aging. For the U.S. sample, we used the stored
serum/plasma of 115 participants, collected in Oregon, USA. The Okinawa sample consisted of 49 participants selected using
similar inclusion criteria as the Oregon sample, from the Keys to Optimal Cognitive Aging Project. All participants were aged
85 years and older without cognitive impairment. We found that the Okinawan elders used fewer vitamin supplements but had
similar levels of vitamin B12 and α-tocopherol, lower folate and γ-tocopherol, compared with Oregonian elders. That is, we did not find a uniform pattern
of circulating micronutrients, suggesting that micronutrients other than those examined here or other lifestyle factors than
nutrition could play an important role in achieving successful cognitive aging.

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    • "Recent genetics work has focused on genome-wide association studies and sequencing studies to explore specific areas of the genome implicated in human aging. Follow-up cohorts of older Okinawans have also been established for longitudinal study of particular age-related phenotypes, such as cognitive aging (Dodge et al., 2010; Katsumata et al., 2012). Intervention studies of the traditional Okinawan diet are also underway to assess biological effects on phenotypes reflective of healthy aging (Mano, Ishida, Ohya, Todoriki, & Takishita, 2009; Tuekpe, Todoriki, Sasaki, Zheng, & Ariizumi, 2006). "
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    ABSTRACT: In the second section, five chapters expose and clarify the known and hypoth-esized factors favoring healthy longevity, starting with genetic and environ-mental factors and comparing and contrasting populations in Okinawa and Hawaii (Chapter 7). Chapter 8 then underlines the importance of mobility in human aging, whereas Chapter 9 describes the physical and biological indi-cators of health for the oldest old in the United States. The final chapters in this section focus on genetics with an example of gene–gene interaction using Chinese data (Chapter 10) and an introduction to gene expression and longevity (Chapter 11).
    Full-text · Chapter · Nov 2013
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    • "Data came from the Keys to Optimal Cognitive Aging Project (KOCOA), a prospective pilot cohort study of community-dwelling older people aged 80 years and older living in Okinawa, Japan. A detailed description of the recruitment process has been presented elsewhere [20] [21]. Briefly, researchers visited 22 senior centers, explained the study protocol, and asked them to participate in the study. "
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    ABSTRACT: We cross-sectionally examined which lipid profiles are associated with better cognitive function among those aged 80 and older, free of dementia (Clinical Dementia Rating ≤0.5), functionally independent, and community-dwelling. Our cohort consisted of 193 participants from the "Keys to Optimal Cognitive Aging (KOCOA) Project", a prospective cohort study in Okinawa, Japan. Higher low-density lipoprotein cholesterol levels and lower triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratios were associated with higher scores in memory performance after controlling for confounders. Further research is required to clarify the associations among LDL-C levels, TG/HDL-C ratios, and healthy cognitive aging.
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    • "The Okinawan elders used fewer vitamin supplements but had similar levels of vitamin B12 and α-tocopherol, compared with Oregonian elders. Thus the components leading to healthy cognitive ageing might include a variety of patterns that include a healthy diet, high physical activity, and social engagement [22]. Additionally, cognitive function, daily activity, and residential status, have been reported to affect nutritional intake of centenarians [23,24]. "
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