Disseminated primary coccidioidomycosis of the chest wall

ArticleinThe Journal of thoracic and cardiovascular surgery 140(5):e78-9 · November 2010with6 Reads
DOI: 10.1016/j.jtcvs.2010.06.022 · Source: PubMed
  • [Show abstract] [Hide abstract] ABSTRACT: Summary Pulmonary zygomycosis is a relatively uncommon complication of solid organ or peripheral blood stem cell transplantation and has a high associated mortality. Optimal therapy consists of complete resection of infected tissue and treatment with amphotericin B (AmB). We describe two patients, one of whom underwent orthotopic heart transplantation and the other who received a peripheral blood stem cell transplant, who were diagnosed with invasive pulmonary zygomycosis. Both patients were treated with a liposomal preparation of AmB and early partial resection of the infected structures followed by prolonged posaconazole maintenance therapy. Despite incomplete resection, this treatment regimen resulted in a favourable outcome in both patients, including survival of more than 17 months in one patient at last follow up. For patients in whom complete resection of pulmonary zygomycosis is not possible, subtotal resection and treatment with liposomal AmB followed by therapy with posaconazole may be an effective treatment option.
    Full-text · Article · Feb 2009
  • Article · May 1995
  • [Show abstract] [Hide abstract] ABSTRACT: Coccidioidomycosis was first discovered by a medical student in Argentina in 1892, and knowledge about the infection mostly arose from observations of clinicians and scientists in California, primarily at Stanford University Medical Center. Some discoveries came by chance. Many others arose from careful epidemiologic and clinical investigations in the San Joaquin Valley during the 1930s, when people migrated there from the “Dust Bowl” of the Midwest, and during the 1940s, when the events of World War II brought military recruits, prisoners of war, and persons of Japanese descent to camps and other areas of endemicity. Especially impressive were the contributions of Charles E. Smith, who tirelessly studied this disease throughout his professional career.
    Article · Jun 2007
Show more