Are young injection drug users ready and willing to participate in preventive HCV vaccine trials?

San Mateo County Health Systems, San Mateo, CA, USA.
Vaccine (Impact Factor: 3.62). 08/2010; 28(37):5947-51. DOI: 10.1016/j.vaccine.2010.07.006
Source: PubMed


Trials to evaluate the efficacy of preventive HCV vaccines will need participation from high risk HCV seronegative injection drug users (IDUs). To guide trial planning, we assessed willingness of young IDU in San Francisco to participate in HCV vaccine efficacy trials and evaluate knowledge of vaccine trial concepts: placebo, randomization and blinding. During 2006 and 2007, a total of 67 participants completed the survey. A substantial proportion (88%) would definitely (44%) or probably (44%) be willing to participate in a randomized trial, but knowledge of vaccine trial concepts was low. Reported willingness to participate in an HCV vaccine trial decreased with increasing trial duration, with 67% of participants surveyed willing to participate in a trial of 1 year duration compared to 43% of participants willing to participate in a trial of 4 years duration. Willingness to enroll in HCV vaccine trials was higher in young IDU than reported by most at-risk populations in HIV vaccine trials. Educational strategies will be needed to ensure understanding of key concepts prior to implementing HCV vaccine trials.

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Available from: Ellen Stein, Aug 14, 2014
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    • "These barriers have been identified as prominent concerns among high-risk communities including PWID in HIV VPS (Buchbinder et al., 2004; Mills et al., 2004; Newman et al., 2007) and require further exploration. We also observed mistrust of biomedical research and concerns about being " used as a guinea pig " as observed previously among PWID (Levy et al., 2010; Treloar et al., 2010; Vlahov et al., 1994). It will be important to address such concerns by providing accurate, current and comprehensive information on candidate vaccines and trial design in plain language formats and by encouraging open dialogue prior to obtaining informed consent. "
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