Please cite this article in press as: Secchi F, et al. Optimizing dose and administration regimen of a high-relaxivity contrast agent for myocardial
MRI late gadolinium enhancement. Eur J Radiol (2010), doi:10.1016/j.ejrad.2010.06.040
ARTICLE IN PRESS
EURR-4860; No. of Pages 7
F. Secchi et al. / European Journal of Radiology xxx (2010) xxx–xxx 7
minor limitation of our study was the small number of patients who
resulted in a relatively large 95% CI of the maximum CNR between
infarcted myocardium and LV cavity.
In conclusion, our study demonstrate that, for myocardial
LGE at 1.5 T, a gadobenate dimeglumine dosage of 0.05 plus
0.05 mmol/kg separated by 10 min and imaging after other 10 min
produced a high contrast between infarcted myocardium and non-
infarcted myocardium and the highest contrast between infarcted
myocardium and LV cavity. For the combined differentiation of
infarcted myocardium vs the non-infarcted myocardium and vs the
LV cavity, this dosage and regimen of administration should be pre-
ferred to LGE imaging 10 min after injecting only 0.05 mmol/kg of
gadobenate, to LGE imaging 10 min after the unique administration
of 0.1 mmol/kg of gadobenate, and to LGE imaging 10 min after a
double injection of 0.1 mmol/kg plus 0.1 of gadobenate (separated
by 10 min). Finally, studies on LGE imaging at 15 or 20 min after
injection of 0.1 mmol/kg are warranted.
Conﬂicts of interest
Francesco Sardanelli is a consultant of Bracco Imaging SpA
This study was supported by Bracco Imaging SpA (Milan, Italy).
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